Homo sapiens Gene: ATP2B1 | |||||||||||||||||||||||
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Summary | |||||||||||||||||||||||
InnateDB Gene | IDBG-50612.6 | ||||||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||
Gene Symbol | ATP2B1 | ||||||||||||||||||||||
Gene Name | ATPase, Ca++ transporting, plasma membrane 1 | ||||||||||||||||||||||
Synonyms | PMCA1; PMCA1kb | ||||||||||||||||||||||
Species | Homo sapiens | ||||||||||||||||||||||
Ensembl Gene | ENSG00000070961 | ||||||||||||||||||||||
Encoded Proteins |
ATPase, Ca++ transporting, plasma membrane 1
ATPase, Ca++ transporting, plasma membrane 1
ATPase, Ca++ transporting, plasma membrane 1
ATPase, Ca++ transporting, plasma membrane 1
ATPase, Ca++ transporting, plasma membrane 1
ATPase, Ca++ transporting, plasma membrane 1
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Protein Structure | |||||||||||||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||||||
Entrez Gene | |||||||||||||||||||||||
Summary |
The protein encoded by this gene belongs to the family of P-type primary ion transport ATPases characterized by the formation of an aspartyl phosphate intermediate during the reaction cycle. These enzymes remove bivalent calcium ions from eukaryotic cells against very large concentration gradients and play a critical role in intracellular calcium homeostasis. The mammalian plasma membrane calcium ATPase isoforms are encoded by at least four separate genes and the diversity of these enzymes is further increased by alternative splicing of transcripts. The expression of different isoforms and splice variants is regulated in a developmental, tissue- and cell type-specific manner, suggesting that these pumps are functionally adapted to the physiological needs of particular cells and tissues. This gene encodes the plasma membrane calcium ATPase isoform 1. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008] |
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Gene Information | |||||||||||||||||||||||
Type | Protein coding | ||||||||||||||||||||||
Genomic Location | Chromosome 12:89588049-89709300 | ||||||||||||||||||||||
Strand | Reverse strand | ||||||||||||||||||||||
Band | q21.33 | ||||||||||||||||||||||
Transcripts | |||||||||||||||||||||||
Interactions | |||||||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||||||||||||||||
Species
Mus musculus
Bos taurus
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Gene ID
Gene Order
Not yet available
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Pathways | |||||||||||||||||||||||
NETPATH | |||||||||||||||||||||||
REACTOME |
Reduction of cytosolic Ca++ levels pathway
Platelet homeostasis pathway
Ion transport by P-type ATPases pathway
Transmembrane transport of small molecules pathway
Platelet calcium homeostasis pathway
Ion channel transport pathway
Hemostasis pathway
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KEGG |
Calcium signaling pathway pathway
Pancreatic secretion pathway
Salivary secretion pathway
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INOH | |||||||||||||||||||||||
PID NCI |
C-MYB transcription factor network
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Cross-References | |||||||||||||||||||||||
SwissProt | |||||||||||||||||||||||
TrEMBL | |||||||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||||||
Entrez Gene | |||||||||||||||||||||||
UniGene | Hs.506276 Hs.607220 Hs.610752 Hs.705540 | ||||||||||||||||||||||
RefSeq | NM_001001323 NM_001682 | ||||||||||||||||||||||
HUGO | |||||||||||||||||||||||
OMIM | |||||||||||||||||||||||
CCDS | CCDS41817 CCDS9035 | ||||||||||||||||||||||
HPRD | 00158 | ||||||||||||||||||||||
IMGT | |||||||||||||||||||||||
EMBL | |||||||||||||||||||||||
GenPept | |||||||||||||||||||||||
RNA Seq Atlas | |||||||||||||||||||||||