InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: DCN

Summary

InnateDB Gene

IDBG-50872.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

DCN

Gene Name

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Synonyms

CSCD; DSPG2; PG40; PGII; PGS2; SLRR1B

Species

Homo sapiens

Ensembl Gene

ENSG00000011465

Encoded Proteins

IDBP-50874

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IDBP-244191

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IDBP-381071

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IDBP-381072

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IDBP-381074

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IDBP-381075

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IDBP-601806

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IDBP-585781

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IDBP-599721

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IDBP-594928

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IDBP-584342

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IDBP-594495

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IDBP-588626

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IDBP-592960

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IDBP-601542

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IDBP-601600

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IDBP-586322

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IDBP-596800

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IDBP-603643

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Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 22087031

DCN (Decorin) is an extracellular matrix proteoglycan that stimulates proinflammatory PDCD4 and decreases the abundance of MIR21, boosting inflammatory activity in sepsis and suppressing tumour growth.

InnateDB Annotation from Orthologs

Summary

PMID 22087031

[Mus musculus] Dcn (Decorin) is an extracellular matrix proteoglycan that stimulates proinflammatory Pdcd4 and decreases the abundance of mmu-mir-21, boosting inflammatory activity in sepsis and suppressing tumour growth.

Entrez Gene

Summary

The protein encoded by this gene is a small cellular or pericellular matrix proteoglycan that is closely related in structure to biglycan protein. The encoded protein and biglycan are thought to be the result of a gene duplication. This protein is a component of connective tissue, binds to type I collagen fibrils, and plays a role in matrix assembly. It contains one attached glycosaminoglycan chain. This protein is capable of suppressing the growth of various tumor cell lines. There are multiple alternatively spliced transcript variants known for this gene. This gene is a candidate gene for Marfan syndrome. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 12:91140484-91183123

Strand

Reverse strand

Band

q21.33

Transcripts

ENST00000052754	ENSP00000052754
ENST00000393155	ENSP00000376862
ENST00000420120	ENSP00000413723
ENST00000425043	ENSP00000401021
ENST00000441303	ENSP00000399815
ENST00000456569	ENSP00000398514
ENST00000548218	ENSP00000448853
ENST00000552962	ENSP00000447654
ENST00000547568	ENSP00000447674
ENST00000546391	ENSP00000446530
ENST00000550758	ENSP00000449408
ENST00000547937	ENSP00000449782
ENST00000552145	ENSP00000447886
ENST00000550563	ENSP00000449014
ENST00000549513	ENSP00000449438
ENST00000546370	ENSP00000446527
ENST00000546745	ENSP00000448857
ENST00000550099	ENSP00000448057
ENST00000551354	ENSP00000448274
ENST00000548768

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 25 experimentally validated interaction(s) in this database.

Experimentally validated
Total	25 [view]
Protein-Protein	24 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0005518	collagen binding
GO:0005539	glycosaminoglycan binding
GO:0044822	poly(A) RNA binding
GO:0047485	protein N-terminus binding
GO:0050840	extracellular matrix binding

Biological Process

GO:0001822	kidney development
GO:0001890	placenta development
GO:0005975	carbohydrate metabolic process
GO:0007519	skeletal muscle tissue development
GO:0007568	aging
GO:0009612	response to mechanical stimulus
GO:0009887	organ morphogenesis
GO:0019800	peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan
GO:0022617	extracellular matrix disassembly
GO:0030198	extracellular matrix organization
GO:0030203	glycosaminoglycan metabolic process
GO:0030204	chondroitin sulfate metabolic process
GO:0030206	chondroitin sulfate biosynthetic process
GO:0030207	chondroitin sulfate catabolic process
GO:0030208	dermatan sulfate biosynthetic process
GO:0032496	response to lipopolysaccharide
GO:0042060	wound healing
GO:0044281	small molecule metabolic process
GO:0045087	innate immune response (InnateDB)

Cellular Component

GO:0005576	extracellular region
GO:0005578	proteinaceous extracellular matrix
GO:0005589	collagen type VI trimer
GO:0005615	extracellular space
GO:0005796	Golgi lumen
GO:0031012	extracellular matrix
GO:0043202	lysosomal lumen