InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ARHGAP26

Summary

InnateDB Protein

IDBP-51457.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ARHGAP26

Protein Name

Rho GTPase activating protein 26

Synonyms

GRAF; GRAF1; OPHN1L; OPHN1L1;

Species

Homo sapiens

Ensembl Protein

ENSP00000367243

InnateDB Gene

IDBG-51453 (ARHGAP26)

Protein Structure

UniProt Annotation

Function

GTPase-activating protein for RHOA and CDC42.

Subcellular Localization

Cell junction, focal adhesion {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}. Note=Colocalizes with actin stress fibers and cortical actin structures. {ECO:0000250}.

Disease Associations

Leukemia, juvenile myelomonocytic (JMML) [MIM:607785]: An aggressive pediatric myelodysplastic syndrome/myeloproliferative disorder characterized by malignant transformation in the hematopoietic stem cell compartment with proliferation of differentiated progeny. Patients have splenomegaly, enlarged lymph nodes, rashes, and hemorrhages. Note=The gene represented in this entry is involved in disease pathogenesis. A chromosomal translocation t(5;11)(q31;q23) with KMT2A/MLL1 has been found in leukemic cells from JMML patients, also carrying inactivating mutations on the second allele (PubMed:10908648). {ECO:0000269PubMed:10908648}.

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.

Experimentally validated
Total	11 [view]
Protein-Protein	11 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005100	Rho GTPase activator activity
GO:0005515	protein binding
GO:0005543	phospholipid binding
GO:0008093	cytoskeletal adaptor activity
GO:0017124	SH3 domain binding

Biological Process

GO:0007009	plasma membrane organization
GO:0007165	signal transduction
GO:0007264	small GTPase mediated signal transduction
GO:0007399	nervous system development
GO:0030036	actin cytoskeleton organization
GO:0032321	positive regulation of Rho GTPase activity
GO:0046847	filopodium assembly
GO:0051056	regulation of small GTPase mediated signal transduction

Cellular Component

GO:0005575	cellular_component
GO:0005622	intracellular
GO:0005829	cytosol
GO:0005856	cytoskeleton
GO:0005925	focal adhesion

Protein Structure and Domains

PDB ID

InterPro

IPR000198 Rho GTPase-activating protein domain
IPR001452 SH3 domain
IPR001849 Pleckstrin homology domain
IPR008936 Rho GTPase activation protein
IPR011511 Variant SH3 domain
IPR013606 IRSp53/MIM homology domain (IMD)

PFAM

PF00620
PF00018
PF14604
PF00169
PF07653
PF08397

PRINTS

PR00452

PIRSF

SMART

SM00324
SM00326
SM00233

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt