Homo sapiens Gene: SOX1
Summary
InnateDB Gene IDBG-51536.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SOX1
Gene Name SRY (sex determining region Y)-box 1
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000182968
Encoded Proteins
SRY (sex determining region Y)-box 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This intronless gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional activator after forming a protein complex with other proteins. In mice, a similar protein regulates the gamma-crystallin genes and is essential for lens development. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 13:112067647-112070488
Strand Forward strand
Band q34
Transcripts
ENST00000330949 ENSP00000330218
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0001046 core promoter sequence-specific DNA binding
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0005515 protein binding
GO:0043565 sequence-specific DNA binding
Biological Process
GO:0001764 neuron migration
GO:0002089 lens morphogenesis in camera-type eye
GO:0006325 chromatin organization
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0021521 ventral spinal cord interneuron specification
GO:0021879 forebrain neuron differentiation
GO:0021884 forebrain neuron development
GO:0030900 forebrain development
Cellular Component
GO:0005634 nucleus
Orthologs
Species
Bos taurus
Mus musculus
Gene ID
Gene Order
Method
Confidence
Comments
Not yet available
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Pathways
NETPATH
Wnt pathway
REACTOME
KEGG
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt O00570
TrEMBL
UniProt Splice Variant
Entrez Gene 6656
UniGene Hs.202526 Hs.611638
RefSeq NM_005986
HUGO HGNC:11189
OMIM 602148
CCDS CCDS9523
HPRD 03687
IMGT
EMBL AL138691 CH471085 Y13436
GenPept CAA73847 CAH72340 EAX09158
RNA Seq Atlas 6656