Homo sapiens Gene: ELK3
Summary
InnateDB Gene IDBG-52037.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ELK3
Gene Name ELK3, ETS-domain protein (SRF accessory protein 2)
Synonyms ERP; NET; SAP2;
Species Homo sapiens
Ensembl Gene ENSG00000111145
Encoded Proteins
ELK3, ETS-domain protein (SRF accessory protein 2)
ELK3, ETS-domain protein (SRF accessory protein 2)
ELK3, ETS-domain protein (SRF accessory protein 2)
ELK3, ETS-domain protein (SRF accessory protein 2)
ELK3, ETS-domain protein (SRF accessory protein 2)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a member of the ETS-domain transcription factor family and the ternary complex factor (TCF) subfamily. Proteins in this subfamily regulate transcription when recruited by serum response factor to bind to serum response elements. This protein is activated by signal-induced phosphorylation; studies in rodents suggest that it is a transcriptional inhibitor in the absence of Ras, but activates transcription when Ras is present. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:96194382-96269835
Strand Forward strand
Band q23.1
Transcripts
ENST00000228741 ENSP00000228741
ENST00000547249 ENSP00000446806
ENST00000552142 ENSP00000449430
ENST00000547860 ENSP00000447857
ENST00000549985 ENSP00000449420
ENST00000549529
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 6 [view]
Protein-Protein 5 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0000981 sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0001077 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0003714 transcription corepressor activity
GO:0005515 protein binding
GO:0032422 purine-rich negative regulatory element binding
GO:0043565 sequence-specific DNA binding
Biological Process
GO:0001525 angiogenesis
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0006366 transcription from RNA polymerase II promoter
GO:0007165 signal transduction
GO:0030154 cell differentiation
GO:0042060 wound healing
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
Cellular Component
GO:0005634 nucleus
GO:0005739 mitochondrion
GO:0043231 intracellular membrane-bounded organelle
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
ID pathway
REACTOME
KEGG
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL F8VZQ0 G3V1Z7
UniProt Splice Variant
Entrez Gene 2004
UniGene Hs.46523 Hs.718709 Hs.733727
RefSeq NM_005230 XM_006719275
HUGO HGNC:3325
OMIM 600247
CCDS CCDS9060
HPRD 02593
IMGT
EMBL AC008149 CH471054
GenPept EAW97562
RNA Seq Atlas 2004