Homo sapiens Gene: CALM2
InnateDB Gene IDBG-50761.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CALM2
Gene Name calmodulin 2 (phosphorylase kinase, delta)
Species Homo sapiens
Ensembl Gene ENSG00000143933
Encoded Proteins
calmodulin 2 (phosphorylase kinase, delta)
calmodulin 2 (phosphorylase kinase, delta)
calmodulin 2 (phosphorylase kinase, delta)
calmodulin 2 (phosphorylase kinase, delta)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the EF-hand calcium-binding protein family. It is one of three genes which encode an identical calcium binding protein which is one of the four subunits of phosphorylase kinase. Two pseudogenes have been identified on chromosome 7 and X. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Oct 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:47160082-47176601
Strand Reverse strand
Band p21
ENST00000272298 ENSP00000272298
ENST00000409563 ENSP00000387065
ENST00000422269 ENSP00000476793
ENST00000432899 ENSP00000406112
ENST00000456319 ENSP00000411440
Number of Interactions This gene and/or its encoded proteins are associated with 81 experimentally validated interaction(s) in this database.
Experimentally validated
Total 81 [view]
Protein-Protein 81 [view]
Protein-DNA 0
Protein-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0016301 kinase activity
GO:0019904 protein domain specific binding
GO:0031432 titin binding
GO:0031996 thioesterase binding
GO:0031997 N-terminal myristoylation domain binding
GO:0043274 phospholipase binding
GO:0044325 ion channel binding
GO:0072542 protein phosphatase activator activity
Biological Process
GO:0002027 regulation of heart rate
GO:0002576 platelet degranulation
GO:0005513 detection of calcium ion
GO:0005975 carbohydrate metabolic process
GO:0005980 glycogen catabolic process
GO:0006006 glucose metabolic process
GO:0006936 muscle contraction
GO:0007165 signal transduction
GO:0007173 epidermal growth factor receptor signaling pathway
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007202 activation of phospholipase C activity
GO:0007268 synaptic transmission
GO:0007596 blood coagulation
GO:0007603 phototransduction, visible light
GO:0008543 fibroblast growth factor receptor signaling pathway
GO:0010880 regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
GO:0010881 regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
GO:0016056 rhodopsin mediated signaling pathway
GO:0016310 phosphorylation
GO:0021762 substantia nigra development
GO:0022400 regulation of rhodopsin mediated signaling pathway
GO:0030168 platelet activation
GO:0030801 positive regulation of cyclic nucleotide metabolic process
GO:0032465 regulation of cytokinesis
GO:0032516 positive regulation of phosphoprotein phosphatase activity
GO:0035307 positive regulation of protein dephosphorylation
GO:0038095 Fc-epsilon receptor signaling pathway
GO:0043647 inositol phosphate metabolic process
GO:0044281 small molecule metabolic process
GO:0045087 innate immune response
GO:0046209 nitric oxide metabolic process
GO:0048011 neurotrophin TRK receptor signaling pathway
GO:0050999 regulation of nitric-oxide synthase activity
GO:0051343 positive regulation of cyclic-nucleotide phosphodiesterase activity
GO:0051592 response to calcium ion
GO:0055117 regulation of cardiac muscle contraction
GO:0060315 negative regulation of ryanodine-sensitive calcium-release channel activity
GO:0060316 positive regulation of ryanodine-sensitive calcium-release channel activity
GO:0061024 membrane organization
GO:1901844 regulation of cell communication by electrical coupling involved in cardiac conduction
Cellular Component
GO:0000922 spindle pole
GO:0005576 extracellular region
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005813 centrosome
GO:0005829 cytosol
GO:0005876 spindle microtubule
GO:0005886 plasma membrane
GO:0030017 sarcomere
GO:0034704 calcium channel complex
GO:0070062 extracellular vesicular exosome
No orthologs found for this gene
Signaling by FGFR in disease pathway
Activation of CaMK IV pathway
CaM pathway pathway
Organelle biogenesis and maintenance pathway
Signalling by NGF pathway
Signaling by EGFR in Cancer pathway
Downstream signaling of activated FGFR pathway
Ca2+ pathway pathway
Phospholipase C-mediated cascade pathway
Myoclonic epilepsy of Lafora pathway
beta-catenin independent WNT signaling pathway
eNOS activation and regulation pathway
DAP12 signaling pathway
Signaling by Wnt pathway
Neuronal System pathway
Signaling by VEGF pathway
Signaling by EGFR pathway
Mitochondrial biogenesis pathway
Metabolism of carbohydrates pathway
Signaling by GPCR pathway
Innate Immune System pathway
PLC beta mediated events pathway
Metabolism of nitric oxide pathway
Ionotropic activity of Kainate Receptors pathway
Platelet degranulation pathway
Glycogen breakdown (glycogenolysis) pathway
Platelet activation, signaling and aggregation pathway
VEGFR2 mediated vascular permeability pathway
CaMK IV-mediated phosphorylation of CREB pathway
PLC-gamma1 signalling pathway
Fc epsilon receptor (FCERI) signaling pathway
Opioid Signalling pathway
Smooth Muscle Contraction pathway
DAG and IP3 signaling pathway
Signal Transduction pathway
Cam-PDE 1 activation pathway
Post NMDA receptor activation events pathway
Ras activation uopn Ca2+ infux through NMDA receptor pathway
G-protein mediated events pathway
Activation of Kainate Receptors upon glutamate binding pathway
Adaptive Immune System pathway
Diseases associated with visual transduction pathway
Immune System pathway
CREB phosphorylation through the activation of CaMKK pathway
Downstream signal transduction pathway
VEGFR2 mediated cell proliferation pathway
Activation of NMDA receptor upon glutamate binding and postsynaptic events pathway
CREB phosphorylation through the activation of Ras pathway
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers pathway
VEGFA-VEGFR2 Pathway pathway
Response to elevated platelet cytosolic Ca2+ pathway
Transcriptional activation of mitochondrial biogenesis pathway
NGF signalling via TRKA from the plasma membrane pathway
Translocation of GLUT4 to the plasma membrane pathway
Visual phototransduction pathway
Transmission across Chemical Synapses pathway
Activation of Ca-permeable Kainate Receptor pathway
Signaling by FGFR pathway
Muscle contraction pathway
Inositol phosphate metabolism pathway
The phototransduction cascade pathway
Signaling by PDGF pathway
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation pathway
Signaling by ERBB2 pathway
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell pathway
Metabolism pathway
Inactivation, recovery and regulation of the phototransduction cascade pathway
FCERI mediated Ca+2 mobilization pathway
DARPP-32 events pathway
Signaling by the B Cell Receptor (BCR) pathway
PLCG1 events in ERBB2 signaling pathway
Ca-dependent events pathway
Calmodulin induced events pathway
CREB phosphorylation through the activation of CaMKII pathway
Disease pathway
Glucose metabolism pathway
Glycogen storage diseases pathway
Hemostasis pathway
DAP12 interactions pathway
Membrane Trafficking pathway
Synthesis of IP3 and IP4 in the cytosol pathway
EGFR interacts with phospholipase C-gamma pathway
eNOS activation pathway
Calcium signaling pathway pathway
Phosphatidylinositol signaling system pathway
Oocyte meiosis pathway
Vascular smooth muscle contraction pathway
Long-term potentiation pathway
Neurotrophin signaling pathway pathway
Olfactory transduction pathway
Phototransduction pathway
Insulin signaling pathway pathway
GnRH signaling pathway pathway
Melanogenesis pathway
Salivary secretion pathway
Gastric acid secretion pathway
Alzheimer's disease pathway
Glioma pathway
UniProt Splice Variant
Entrez Gene
UniGene Hs.627866 Hs.718686
RefSeq NM_001743 NM_173649 NM_001163561
CCDS CCDS1832 CCDS1831 CCDS54356
HPRD 00242
RNA Seq Atlas