InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CALM2

Summary

InnateDB Protein

IDBP-50763.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CALM2

Protein Name

calmodulin 2 (phosphorylase kinase, delta)

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000272298

InnateDB Gene

IDBG-50761 (CALM2)

Protein Structure

UniProt Annotation

Function

Calmodulin mediates the control of a large number of enzymes, ion channels, aquaporins and other proteins by Ca(2+). Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases. Together with CCP110 and centrin, is involved in a genetic pathway that regulates the centrosome cycle and progression through cytokinesis. {ECO:0000269PubMed:16760425, ECO:0000269PubMed:23893133}.

Subcellular Localization

Cytoplasm, cytoskeleton, spindle {ECO:0000269PubMed:16760425}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000269PubMed:16760425}. Note=Distributed throughout the cell during interphase, but during mitosis becomes dramatically localized to the spindle poles and the spindle microtubules.

Disease Associations

Ventricular tachycardia, catecholaminergic polymorphic, 4 (CPVT4) [MIM:614916]: An arrhythmogenic disorder characterized by stress-induced, bidirectional ventricular tachycardia that may degenerate into cardiac arrest and cause sudden death. Patients present with recurrent syncope, seizures, or sudden death after physical activity or emotional stress. {ECO:0000269PubMed:23040497}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 81 experimentally validated interaction(s) in this database.

Experimentally validated
Total	81 [view]
Protein-Protein	81 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0016301	kinase activity
GO:0019904	protein domain specific binding
GO:0031432	titin binding
GO:0031996	thioesterase binding
GO:0031997	N-terminal myristoylation domain binding
GO:0043274	phospholipase binding
GO:0044325	ion channel binding
GO:0072542	protein phosphatase activator activity

Biological Process

GO:0002027	regulation of heart rate
GO:0002576	platelet degranulation
GO:0005513	detection of calcium ion
GO:0005975	carbohydrate metabolic process
GO:0005980	glycogen catabolic process
GO:0006006	glucose metabolic process
GO:0006936	muscle contraction
GO:0007165	signal transduction
GO:0007173	epidermal growth factor receptor signaling pathway
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007202	activation of phospholipase C activity
GO:0007268	synaptic transmission
GO:0007596	blood coagulation
GO:0007603	phototransduction, visible light
GO:0008543	fibroblast growth factor receptor signaling pathway
GO:0010880	regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
GO:0010881	regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
GO:0016056	rhodopsin mediated signaling pathway
GO:0016310	phosphorylation
GO:0021762	substantia nigra development
GO:0022400	regulation of rhodopsin mediated signaling pathway
GO:0030168	platelet activation
GO:0030801	positive regulation of cyclic nucleotide metabolic process
GO:0032465	regulation of cytokinesis
GO:0032516	positive regulation of phosphoprotein phosphatase activity
GO:0035307	positive regulation of protein dephosphorylation
GO:0038095	Fc-epsilon receptor signaling pathway
GO:0043647	inositol phosphate metabolic process
GO:0044281	small molecule metabolic process
GO:0045087	innate immune response
GO:0046209	nitric oxide metabolic process
GO:0048011	neurotrophin TRK receptor signaling pathway
GO:0050999	regulation of nitric-oxide synthase activity
GO:0051343	positive regulation of cyclic-nucleotide phosphodiesterase activity
GO:0051592	response to calcium ion
GO:0055117	regulation of cardiac muscle contraction
GO:0060315	negative regulation of ryanodine-sensitive calcium-release channel activity
GO:0060316	positive regulation of ryanodine-sensitive calcium-release channel activity
GO:0061024	membrane organization
GO:1901844	regulation of cell communication by electrical coupling involved in cardiac conduction

Cellular Component

GO:0000922	spindle pole
GO:0005576	extracellular region
GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005737	cytoplasm
GO:0005813	centrosome
GO:0005829	cytosol
GO:0005876	spindle microtubule
GO:0005886	plasma membrane
GO:0030017	sarcomere
GO:0034704	calcium channel complex
GO:0070062	extracellular vesicular exosome