InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: ELK3

Summary

InnateDB Gene

IDBG-52037.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ELK3

Gene Name

ELK3, ETS-domain protein (SRF accessory protein 2)

Synonyms

ERP; NET; SAP2

Species

Homo sapiens

Ensembl Gene

ENSG00000111145

Encoded Proteins

IDBP-52039

ELK3, ETS-domain protein (SRF accessory protein 2)

IDBP-588899

ELK3, ETS-domain protein (SRF accessory protein 2)

IDBP-593373

ELK3, ETS-domain protein (SRF accessory protein 2)

IDBP-602783

ELK3, ETS-domain protein (SRF accessory protein 2)

IDBP-602847

ELK3, ETS-domain protein (SRF accessory protein 2)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The protein encoded by this gene is a member of the ETS-domain transcription factor family and the ternary complex factor (TCF) subfamily. Proteins in this subfamily regulate transcription when recruited by serum response factor to bind to serum response elements. This protein is activated by signal-induced phosphorylation; studies in rodents suggest that it is a transcriptional inhibitor in the absence of Ras, but activates transcription when Ras is present. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 12:96194382-96269835

Strand

Forward strand

Band

q23.1

Transcripts

ENST00000228741	ENSP00000228741
ENST00000547249	ENSP00000446806
ENST00000552142	ENSP00000449430
ENST00000547860	ENSP00000447857
ENST00000549985	ENSP00000449420
ENST00000549529

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	6 [view]
Protein-Protein	5 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0000981	sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0001077	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0003714	transcription corepressor activity
GO:0005515	protein binding
GO:0032422	purine-rich negative regulatory element binding
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0001525	angiogenesis
GO:0006355	regulation of transcription, DNA-templated
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0006366	transcription from RNA polymerase II promoter
GO:0007165	signal transduction
GO:0030154	cell differentiation
GO:0042060	wound healing
GO:0045892	negative regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter

Cellular Component

GO:0005634	nucleus
GO:0005739	mitochondrion
GO:0043231	intracellular membrane-bounded organelle

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000008398

View Gene Order

ENSBTAG00000001509

Not yet available

Pathways

NETPATH

NetPath_5

ID pathway

REACTOME

KEGG

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.46523 Hs.718709 Hs.733727

RefSeq

NM_005230 XM_006719275

HUGO

OMIM

CCDS

CCDS9060

HPRD

02593

IMGT

EMBL

GenPept

RNA Seq Atlas