|Homo sapiens Gene: PTRF|
|Last Modified||2014-10-13 [Report errors or provide feedback]|
|Gene Name||polymerase I and transcript release factor|
polymerase I and transcript release factor
|Useful resources||Stemformatics EHFPI ImmGen|
This gene encodes a protein that enables the dissociation of paused ternary polymerase I transcription complexes from the 3' end of pre-rRNA transcripts. This protein regulates rRNA transcription by promoting the dissociation of transcription complexes and the reinitiation of polymerase I on nascent rRNA transcripts. This protein also localizes to caveolae at the plasma membrane and is thought to play a critical role in the formation of caveolae and the stabilization of caveolins. This protein translocates from caveolae to the cytoplasm after insulin stimulation. Caveolae contain truncated forms of this protein and may be the site of phosphorylation-dependent proteolysis. This protein is also thought to modify lipid metabolism and insulin-regulated gene expression. Mutations in this gene result in a disorder characterized by generalized lipodystrophy and muscular dystrophy. [provided by RefSeq, Nov 2009]
|Genomic Location||Chromosome 17:42402452-42423517|
|Number of Interactions||
This gene and/or its encoded proteins are associated with 44 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.
RNA Polymerase I Transcription pathway
RNA Polymerase I Transcription Termination pathway
RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription pathway
Gene Expression pathway
|UniProt Splice Variant|
|RNA Seq Atlas|