InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PTPRN2

Summary

InnateDB Protein

IDBP-50947.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PTPRN2

Protein Name

protein tyrosine phosphatase, receptor type, N polypeptide 2

Synonyms

IA-2beta; IAR; ICAAR; PTPRP; R-PTP-N2;

Species

Homo sapiens

Ensembl Protein

ENSP00000374069

InnateDB Gene

IDBG-50943 (PTPRN2)

Protein Structure

UniProt Annotation

Function

Implicated in development of nervous system and pancreatic endocrine cells. {ECO:0000269PubMed:8798755, ECO:0000269PubMed:8878534}.

Subcellular Localization

Cytoplasmic vesicle, secretory vesicle membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.

Disease Associations

Tissue Specificity

Highest levels in brain and pancreas. Lower levels in trachea, prostate, stomach and spinal chord.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.

Experimentally validated
Total	7 [view]
Protein-Protein	5 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004725	protein tyrosine phosphatase activity
GO:0005001	transmembrane receptor protein tyrosine phosphatase activity
GO:0005515	protein binding
GO:0016791	phosphatase activity

Biological Process

GO:0006470	protein dephosphorylation
GO:0016311	dephosphorylation
GO:0034260	negative regulation of GTPase activity
GO:0035335	peptidyl-tyrosine dephosphorylation

Cellular Component

GO:0005737	cytoplasm
GO:0005788	endoplasmic reticulum lumen
GO:0005887	integral component of plasma membrane
GO:0030141	secretory granule
GO:0030658	transport vesicle membrane
GO:0043195	terminal bouton
GO:0043235	receptor complex

Protein Structure and Domains

PDB ID

InterPro

IPR000242 Protein-tyrosine phosphatase, receptor/non-receptor type
IPR000387 Protein-tyrosine/Dual specificity phosphatase
IPR003595 Protein-tyrosine phosphatase, catalytic
IPR021613 Protein-tyrosine phosphatase receptor IA-2 ectodomain
IPR029021 Protein-tyrosine phosphatase-like

PFAM

PF00102
PF11548

PRINTS

PR00700

PIRSF

SMART

SM00194
SM00404

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt