InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: ZFP36

Summary

InnateDB Gene

IDBG-637562.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ZFP36

Gene Name

tristetraprolin

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000008573

Encoded Proteins

IDBP-689579

tristetraproline

IDBP-689584

tristetraproline

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation from Orthologs

Summary

PMID 26019272

[Mus musculus] Dusp1 modulates the phosphorylation status of mRNA-destabilizing protein Zfp36 to regulate macrophage immune response to lipopolysaccharide.

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000128016:

Gene Information

Type

Protein coding

Genomic Location

Chromosome 18:49361494-49375317

Strand

Forward strand

Band

Transcripts

ENSBTAT00000011308	ENSBTAP00000054015
ENSBTAT00000066266	ENSBTAP00000055077

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 32 interaction(s) predicted by orthology.

Predicted by orthology
Total	32 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003729	mRNA binding
GO:0005515	protein binding
GO:0017091	AU-rich element binding
GO:0019901	protein kinase binding
GO:0019957	C-C chemokine binding
GO:0035925	mRNA 3'-UTR AU-rich region binding
GO:0044822	poly(A) RNA binding
GO:0046872	metal ion binding
GO:0071889	14-3-3 protein binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0000288	nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
GO:0000289	nuclear-transcribed mRNA poly(A) tail shortening
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0006402	mRNA catabolic process
GO:0032680	regulation of tumor necrosis factor production
GO:0035278	negative regulation of translation involved in gene silencing by miRNA
GO:0035556	intracellular signal transduction
GO:0042594	response to starvation
GO:0043488	regulation of mRNA stability
GO:0045638	negative regulation of myeloid cell differentiation
GO:0050728	negative regulation of inflammatory response
GO:0050779	RNA destabilization
GO:0060213	positive regulation of nuclear-transcribed mRNA poly(A) tail shortening
GO:0070935	3'-UTR-mediated mRNA stabilization
GO:1900153	positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0010494	cytoplasmic stress granule

Orthologs

Species

Homo sapiens

Mus musculus

Gene ID

Gene Order

ENSG00000128016

View Gene Order

ENSMUSG00000044786

View Gene Order

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

REACT_25064

Tristetraprolin (TTP) destabilizes mRNA pathway

REACT_24994

Regulation of mRNA stability by proteins that bind AU-rich elements pathway

REACT_71

Gene Expression pathway

REACT_198687

Regulation of mRNA stability by proteins that bind AU-rich elements pathway

REACT_198689

Tristetraprolin (TTP) destabilizes mRNA pathway

REACT_233572

Gene Expression pathway

KEGG

INOH

PID NCI

erbb1_downstream_pathway

ErbB1 downstream signaling

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Bt.3863

RefSeq

NM_174493

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

GenPept

RNA Seq Atlas