Version 5.4
Homo sapiens Gene: TUT1
Summary
InnateDB Gene IDBG-51191.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TUT1
Gene Name terminal uridylyl transferase 1, U6 snRNA-specific
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000149016
Encoded Proteins
IDBP-51193
terminal uridylyl transferase 1, U6 snRNA-specific
IDBP-51195
terminal uridylyl transferase 1, U6 snRNA-specific
IDBP-485555
terminal uridylyl transferase 1, U6 snRNA-specific
IDBP-485557
terminal uridylyl transferase 1, U6 snRNA-specific
IDBP-485558
terminal uridylyl transferase 1, U6 snRNA-specific
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a nucleotidyl transferase that functions as both a terminal uridylyltransferase and a nuclear poly(A) polymerase. The encoded enzyme specifically adds and removes nucleotides from the 3' end of small nuclear RNAs and select mRNAs and may function in controlling gene expression and cell proliferation.[provided by RefSeq, Apr 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:62575045-62592177
Strand Reverse strand
Band q12.3
Transcripts
ENST00000308436 ENSP00000308000
ENST00000278279 ENSP00000278279
ENST00000476907 ENSP00000419607
ENST00000463241
ENST00000469480
ENST00000494385 ENSP00000420739
ENST00000478537 ENSP00000419792
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 30 experimentally validated interaction(s) in this database.
Experimentally validated
Total 30 [view]
Protein-Protein 29 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0003676 nucleic acid binding
GO:0003723 RNA binding
GO:0003730 mRNA 3'-UTR binding
GO:0004652 polynucleotide adenylyltransferase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0019899 enzyme binding
GO:0046872 metal ion binding
GO:0050265 RNA uridylyltransferase activity
Biological Process
GO:0006378 mRNA polyadenylation
GO:0006379 mRNA cleavage
GO:0016180 snRNA processing
Cellular Component
GO:0005634 nucleus
GO:0005730 nucleolus
GO:0005847 mRNA cleavage and polyadenylation specificity factor complex
GO:0016607 nuclear speck
GO:0045171 intercellular bridge
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
ENSMUSG00000071645
View Gene Order
Ortholuge
SSD Ortholog
Ortholog supports species divergence
ENSBTAG00000011846
Not yet available
Ortholuge
SSD Ortholog
Ortholog supports species divergence
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.656532 Hs.728983
RefSeq NM_022830
HUGO
OMIM
CCDS CCDS8021
HPRD 15226
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca