Version 5.4
Homo sapiens Gene: PTPRN2
Summary
InnateDB Gene IDBG-50943.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PTPRN2
Gene Name protein tyrosine phosphatase, receptor type, N polypeptide 2
Synonyms IA-2beta; IAR; ICAAR; PTPRP; R-PTP-N2
Species Homo sapiens
Ensembl Gene ENSG00000155093
Encoded Proteins
IDBP-50947
protein tyrosine phosphatase, receptor type, N polypeptide 2
IDBP-50951
protein tyrosine phosphatase, receptor type, N polypeptide 2
IDBP-50955
protein tyrosine phosphatase, receptor type, N polypeptide 2
IDBP-293605
protein tyrosine phosphatase, receptor type, N polypeptide 2
IDBP-293621
protein tyrosine phosphatase, receptor type, N polypeptide 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and a single intracellular catalytic domain, and thus represents a receptor-type PTP. The catalytic domain of this PTP is most closely related to PTPRN/IA-2beta. This PTP and PTPRN are both found to be major autoantigens associated with insulin-dependent diabetes mellitus. Three alternatively spliced transcript variants of this gene, which encode distinct proteins, have been reported. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:157539056-158587788
Strand Reverse strand
Band q36.3
Transcripts
ENST00000389418 ENSP00000374069
ENST00000389416 ENSP00000374067
ENST00000389413 ENSP00000374064
ENST00000409483 ENSP00000387114
ENST00000404321 ENSP00000385464
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
Experimentally validated
Total 7 [view]
Protein-Protein 5 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004725 protein tyrosine phosphatase activity
GO:0005001 transmembrane receptor protein tyrosine phosphatase activity
GO:0005515 protein binding
GO:0016791 phosphatase activity
Biological Process
GO:0006470 protein dephosphorylation
GO:0016311 dephosphorylation
GO:0034260 negative regulation of GTPase activity
GO:0035335 peptidyl-tyrosine dephosphorylation
Cellular Component
GO:0005737 cytoplasm
GO:0005788 endoplasmic reticulum lumen
GO:0005887 integral component of plasma membrane
GO:0030141 secretory granule
GO:0030658 transport vesicle membrane
GO:0043195 terminal bouton
GO:0043235 receptor complex
Orthologs
Species
Mus musculus
Gene ID
Gene Order
ENSMUSG00000056553
View Gene Order
Pathways
NETPATH
REACTOME
KEGG
hsa04940
Type I diabetes mellitus pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL E7EM83 Q9NSR5
UniProt Splice Variant
Entrez Gene 5799
UniGene Hs.490789 Hs.642479
RefSeq NM_002847 NM_130842 NM_130843
HUGO HGNC:9677
OMIM 601698
CCDS CCDS5947 CCDS5948 CCDS5949
HPRD 03413
IMGT
EMBL AC005481 AC006003 AC006372 AC011899 AC019043 AC078942 AC093662 AC093856 AC125243 AL157451
GenPept CAB75665
RNA Seq Atlas 5799

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca