Homo sapiens Gene: MAP3K10
Summary
InnateDB Gene IDBG-51212.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MAP3K10
Gene Name mitogen-activated protein kinase kinase kinase 10
Synonyms MEKK10; MLK2; MST;
Species Homo sapiens
Ensembl Gene ENSG00000130758
Encoded Proteins
mitogen-activated protein kinase kinase kinase 10
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a member of the serine/threonine kinase family. This kinase has been shown to activate MAPK8/JNK and MKK4/SEK1, and this kinase itself can be phoshorylated, and thus activated by JNK kinases. This kinase functions preferentially on the JNK signaling pathway, and is reported to be involved in nerve growth factor (NGF) induced neuronal apoptosis. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:40191744-40215575
Strand Forward strand
Band q13.2
Transcripts
ENST00000253055 ENSP00000253055
ENST00000597986 ENSP00000471916
ENST00000593502 ENSP00000473021
ENST00000594951 ENSP00000471116
ENST00000601702
ENST00000594569
ENST00000594791
ENST00000593906
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 33 experimentally validated interaction(s) in this database.
Experimentally validated
Total 33 [view]
Protein-Protein 33 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003714 transcription corepressor activity
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004706 JUN kinase kinase kinase activity
GO:0004709 MAP kinase kinase kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0042803 protein homodimerization activity
GO:0043425 bHLH transcription factor binding
Biological Process
GO:0000165 MAPK cascade
GO:0000186 activation of MAPKK activity
GO:0006468 protein phosphorylation
GO:0006915 apoptotic process
GO:0007165 signal transduction
GO:0007224 smoothened signaling pathway
GO:0007254 JNK cascade
GO:0007256 activation of JNKK activity
GO:0007257 activation of JUN kinase activity
GO:0008219 cell death
GO:0018105 peptidyl-serine phosphorylation
GO:0018107 peptidyl-threonine phosphorylation
GO:0043065 positive regulation of apoptotic process
GO:0043433 negative regulation of sequence-specific DNA binding transcription factor activity
GO:0043507 positive regulation of JUN kinase activity
GO:0045892 negative regulation of transcription, DNA-templated
GO:0046330 positive regulation of JNK cascade
GO:0046777 protein autophosphorylation
Cellular Component
GO:0005737 cytoplasm
Orthologs
Species
Mus musculus
Gene ID
Gene Order
Method
Confidence
Comments
Low
Tentative data, uncurated. RBBH derived.
Pathways
NETPATH
REACTOME
KEGG
INOH
IL-7 signaling pathway
JAK STAT pathway and regulation pathway
EPO signaling pathway pathway
VEGF signaling pathway pathway
PID BIOCARTA
PID NCI
p38 MAPK signaling pathway
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.466743
RefSeq NM_002446 XM_006723222 XM_006723223
HUGO
OMIM
CCDS CCDS12549
HPRD 02533
IMGT
EMBL
GenPept
RNA Seq Atlas