InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: ARHGAP26

Summary

InnateDB Gene

IDBG-51453.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ARHGAP26

Gene Name

Rho GTPase activating protein 26

Synonyms

GRAF; GRAF1; OPHN1L; OPHN1L1

Species

Homo sapiens

Ensembl Gene

ENSG00000145819

Encoded Proteins

IDBP-51455

Rho GTPase activating protein 26

IDBP-51457

Rho GTPase activating protein 26

IDBP-51459

Rho GTPase activating protein 26

IDBP-379266

Rho GTPase activating protein 26

IDBP-379268

Rho GTPase activating protein 26

IDBP-379275

Rho GTPase activating protein 26

IDBP-379277

Rho GTPase activating protein 26

IDBP-379278

Rho GTPase activating protein 26

IDBP-379284

Rho GTPase activating protein 26

IDBP-379285

Rho GTPase activating protein 26

IDBP-379287

Rho GTPase activating protein 26

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

Interaction of a cell with the extracellular matrix triggers integrin cell surface receptors to begin signaling cascades that regulate the organization of the actin-cytoskeleton. One of the proteins involved in these cascades is focal adhesion kinase. The protein encoded by this gene is a GTPase activating protein that binds to focal adhesion kinase and mediates the activity of the GTP binding proteins RhoA and Cdc42. Defects in this gene are a cause of juvenile myelomonocytic leukemia (JMML). Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 5:142770384-143229011

Strand

Forward strand

Band

q31.3

Transcripts

ENST00000378013	ENSP00000367252
ENST00000378004	ENSP00000367243
ENST00000274498	ENSP00000274498
ENST00000451259	ENSP00000411571
ENST00000443674	ENSP00000393276
ENST00000418236	ENSP00000416889
ENST00000443045	ENSP00000392186
ENST00000419676	ENSP00000413283
ENST00000424007	ENSP00000400565
ENST00000421521	ENSP00000389137
ENST00000425417	ENSP00000403388
ENST00000475287
ENST00000477867
ENST00000461314
ENST00000469131
ENST00000469396
ENST00000464838
ENST00000470032
ENST00000489924
ENST00000486650

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.

Experimentally validated
Total	11 [view]
Protein-Protein	11 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005100	Rho GTPase activator activity
GO:0005515	protein binding
GO:0005543	phospholipid binding
GO:0008093	cytoskeletal adaptor activity
GO:0017124	SH3 domain binding

Biological Process

GO:0007009	plasma membrane organization
GO:0007165	signal transduction
GO:0007264	small GTPase mediated signal transduction
GO:0007399	nervous system development
GO:0030036	actin cytoskeleton organization
GO:0032321	positive regulation of Rho GTPase activity
GO:0046847	filopodium assembly
GO:0051056	regulation of small GTPase mediated signal transduction

Cellular Component

GO:0005575	cellular_component
GO:0005622	intracellular
GO:0005829	cytosol
GO:0005856	cytoskeleton
GO:0005925	focal adhesion

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000036452

View Gene Order

ENSBTAG00000027151

Not yet available

Pathways

NETPATH

REACTOME

REACT_11051

Rho GTPase cycle pathway

REACT_11044

Signaling by Rho GTPases pathway

REACT_111102

Signal Transduction pathway

KEGG

INOH

PID NCI

fak_pathway

Signaling events mediated by focal adhesion kinase

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.610471 Hs.713808

RefSeq

NM_001135608 NM_015071 XM_005268399

HUGO

OMIM

CCDS

CCDS4277 CCDS47297

HPRD

05643

IMGT

EMBL

GenPept

RNA Seq Atlas