Version 5.4
Homo sapiens Gene: CRLS1
Summary
InnateDB Gene IDBG-52150.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CRLS1
Gene Name cardiolipin synthase 1
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000088766
Encoded Proteins
IDBP-52152
cardiolipin synthase 1
IDBP-52154
cardiolipin synthase 1
IDBP-365461
cardiolipin synthase 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 20:6006090-6040053
Strand Forward strand
Band p12.3
Transcripts
ENST00000378868 ENSP00000368145
ENST00000378863 ENSP00000368140
ENST00000452938 ENSP00000416770
ENST00000489345
ENST00000464921
ENST00000478846
ENST00000609154
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0008444 CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity
GO:0016780 phosphotransferase activity, for other substituted phosphate groups
Biological Process
GO:0006644 phospholipid metabolic process
GO:0008654 phospholipid biosynthetic process
GO:0032049 cardiolipin biosynthetic process
GO:0036148 phosphatidylglycerol acyl-chain remodeling
GO:0044281 small molecule metabolic process
GO:0046474 glycerophospholipid biosynthetic process
Cellular Component
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000027357
View Gene Order
ENSBTAG00000000065
Not yet available
Pathways
NETPATH
REACTOME
REACT_120920
Synthesis of CL pathway
REACT_121324
Acyl chain remodelling of PG pathway
REACT_22258
Metabolism of lipids and lipoproteins pathway
REACT_121401
Glycerophospholipid biosynthesis pathway
REACT_120870
Phospholipid metabolism pathway
REACT_111217
Metabolism pathway
KEGG
hsa00564
Glycerophospholipid metabolism pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL Q6NTG3
UniProt Splice Variant
Entrez Gene 54675
UniGene Hs.224764 Hs.706380 Hs.729807
RefSeq NM_001127458 NM_019095 XM_005260737 XM_005260738 XM_006723579 XM_006723580
HUGO HGNC:16148
OMIM 608188
CCDS CCDS13096 CCDS46578
HPRD 12187
IMGT
EMBL AL035461 BC069010 CH471133
GenPept AAH69010 EAX10400
RNA Seq Atlas 54675

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca