InnateDB Protein
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IDBP-484168.4
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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PLA1A
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Protein Name
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phospholipase A1 member A
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000417326
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InnateDB Gene
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IDBG-51365 (PLA1A)
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Protein Structure
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Function |
Hydrolyzes the ester bond at the sn-1 position of glycerophospholipids and produces 2-acyl lysophospholipids. Hydrolyzes phosphatidylserine (PS) in the form of liposomes and 1- acyl-2 lysophosphatidylserine (lyso-PS), but not triolein, phosphatidylcholine (PC), phosphatidylethanolamine (PE), phosphatidic acid (PA) or phosphatidylinositol (PI). Isoform 2 hydrolyzes lyso-PS but not PS. Hydrolysis of lyso-PS in peritoneal mast cells activated by receptors for IgE leads to stimulate histamine production. {ECO:0000269PubMed:10196188}.
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Subcellular Localization |
Secreted {ECO:0000305}.
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Disease Associations |
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Tissue Specificity |
Widely expressed. Expressed in placenta, prostate and liver. Weakly or not expressed in skin, leukocytes, platelets, colon, spleen, lung, muscle and kidney. {ECO:0000269PubMed:9074642}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
2
[view]
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Protein-Protein |
1
[view]
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Protein-DNA |
1
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
Accession |
GO Term |
GO:0008970
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phosphatidylcholine 1-acylhydrolase activity
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GO:0052689
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carboxylic ester hydrolase activity
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR000734
Lipase
IPR013818
Lipase, N-terminal
IPR016272
Lipoprotein lipase, LIPH
IPR029058
Alpha/Beta hydrolase fold
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PFAM |
PF00151
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PRINTS |
PR00821
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PIRSF |
PIRSF000865
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q53H76
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PhosphoSite |
PhosphoSite-Q53H76
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
51365
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UniGene |
Hs.714096
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RefSeq |
NP_001193889
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HUGO |
HGNC:17661
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OMIM |
607460
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CCDS |
CCDS56268
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HPRD |
07078
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IMGT |
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EMBL |
AC073352
AF035268
AF035269
AK222705
AK301880
AK313519
BC047703
CH471052
U37591
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GenPept |
AAC98921
AAC98922
AAC99994
AAH47703
BAD96425
BAG36299
BAG63314
EAW79557
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