InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CRLS1

Summary

InnateDB Protein

IDBP-52154.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CRLS1

Protein Name

cardiolipin synthase 1

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000368140

InnateDB Gene

IDBG-52150 (CRLS1)

Protein Structure

UniProt Annotation

Function

Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol. {ECO:0000269PubMed:16547353, ECO:0000269PubMed:16678169}.

Subcellular Localization

Mitochondrion inner membrane {ECO:0000269PubMed:16547353}; Multi-pass membrane protein {ECO:0000269PubMed:16547353}.

Disease Associations

Tissue Specificity

Highly expressed in tissues such as heart, skeletal muscle and liver. {ECO:0000269PubMed:16547353}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0016780	phosphotransferase activity, for other substituted phosphate groups

Biological Process

GO:0006644	phospholipid metabolic process
GO:0008654	phospholipid biosynthetic process
GO:0032049	cardiolipin biosynthetic process
GO:0036148	phosphatidylglycerol acyl-chain remodeling
GO:0044281	small molecule metabolic process
GO:0046474	glycerophospholipid biosynthetic process