Version 5.4
Homo sapiens Protein: PLA1A
Summary
InnateDB Protein IDBP-484168.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PLA1A
Protein Name phospholipase A1 member A
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000417326
InnateDB Gene IDBG-51365 (PLA1A)
Protein Structure
UniProt Annotation
Function Hydrolyzes the ester bond at the sn-1 position of glycerophospholipids and produces 2-acyl lysophospholipids. Hydrolyzes phosphatidylserine (PS) in the form of liposomes and 1- acyl-2 lysophosphatidylserine (lyso-PS), but not triolein, phosphatidylcholine (PC), phosphatidylethanolamine (PE), phosphatidic acid (PA) or phosphatidylinositol (PI). Isoform 2 hydrolyzes lyso-PS but not PS. Hydrolysis of lyso-PS in peritoneal mast cells activated by receptors for IgE leads to stimulate histamine production. {ECO:0000269PubMed:10196188}.
Subcellular Localization Secreted {ECO:0000305}.
Disease Associations
Tissue Specificity Widely expressed. Expressed in placenta, prostate and liver. Weakly or not expressed in skin, leukocytes, platelets, colon, spleen, lung, muscle and kidney. {ECO:0000269PubMed:9074642}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 1 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0008970 phosphatidylcholine 1-acylhydrolase activity
GO:0052689 carboxylic ester hydrolase activity
Biological Process
GO:0006629 lipid metabolic process
GO:0006658 phosphatidylserine metabolic process
GO:0016042 lipid catabolic process
Cellular Component
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR000734 Lipase
IPR013818 Lipase, N-terminal
IPR016272 Lipoprotein lipase, LIPH
IPR029058 Alpha/Beta hydrolase fold
PFAM PF00151
PRINTS PR00821
PIRSF PIRSF000865
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q53H76
PhosphoSite PhosphoSite-Q53H76
TrEMBL
UniProt Splice Variant
Entrez Gene 51365
UniGene Hs.714096
RefSeq NP_001193889
HUGO HGNC:17661
OMIM 607460
CCDS CCDS56268
HPRD 07078
IMGT
EMBL AC073352 AF035268 AF035269 AK222705 AK301880 AK313519 BC047703 CH471052 U37591
GenPept AAC98921 AAC98922 AAC99994 AAH47703 BAD96425 BAG36299 BAG63314 EAW79557

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca