Homo sapiens Gene: ERLEC1
Summary
InnateDB Gene IDBG-51695.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ERLEC1
Gene Name endoplasmic reticulum lectin 1
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000068912
Encoded Proteins
endoplasmic reticulum lectin 1
endoplasmic reticulum lectin 1
endoplasmic reticulum lectin 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a resident endoplasmic reticulum (ER) protein that functions in N-glycan recognition. This protein is thought to be involved in ER-associated degradation via its interaction with the membrane-associated ubiquitin ligase complex. It also functions as a regulator of multiple cellular stress-response pathways in a manner that promotes metastatic cell survival. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 21. [provided by RefSeq, Aug 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:53787044-53818819
Strand Forward strand
Band p16.2
Transcripts
ENST00000378239 ENSP00000367485
ENST00000185150 ENSP00000185150
ENST00000405123 ENSP00000385629
ENST00000494373
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.
Experimentally validated
Total 15 [view]
Protein-Protein 15 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0001948 glycoprotein binding
GO:0005515 protein binding
Biological Process
GO:0030433 ER-associated ubiquitin-dependent protein catabolic process
Cellular Component
GO:0005788 endoplasmic reticulum lumen
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Processing-defective Hh variants abrogate ligand secretion pathway
Signaling by Hedgehog pathway
Signal Transduction pathway
Hh ligand biogenesis disease pathway
Hedgehog ligand biogenesis pathway
Disease pathway
KEGG
Protein processing in endoplasmic reticulum pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.438336
RefSeq NM_001127397 NM_001127398 NM_015701
HUGO
OMIM
CCDS CCDS1848 CCDS46283 CCDS46284
HPRD 10310
IMGT
EMBL
GenPept
RNA Seq Atlas