Version 5.4
| Bos taurus Gene: AKT2 | |||||||||||||||||||||||||||||||||||||
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| Summary | |||||||||||||||||||||||||||||||||||||
| InnateDB Gene | IDBG-637808.3 | ||||||||||||||||||||||||||||||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||||||||||||||||
| Gene Symbol | AKT2 | ||||||||||||||||||||||||||||||||||||
| Gene Name | RAC-beta serine/threonine-protein kinase | ||||||||||||||||||||||||||||||||||||
| Synonyms | |||||||||||||||||||||||||||||||||||||
| Species | Bos taurus | ||||||||||||||||||||||||||||||||||||
| Ensembl Gene | ENSBTAG00000001400 | ||||||||||||||||||||||||||||||||||||
| Encoded Proteins |
v-akt murine thymoma viral oncogene homolog 2
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| Protein Structure | |||||||||||||||||||||||||||||||||||||
| Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||||||||||||||||||||
| Entrez Gene | |||||||||||||||||||||||||||||||||||||
| Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000105221:
This gene is a putative oncogene encoding a protein belonging to a subfamily of serine/threonine kinases containing SH2-like (Src homology 2-like) domains. The gene was shown to be amplified and overexpressed in 2 of 8 ovarian carcinoma cell lines and 2 of 15 primary ovarian tumors. Overexpression contributes to the malignant phenotype of a subset of human ductal pancreatic cancers. The encoded protein is a general protein kinase capable of phophorylating several known proteins. [provided by RefSeq, Jul 2008] |
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| Gene Information | |||||||||||||||||||||||||||||||||||||
| Type | Protein coding | ||||||||||||||||||||||||||||||||||||
| Genomic Location | Chromosome 18:49904012-49950072 | ||||||||||||||||||||||||||||||||||||
| Strand | Reverse strand | ||||||||||||||||||||||||||||||||||||
| Band | |||||||||||||||||||||||||||||||||||||
| Transcripts |
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| Interactions | |||||||||||||||||||||||||||||||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 53 interaction(s) predicted by orthology.
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| Gene Ontology | |||||||||||||||||||||||||||||||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||||||||||||||||||||||||||||||||
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Species
Homo sapiens
Mus musculus
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Gene ID
Gene Order
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| Pathway Predictions based on Human Orthology Data | |||||||||||||||||||||||||||||||||||||
| NETPATH |
TNFalpha pathway
RANKL pathway
FSH pathway
TWEAK pathway
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| REACTOME |
AKT phosphorylates targets in the nucleus pathway
Negative regulation of the PI3K/AKT network pathway
AKT phosphorylates targets in the cytosol pathway
PIP3 activates AKT signaling pathway
DAP12 signaling pathway
DAP12 interactions pathway
CTLA4 inhibitory signaling pathway
CD28 dependent PI3K/Akt signaling pathway
CD28 co-stimulation pathway
Costimulation by the CD28 family pathway
GPVI-mediated activation cascade pathway
PI3K/AKT activation pathway
Activation of PKB pathway
GAB1 signalosome pathway
Signaling by EGFR pathway
G beta:gamma signalling through PI3Kgamma pathway
PI3K events in ERBB4 signaling pathway
Signaling by ERBB4 pathway
PDE3B signalling pathway
Inhibition of TSC complex formation by PKB pathway
mTOR signalling pathway
PI3K Cascade pathway
Signaling by Insulin receptor pathway
IRS-related events triggered by IGF1R pathway
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) pathway
Downregulation of ERBB2:ERBB3 signaling pathway
PI3K events in ERBB2 signaling pathway
Signaling by ERBB2 pathway
PI-3K cascade pathway
Signaling by FGFR pathway
Signaling by SCF-KIT pathway
Downstream signal transduction pathway
Signaling by PDGF pathway
Activation of BAD and translocation to mitochondria pathway
Constitutive PI3K/AKT Signaling in Cancer pathway
Translocation of GLUT4 to the plasma membrane pathway
AKT-mediated inactivation of FOXO1A pathway
Regulation of gene expression in beta cells pathway
Signaling by FGFR in disease pathway
Developmental Biology pathway
Signalling by NGF pathway
Signaling by EGFR in Cancer pathway
Downstream signaling of activated FGFR pathway
PKB-mediated events pathway
misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling pathway
Signaling by WNT in cancer pathway
Signaling by Wnt pathway
Signaling by VEGF pathway
Role of LAT2/NTAL/LAB on calcium mobilization pathway
Signaling by GPCR pathway
Innate Immune System pathway
Regulation of beta-cell development pathway
Platelet activation, signaling and aggregation pathway
VEGFR2 mediated vascular permeability pathway
G-protein beta:gamma signalling pathway
deactivation of the beta-catenin transactivating complex pathway
Fc epsilon receptor (FCERI) signaling pathway
Apoptosis pathway
Signal Transduction pathway
GPCR downstream signaling pathway
IRS-mediated signalling pathway
Adaptive Immune System pathway
Activation of BH3-only proteins pathway
Immune System pathway
Insulin receptor signalling cascade pathway
TCF dependent signaling in response to WNT pathway
VEGFA-VEGFR2 Pathway pathway
NGF signalling via TRKA from the plasma membrane pathway
IRS-related events pathway
IGF1R signaling cascade pathway
RNF mutants show enhanced WNT signaling and proliferation pathway
PI3K/AKT Signaling in Cancer pathway
Intrinsic Pathway for Apoptosis pathway
XAV939 inhibits tankyrase, stabilizing AXIN pathway
Signaling by the B Cell Receptor (BCR) pathway
Downstream signaling events of B Cell Receptor (BCR) pathway
Disease pathway
Hemostasis pathway
Membrane Trafficking pathway
Disease pathway
Signaling by Wnt pathway
Signaling by Insulin receptor pathway
Signaling by WNT in cancer pathway
Membrane Trafficking pathway
Activation of PKB pathway
Inhibition of TSC complex formation by PKB pathway
deactivation of the beta-catenin transactivating complex pathway
misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling pathway
RNF mutants show enhanced WNT signaling and proliferation pathway
Insulin receptor signalling cascade pathway
IRS-related events triggered by IGF1R pathway
IGF1R signaling cascade pathway
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) pathway
TCF dependent signaling in response to WNT pathway
PI3K Cascade pathway
IRS-related events pathway
IRS-mediated signalling pathway
Signal Transduction pathway
mTOR signalling pathway
PKB-mediated events pathway
Translocation of GLUT4 to the plasma membrane pathway
XAV939 inhibits tankyrase, stabilizing AXIN pathway
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| KEGG |
mTOR signaling pathway pathway
Acute myeloid leukemia pathway
VEGF signaling pathway pathway
Fc epsilon RI signaling pathway pathway
Colorectal cancer pathway
Non-small cell lung cancer pathway
ErbB signaling pathway pathway
Renal cell carcinoma pathway
Apoptosis pathway
MAPK signaling pathway pathway
Melanoma pathway
Endometrial cancer pathway
Tight junction pathway
Glioma pathway
Small cell lung cancer pathway
Insulin signaling pathway pathway
B cell receptor signaling pathway pathway
Prostate cancer pathway
Focal adhesion pathway
T cell receptor signaling pathway pathway
Toll-like receptor signaling pathway pathway
Jak-STAT signaling pathway pathway
Chronic myeloid leukemia pathway
Adipocytokine signaling pathway pathway
Pancreatic cancer pathway
Fc gamma R-mediated phagocytosis pathway
Neurotrophin signaling pathway pathway
Chemokine signaling pathway pathway
Pathways in cancer pathway
Progesterone-mediated oocyte maturation pathway
Chagas disease (American trypanosomiasis) pathway
Osteoclast differentiation pathway
Toxoplasmosis pathway
Carbohydrate digestion and absorption pathway
Hepatitis C pathway
Tight junction pathway
Endometrial cancer pathway
Renal cell carcinoma pathway
ErbB signaling pathway pathway
VEGF signaling pathway pathway
Jak-STAT signaling pathway pathway
Insulin signaling pathway pathway
Acute myeloid leukemia pathway
T cell receptor signaling pathway pathway
Toll-like receptor signaling pathway pathway
Colorectal cancer pathway
Fc epsilon RI signaling pathway pathway
Melanoma pathway
MAPK signaling pathway pathway
Glioma pathway
mTOR signaling pathway pathway
Small cell lung cancer pathway
Adipocytokine signaling pathway pathway
Apoptosis pathway
Prostate cancer pathway
Chronic myeloid leukemia pathway
Non-small cell lung cancer pathway
Focal adhesion pathway
B cell receptor signaling pathway pathway
Pancreatic cancer pathway
Fc gamma R-mediated phagocytosis pathway
Chemokine signaling pathway pathway
Neurotrophin signaling pathway pathway
Pathways in cancer pathway
Progesterone-mediated oocyte maturation pathway
Osteoclast differentiation pathway
Carbohydrate digestion and absorption pathway
Toxoplasmosis pathway
Hepatitis C pathway
Chagas disease (American trypanosomiasis) pathway
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| INOH |
CD4 T cell receptor signaling pathway
IL-7 signaling pathway
JAK STAT pathway and regulation pathway
EPO signaling pathway pathway
Insulin receptor signaling pathway
VEGF signaling pathway pathway
IGF1 signaling pathway pathway
PDGF signaling pathway pathway
CD4 T cell receptor signaling pathway
IL-7 signaling pathway
JAK STAT pathway and regulation pathway
EPO signaling pathway pathway
Insulin receptor signaling pathway
VEGF signaling pathway pathway
PDGF signaling pathway pathway
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| PID NCI |
Class I PI3K signaling events mediated by Akt
Insulin Pathway
Insulin-mediated glucose transport
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| Cross-References | |||||||||||||||||||||||||||||||||||||
| SwissProt | |||||||||||||||||||||||||||||||||||||
| TrEMBL | |||||||||||||||||||||||||||||||||||||
| UniProt Splice Variant | |||||||||||||||||||||||||||||||||||||
| Entrez Gene | |||||||||||||||||||||||||||||||||||||
| UniGene | Bt.6403 | ||||||||||||||||||||||||||||||||||||
| RefSeq | NM_001206146 XM_005218981 XM_005218982 XM_005218983 XM_005218984 | ||||||||||||||||||||||||||||||||||||
| HUGO | |||||||||||||||||||||||||||||||||||||
| OMIM | |||||||||||||||||||||||||||||||||||||
| CCDS | |||||||||||||||||||||||||||||||||||||
| HPRD | |||||||||||||||||||||||||||||||||||||
| IMGT | |||||||||||||||||||||||||||||||||||||
| EMBL | |||||||||||||||||||||||||||||||||||||
| GenPept | |||||||||||||||||||||||||||||||||||||
| RNA Seq Atlas | |||||||||||||||||||||||||||||||||||||