Homo sapiens Gene: FSHR
Summary
InnateDB Gene IDBG-51448.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol FSHR
Gene Name follicle stimulating hormone receptor
Synonyms FSHRO; LGR1; ODG1;
Species Homo sapiens
Ensembl Gene ENSG00000170820
Encoded Proteins
follicle stimulating hormone receptor
follicle stimulating hormone receptor
follicle stimulating hormone receptor
follicle stimulating hormone receptor
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene belongs to family 1 of G-protein coupled receptors. It is the receptor for follicle stimulating hormone and functions in gonad development. Mutations in this gene cause ovarian dysgenesis type 1, and also ovarian hyperstimulation syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:48962157-49154537
Strand Reverse strand
Band p16.3
Transcripts
ENST00000304421 ENSP00000306780
ENST00000406846 ENSP00000384708
ENST00000454032 ENSP00000415504
ENST00000419927 ENSP00000405775
ENST00000469138
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 22 experimentally validated interaction(s) in this database.
Experimentally validated
Total 22 [view]
Protein-Protein 22 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004930 G-protein coupled receptor activity
GO:0004963 follicle-stimulating hormone receptor activity
GO:0005515 protein binding
GO:0017046 peptide hormone binding
Biological Process
GO:0001541 ovarian follicle development
GO:0001545 primary ovarian follicle growth
GO:0001932 regulation of protein phosphorylation
GO:0003073 regulation of systemic arterial blood pressure
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007188 adenylate cyclase-modulating G-protein coupled receptor signaling pathway
GO:0007189 adenylate cyclase-activating G-protein coupled receptor signaling pathway
GO:0007193 adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
GO:0007200 phospholipase C-activating G-protein coupled receptor signaling pathway
GO:0007283 spermatogenesis
GO:0007286 spermatid development
GO:0007292 female gamete generation
GO:0007626 locomotory behavior
GO:0008406 gonad development
GO:0008584 male gonad development
GO:0008585 female gonad development
GO:0009992 cellular water homeostasis
GO:0010640 regulation of platelet-derived growth factor receptor signaling pathway
GO:0022602 ovulation cycle process
GO:0031175 neuron projection development
GO:0032350 regulation of hormone metabolic process
GO:0033044 regulation of chromosome organization
GO:0033146 regulation of intracellular estrogen receptor signaling pathway
GO:0033148 positive regulation of intracellular estrogen receptor signaling pathway
GO:0035092 sperm chromatin condensation
GO:0035093 spermatogenesis, exchange of chromosomal proteins
GO:0042699 follicle-stimulating hormone signaling pathway
GO:0043408 regulation of MAPK cascade
GO:0045056 transcytosis
GO:0045670 regulation of osteoclast differentiation
GO:0045779 negative regulation of bone resorption
GO:0060009 Sertoli cell development
GO:0060011 Sertoli cell proliferation
GO:0060065 uterus development
GO:0060408 regulation of acetylcholine metabolic process
GO:0071711 basement membrane organization
Cellular Component
GO:0005768 endosome
GO:0005886 plasma membrane
GO:0009986 cell surface
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
FSH pathway
REACTOME
G alpha (s) signalling events pathway
Class A/1 (Rhodopsin-like receptors) pathway
Signaling by GPCR pathway
Signal Transduction pathway
GPCR downstream signaling pathway
Hormone ligand-binding receptors pathway
GPCR ligand binding pathway
KEGG
Neuroactive ligand-receptor interaction pathway
INOH
PID BIOCARTA
Regulation of spermatogenesis by crem [Biocarta view]
PID NCI
Cross-References
SwissProt
TrEMBL F8WBM4
UniProt Splice Variant
Entrez Gene 2492
UniGene Hs.1428
RefSeq NM_181446 NM_000145
HUGO HGNC:3969
OMIM 136435
CCDS CCDS1844 CCDS1843
HPRD 00639
IMGT
EMBL AC007189 AC079394 AC092533
GenPept
RNA Seq Atlas 2492