Version 5.4
Homo sapiens Gene: PLA1A
Summary
InnateDB Gene IDBG-51365.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PLA1A
Gene Name phospholipase A1 member A
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000144837
Encoded Proteins
IDBP-51367
phospholipase A1 member A
IDBP-481144
phospholipase A1 member A
IDBP-484168
phospholipase A1 member A
IDBP-475858
phospholipase A1 member A
IDBP-482380
phospholipase A1 member A
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a phospholipase that hydrolyzes fatty acids at the sn-1 position of phosphatidylserine and 1-acyl-2-lysophosphatidylserine. This secreted protein hydrolyzes phosphatidylserine in liposomes. Three transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, May 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:119597842-119629811
Strand Forward strand
Band q13.33
Transcripts
ENST00000273371 ENSP00000273371
ENST00000488919 ENSP00000420625
ENST00000495992 ENSP00000417326
ENST00000472126
ENST00000494440 ENSP00000418793
ENST00000475963 ENSP00000417295
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 1 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0008970 phosphatidylcholine 1-acylhydrolase activity
GO:0016787 hydrolase activity
GO:0052689 carboxylic ester hydrolase activity
Biological Process
GO:0006629 lipid metabolic process
GO:0006658 phosphatidylserine metabolic process
GO:0016042 lipid catabolic process
Cellular Component
GO:0005576 extracellular region
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000002847
View Gene Order
ENSBTAG00000009392
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.437451 Hs.714096
RefSeq NM_001206960 NM_001206961 NM_001293225 NM_015900
HUGO
OMIM
CCDS CCDS2991 CCDS56268 CCDS56269
HPRD 07078
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca