InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: DYRK1B

Summary

InnateDB Protein

IDBP-50784.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

DYRK1B

Protein Name

dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B

Synonyms

AOMS3; MIRK;

Species

Homo sapiens

Ensembl Protein

ENSP00000312789

InnateDB Gene

IDBG-50782 (DYRK1B)

Protein Structure

UniProt Annotation

Function

Dual-specificity kinase which possesses both serine/ threonine and tyrosine kinase activities. Enhances the transcriptional activity of TCF1/HNF1A and FOXO1. Inhibits epithelial cell migration. Mediates colon carcinoma cell survival in mitogen-poor environments. {ECO:0000269PubMed:10910078, ECO:0000269PubMed:11980910, ECO:0000269PubMed:14500717}.

Subcellular Localization

Nucleus.

Disease Associations

Tissue Specificity

Highest expression in skeletal muscle, testis, heart and brain with little expression in colon or lung. Expressed in a variety of tumor cell lines. {ECO:0000269PubMed:10910078}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 71 experimentally validated interaction(s) in this database.

Experimentally validated
Total	71 [view]
Protein-Protein	70 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003713	transcription coactivator activity
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004712	protein serine/threonine/tyrosine kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups

Biological Process

GO:0006468	protein phosphorylation
GO:0018108	peptidyl-tyrosine phosphorylation
GO:0045893	positive regulation of transcription, DNA-templated

Cellular Component

GO:0005634

nucleus

Protein Structure and Domains

PDB ID

InterPro

IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002290 Serine/threonine/dual specificity protein kinase, catalytic domain
IPR011009 Protein kinase-like domain
IPR020635 Tyrosine-protein kinase, catalytic domain

PFAM

PF00069
PF07714

PRINTS

PR00109

PIRSF

SMART

SM00220
SM00219

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt