Homo sapiens Gene: LARS
Summary
InnateDB Gene IDBG-51947.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol LARS
Gene Name leucyl-tRNA synthetase
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000133706
Encoded Proteins
leucyl-tRNA synthetase
leucyl-tRNA synthetase
leucyl-tRNA synthetase
leucyl-tRNA synthetase
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a cytosolic leucine-tRNA synthetase, a member of the class I aminoacyl-tRNA synthetase family. The encoded enzyme catalyzes the ATP-dependent ligation of L-leucine to tRNA(Leu). It is found in the cytoplasm as part of a multisynthetase complex and interacts with the arginine tRNA synthetase through its C-terminal domain. Alternatively spliced transcript variants of this gene have been found; however, their full-length nature is not known. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:146113038-146182660
Strand Reverse strand
Band q32
Transcripts
ENST00000274562 ENSP00000274562
ENST00000394434 ENSP00000377954
ENST00000510191 ENSP00000426005
ENST00000506231
ENST00000508709
ENST00000504611
ENST00000512412
ENST00000514104
ENST00000504323
ENST00000508667
ENST00000507095
ENST00000511505
ENST00000505223
ENST00000503654
ENST00000506436
ENST00000618084 ENSP00000481381
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 44 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 44 [view]
Protein-Protein 44 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0002161 aminoacyl-tRNA editing activity
GO:0004812 aminoacyl-tRNA ligase activity
GO:0004823 leucine-tRNA ligase activity
GO:0005515 protein binding
GO:0005524 ATP binding
Biological Process
GO:0006418 tRNA aminoacylation for protein translation
GO:0006429 leucyl-tRNA aminoacylation
GO:0006450 regulation of translational fidelity
GO:0010467 gene expression
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Cytosolic tRNA aminoacylation pathway
tRNA Aminoacylation pathway
Gene Expression pathway
KEGG
Aminoacyl-tRNA biosynthesis pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene 51520
UniGene
RefSeq NM_020117
HUGO HGNC:6512
OMIM 151350
CCDS CCDS34265
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas 102724915 102724932 51520