Version 5.4
Mus musculus Gene: Elk3
Summary
InnateDB Gene IDBG-185812.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Elk3
Gene Name ELK3, member of ETS oncogene family
Synonyms D430049E23Rik; Erp; Etrp; Net; Sap-2
Species Mus musculus
Ensembl Gene ENSMUSG00000008398
Encoded Proteins
IDBP-185814
ELK3, member of ETS oncogene family
IDBP-532715
ELK3, member of ETS oncogene family
IDBP-533049
ELK3, member of ETS oncogene family
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000111145:
The protein encoded by this gene is a member of the ETS-domain transcription factor family and the ternary complex factor (TCF) subfamily. Proteins in this subfamily regulate transcription when recruited by serum response factor to bind to serum response elements. This protein is activated by signal-induced phosphorylation; studies in rodents suggest that it is a transcriptional inhibitor in the absence of Ras, but activates transcription when Ras is present. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 10:93247414-93311135
Strand Reverse strand
Band C2
Transcripts
ENSMUST00000008542 ENSMUSP00000008542
ENSMUST00000151153 ENSMUSP00000121754
ENSMUST00000129827 ENSMUSP00000122324
ENSMUST00000133365
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 0
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 8 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0000981 sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0001077 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0003714 transcription corepressor activity
GO:0005515 protein binding
GO:0032422 purine-rich negative regulatory element binding
GO:0043565 sequence-specific DNA binding
Biological Process
GO:0001525 angiogenesis
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0006366 transcription from RNA polymerase II promoter
GO:0030154 cell differentiation
GO:0042060 wound healing
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
Cellular Component
GO:0005634 nucleus
GO:0005739 mitochondrion
GO:0043231 intracellular membrane-bounded organelle
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000111145
View Gene Order
ENSBTAG00000001509
Not yet available
Pathways
NETPATH
REACTOME
KEGG
INOH
INOH website
FGF8 signaling (Mouse) pathway
INOH website
FGF signaling pathway pathway
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_5
ID pathway
REACTOME
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL A9L8S9 G3UVX2
UniProt Splice Variant
Entrez Gene 13713
UniGene Mm.4454 Mm.472341
RefSeq NM_001282967 NM_013508
OMIM
CCDS CCDS24124 CCDS70097
HPRD
IMGT
MGI ID MGI:101762
MGI Symbol Elk3
EMBL AC140379 AC161054 CH466539 D26065
GenPept BAF93848 EDL21548
RNA Seq Atlas 13713

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca