InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: ZFP36

Summary

InnateDB Gene

IDBG-50307.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ZFP36

Gene Name

zinc finger protein 36, C3H type, homolog (mouse)

Synonyms

G0S24; GOS24; NUP475; RNF162A; TIS11; TTP; zfp-36

Species

Homo sapiens

Ensembl Gene

ENSG00000128016

Encoded Proteins

IDBP-760690

IDBP-762594

IDBP-761481

IDBP-764642

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation from Orthologs

Summary

PMID 26019272

[Mus musculus] Dusp1 modulates the phosphorylation status of mRNA-destabilizing protein Zfp36 to regulate macrophage immune response to lipopolysaccharide.

Entrez Gene

Summary

Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.

Gene Information

Type

Protein coding

Genomic Location

Chromosome 19:39406813-39409412

Strand

Forward strand

Band

q13.2

Transcripts

ENST00000600033	ENSP00000470200
ENST00000594442	ENSP00000471239
ENST00000594045	ENSP00000472329
ENST00000597629	ENSP00000469647

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 52 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	52 [view]
Protein-Protein	48 [view]
Protein-DNA	2 [view]
Protein-RNA	2 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003727	single-stranded RNA binding
GO:0003729	mRNA binding
GO:0005515	protein binding
GO:0017091	AU-rich element binding
GO:0019901	protein kinase binding
GO:0019957	C-C chemokine binding
GO:0035925	mRNA 3'-UTR AU-rich region binding
GO:0044822	poly(A) RNA binding
GO:0046872	metal ion binding
GO:0071889	14-3-3 protein binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0000288	nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
GO:0000289	nuclear-transcribed mRNA poly(A) tail shortening
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0006402	mRNA catabolic process
GO:0010467	gene expression
GO:0016070	RNA metabolic process
GO:0016071	mRNA metabolic process
GO:0032680	regulation of tumor necrosis factor production
GO:0035278	negative regulation of translation involved in gene silencing by miRNA
GO:0035556	intracellular signal transduction
GO:0042594	response to starvation
GO:0043488	regulation of mRNA stability
GO:0045638	negative regulation of myeloid cell differentiation
GO:0050728	negative regulation of inflammatory response
GO:0050779	RNA destabilization
GO:0060213	positive regulation of nuclear-transcribed mRNA poly(A) tail shortening
GO:0070935	3'-UTR-mediated mRNA stabilization
GO:1900153	positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0010494	cytoplasmic stress granule

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000044786

View Gene Order

ENSBTAG00000008573

Not yet available

Pathways

NETPATH

REACTOME

REACT_25064

Tristetraprolin (TTP) destabilizes mRNA pathway

REACT_24994

Regulation of mRNA stability by proteins that bind AU-rich elements pathway

REACT_71

Gene Expression pathway

KEGG

INOH

PID NCI

erbb1_downstream_pathway

ErbB1 downstream signaling

Cross-References

SwissProt

TrEMBL

M0R252

UniProt Splice Variant

Entrez Gene

7538

UniGene

Hs.534052

RefSeq

NM_003407

HUGO

HGNC:12862

OMIM

190700

CCDS

CCDS12534

HPRD

01835

IMGT

EMBL

AC011500

GenPept

RNA Seq Atlas

7538