Homo sapiens Gene: AKT2
Summary
InnateDB Gene IDBG-51270.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol AKT2
Gene Name v-akt murine thymoma viral oncogene homolog 2
Synonyms HIHGHH; PKBB; PKBBETA; PRKBB; RAC-BETA;
Species Homo sapiens
Ensembl Gene ENSG00000105221
Encoded Proteins
v-akt murine thymoma viral oncogene homolog 2
v-akt murine thymoma viral oncogene homolog 2
v-akt murine thymoma viral oncogene homolog 2
v-akt murine thymoma viral oncogene homolog 2
v-akt murine thymoma viral oncogene homolog 2
v-akt murine thymoma viral oncogene homolog 2
v-akt murine thymoma viral oncogene homolog 2
v-akt murine thymoma viral oncogene homolog 2
v-akt murine thymoma viral oncogene homolog 2
v-akt murine thymoma viral oncogene homolog 2
v-akt murine thymoma viral oncogene homolog 2
v-akt murine thymoma viral oncogene homolog 2
v-akt murine thymoma viral oncogene homolog 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene is a putative oncogene encoding a protein belonging to a subfamily of serine/threonine kinases containing SH2-like (Src homology 2-like) domains. The gene was shown to be amplified and overexpressed in 2 of 8 ovarian carcinoma cell lines and 2 of 15 primary ovarian tumors. Overexpression contributes to the malignant phenotype of a subset of human ductal pancreatic cancers. The encoded protein is a general protein kinase capable of phophorylating several known proteins. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:40230317-40285536
Strand Reverse strand
Band q13.2
Transcripts
ENST00000358335 ENSP00000351095
ENST00000311278 ENSP00000309428
ENST00000392038 ENSP00000375892
ENST00000392037 ENSP00000375891
ENST00000391845
ENST00000391844 ENSP00000375719
ENST00000424901 ENSP00000399532
ENST00000452077 ENSP00000404083
ENST00000416362 ENSP00000407999
ENST00000423127 ENSP00000403842
ENST00000456441 ENSP00000396532
ENST00000416994 ENSP00000392458
ENST00000427375 ENSP00000403890
ENST00000441941 ENSP00000396968
ENST00000486368 ENSP00000463686
ENST00000483166
ENST00000476266
ENST00000489375 ENSP00000470822
ENST00000496089
ENST00000497948 ENSP00000472382
ENST00000476247 ENSP00000463368
ENST00000480878
ENST00000486647
ENST00000491778 ENSP00000463086
ENST00000492463 ENSP00000462776
ENST00000487537
ENST00000498350
ENST00000537834
ENST00000581582
ENST00000584288 ENSP00000462469
ENST00000580878
ENST00000579047 ENSP00000471369
ENST00000601166 ENSP00000472371
ENST00000578975
ENST00000578282
ENST00000583859 ENSP00000462715
ENST00000578615 ENSP00000463262
ENST00000580747 ENSP00000463806
ENST00000578310 ENSP00000462919
ENST00000596634 ENSP00000470604
ENST00000579345
ENST00000578123 ENSP00000462022
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 75 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.
Experimentally validated
Total 75 [view]
Protein-Protein 74 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 9 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016301 kinase activity
GO:0016772 transferase activity, transferring phosphorus-containing groups
Biological Process
GO:0001934 positive regulation of protein phosphorylation
GO:0005978 glycogen biosynthetic process
GO:0006006 glucose metabolic process
GO:0006417 regulation of translation
GO:0006464 cellular protein modification process
GO:0006468 protein phosphorylation
GO:0006915 apoptotic process
GO:0007165 signal transduction
GO:0008286 insulin receptor signaling pathway
GO:0008643 carbohydrate transport
GO:0010748 negative regulation of plasma membrane long-chain fatty acid transport
GO:0010907 positive regulation of glucose metabolic process
GO:0030334 regulation of cell migration
GO:0031340 positive regulation of vesicle fusion
GO:0032000 positive regulation of fatty acid beta-oxidation
GO:0032287 peripheral nervous system myelin maintenance
GO:0032859 activation of Ral GTPase activity
GO:0032869 cellular response to insulin stimulus
GO:0045444 fat cell differentiation
GO:0045725 positive regulation of glycogen biosynthetic process
GO:0046326 positive regulation of glucose import
GO:0060644 mammary gland epithelial cell differentiation
GO:0061024 membrane organization
GO:0065002 intracellular protein transmembrane transport
GO:0071156 regulation of cell cycle arrest
GO:0072659 protein localization to plasma membrane
GO:0090314 positive regulation of protein targeting to membrane
GO:2000147 positive regulation of cell motility
GO:2001275 positive regulation of glucose import in response to insulin stimulus
Cellular Component
GO:0005634 nucleus
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005938 cell cortex
GO:0032587 ruffle membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
TNFalpha pathway
RANKL pathway
FSH pathway
TWEAK pathway
REACTOME
AKT-mediated inactivation of FOXO1A pathway
Signaling by FGFR in disease pathway
Developmental Biology pathway
Signalling by NGF pathway
Signaling by EGFR in Cancer pathway
PI3K/AKT activation pathway
Downstream signaling of activated FGFR pathway
PKB-mediated events pathway
misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling pathway
Signaling by WNT in cancer pathway
PI-3K cascade pathway
PI3K events in ERBB2 signaling pathway
DAP12 signaling pathway
mTOR signalling pathway
Signaling by Wnt pathway
Inhibition of TSC complex formation by PKB pathway
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) pathway
Signaling by VEGF pathway
Signaling by EGFR pathway
Role of LAT2/NTAL/LAB on calcium mobilization pathway
Constitutive PI3K/AKT Signaling in Cancer pathway
Signaling by GPCR pathway
Downregulation of ERBB2:ERBB3 signaling pathway
Innate Immune System pathway
Signaling by ERBB4 pathway
Regulation of beta-cell development pathway
Platelet activation, signaling and aggregation pathway
VEGFR2 mediated vascular permeability pathway
Signaling by SCF-KIT pathway
G-protein beta:gamma signalling pathway
deactivation of the beta-catenin transactivating complex pathway
Fc epsilon receptor (FCERI) signaling pathway
Apoptosis pathway
Signal Transduction pathway
GPCR downstream signaling pathway
CD28 co-stimulation pathway
PI3K Cascade pathway
IRS-mediated signalling pathway
AKT phosphorylates targets in the cytosol pathway
Adaptive Immune System pathway
Activation of BH3-only proteins pathway
Immune System pathway
Regulation of gene expression in beta cells pathway
Downstream signal transduction pathway
Insulin receptor signalling cascade pathway
GPVI-mediated activation cascade pathway
TCF dependent signaling in response to WNT pathway
VEGFA-VEGFR2 Pathway pathway
NGF signalling via TRKA from the plasma membrane pathway
IRS-related events triggered by IGF1R pathway
IRS-related events pathway
Translocation of GLUT4 to the plasma membrane pathway
PDE3B signalling pathway
IGF1R signaling cascade pathway
RNF mutants show enhanced WNT signaling and proliferation pathway
Activation of PKB pathway
PI3K/AKT Signaling in Cancer pathway
Signaling by FGFR pathway
CD28 dependent PI3K/Akt signaling pathway
PIP3 activates AKT signaling pathway
Signaling by PDGF pathway
Intrinsic Pathway for Apoptosis pathway
Signaling by Insulin receptor pathway
Signaling by ERBB2 pathway
XAV939 inhibits tankyrase, stabilizing AXIN pathway
Costimulation by the CD28 family pathway
G beta:gamma signalling through PI3Kgamma pathway
Signaling by the B Cell Receptor (BCR) pathway
GAB1 signalosome pathway
CTLA4 inhibitory signaling pathway
Downstream signaling events of B Cell Receptor (BCR) pathway
AKT phosphorylates targets in the nucleus pathway
Negative regulation of the PI3K/AKT network pathway
Disease pathway
Activation of BAD and translocation to mitochondria pathway
Hemostasis pathway
PI3K events in ERBB4 signaling pathway
DAP12 interactions pathway
Membrane Trafficking pathway
KEGG
MAPK signaling pathway pathway
ErbB signaling pathway pathway
Chemokine signaling pathway pathway
mTOR signaling pathway pathway
Apoptosis pathway
VEGF signaling pathway pathway
Osteoclast differentiation pathway
Focal adhesion pathway
Tight junction pathway
Toll-like receptor signaling pathway pathway
Jak-STAT signaling pathway pathway
T cell receptor signaling pathway pathway
B cell receptor signaling pathway pathway
Fc epsilon RI signaling pathway pathway
Fc gamma R-mediated phagocytosis pathway
Neurotrophin signaling pathway pathway
Insulin signaling pathway pathway
Progesterone-mediated oocyte maturation pathway
Adipocytokine signaling pathway pathway
Carbohydrate digestion and absorption pathway
Chagas disease (American trypanosomiasis) pathway
Toxoplasmosis pathway
Hepatitis C pathway
Pathways in cancer pathway
Colorectal cancer pathway
Renal cell carcinoma pathway
Pancreatic cancer pathway
Endometrial cancer pathway
Glioma pathway
Prostate cancer pathway
Melanoma pathway
Chronic myeloid leukemia pathway
Acute myeloid leukemia pathway
Small cell lung cancer pathway
Non-small cell lung cancer pathway
INOH
IGF1 signaling pathway pathway
PDGF signaling pathway pathway
IL-7 signaling pathway
CD4 T cell receptor signaling pathway
JAK STAT pathway and regulation pathway
EPO signaling pathway pathway
Insulin receptor signaling pathway
VEGF signaling pathway pathway
PID BIOCARTA
PID NCI
Class I PI3K signaling events mediated by Akt
Insulin Pathway
Insulin-mediated glucose transport
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.631535 Hs.712583 Hs.736398 Hs.739695
RefSeq NM_001243027 NM_001243028 NM_001626
HUGO
OMIM
CCDS CCDS12552
HPRD 01262
IMGT
EMBL
GenPept
RNA Seq Atlas