InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: LARS

Summary

InnateDB Protein

IDBP-480587.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

LARS

Protein Name

leucyl-tRNA synthetase

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000426005

InnateDB Gene

IDBG-51947 (LARS)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 44 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	44 [view]
Protein-Protein	44 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0002161	aminoacyl-tRNA editing activity
GO:0004812	aminoacyl-tRNA ligase activity
GO:0004823	leucine-tRNA ligase activity
GO:0005524	ATP binding

Biological Process

GO:0006418	tRNA aminoacylation for protein translation
GO:0006429	leucyl-tRNA aminoacylation
GO:0006450	regulation of translational fidelity

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm

Protein Structure and Domains

PDB ID

InterPro

IPR002300 Aminoacyl-tRNA synthetase, class Ia
IPR004493 Leucyl-tRNA synthetase, class Ia, archaeal/eukaryotic cytosolic
IPR009008 Valyl/Leucyl/Isoleucyl-tRNA synthetase, editing domain
IPR009080 Aminoacyl-tRNA synthetase, class 1a, anticodon-binding
IPR013155 Valyl/Leucyl/Isoleucyl-tRNA synthetase, anticodon-binding
IPR015413 Methionyl/Leucyl tRNA synthetase
IPR024909 Cysteinyl-tRNA synthetase/mycothiol ligase

PFAM

PF00133
PF08264
PF09334
PF01406

PRINTS

PR00983

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite