Version 5.4
Homo sapiens Gene: DYRK1B
Summary
InnateDB Gene IDBG-50782.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DYRK1B
Gene Name dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B
Synonyms AOMS3; MIRK
Species Homo sapiens
Ensembl Gene ENSG00000105204
Encoded Proteins
IDBP-50784
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B
IDBP-50786
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B
IDBP-379960
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B
IDBP-765247
IDBP-765712
IDBP-762883
IDBP-760909
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary DYRK1B is a member of the DYRK family of protein kinases. DYRK1B contains a bipartite nuclear localization signal and is found mainly in muscle and testis. The protein is proposed to be involved in the regulation of nuclear functions. Three isoforms of DYRK1B have been identified differing in the presence of two alternatively spliced exons within the catalytic domain. [provided by RefSeq, Jul 2008]
This gene encodes a member of a family of nuclear-localized protein kinases. The encoded protein participates in the regulation of the cell cycle. Expression of this gene may be altered in tumor cells, and mutations in this gene were found to cause abdominal obesity-metabolic syndrome 3. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2014]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:39825350-39834201
Strand Reverse strand
Band q13.2
Transcripts
ENST00000323039 ENSP00000312789
ENST00000348817 ENSP00000221803
ENST00000430012 ENSP00000403182
ENST00000601972 ENSP00000472861
ENST00000600611 ENSP00000471609
ENST00000597639 ENSP00000472941
ENST00000601696
ENST00000593685 ENSP00000469863
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 71 experimentally validated interaction(s) in this database.
Experimentally validated
Total 71 [view]
Protein-Protein 70 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003713 transcription coactivator activity
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004712 protein serine/threonine/tyrosine kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
Biological Process
GO:0006468 protein phosphorylation
GO:0007520 myoblast fusion
GO:0008152 metabolic process
GO:0018108 peptidyl-tyrosine phosphorylation
GO:0045893 positive regulation of transcription, DNA-templated
Cellular Component
GO:0005634 nucleus
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000002409
View Gene Order
ENSBTAG00000012509
Not yet available
Pathways
NETPATH
NetPath_4
EGFR1 pathway
NetPath_11
TCR pathway
REACTOME
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.130988
RefSeq NM_004714 NM_006483 NM_006484 XM_005259395 XM_005259398 XM_006723464 XM_006723465
HUGO
OMIM
CCDS CCDS12543 CCDS12544 CCDS46075
HPRD 05188
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca