Homo sapiens Gene: F7
Summary
InnateDB Gene IDBG-52192.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol F7
Gene Name coagulation factor VII (serum prothrombin conversion accelerator)
Synonyms SPCA;
Species Homo sapiens
Ensembl Gene ENSG00000057593
Encoded Proteins
coagulation factor VII (serum prothrombin conversion accelerator)
coagulation factor VII (serum prothrombin conversion accelerator)
coagulation factor VII (serum prothrombin conversion accelerator)
coagulation factor VII (serum prothrombin conversion accelerator)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes coagulation factor VII which is a vitamin K-dependent factor essential for hemostasis. This factor circulates in the blood in a zymogen form, and is converted to an active form by either factor IXa, factor Xa, factor XIIa, or thrombin by minor proteolysis. Upon activation of the factor VII, a heavy chain containing a catalytic domain and a light chain containing 2 EGF-like domains are generated, and two chains are held together by a disulfide bond. In the presence of factor III and calcium ions, the activated factor then further activates the coagulation cascade by converting factor IX to factor IXa and/or factor X to factor Xa. Defects in this gene can cause coagulopathy. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, May 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 13:113105788-113120681
Strand Forward strand
Band q34
Transcripts
ENST00000346342 ENSP00000329546
ENST00000375581 ENSP00000364731
ENST00000444337 ENSP00000387669
ENST00000479674
ENST00000473085
ENST00000541084 ENSP00000442051
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.
Experimentally validated
Total 15 [view]
Protein-Protein 14 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0001948 glycoprotein binding
GO:0003824 catalytic activity
GO:0004175 endopeptidase activity
GO:0004252 serine-type endopeptidase activity
GO:0005102 receptor binding
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0008236 serine-type peptidase activity
Biological Process
GO:0002690 positive regulation of leukocyte chemotaxis
GO:0006508 proteolysis
GO:0007596 blood coagulation
GO:0007598 blood coagulation, extrinsic pathway
GO:0007623 circadian rhythm
GO:0009725 response to hormone
GO:0010641 positive regulation of platelet-derived growth factor receptor signaling pathway
GO:0014070 response to organic cyclic compound
GO:0017187 peptidyl-glutamic acid carboxylation
GO:0030194 positive regulation of blood coagulation
GO:0030335 positive regulation of cell migration
GO:0031100 organ regeneration
GO:0031667 response to nutrient levels
GO:0032571 response to vitamin K
GO:0043627 response to estrogen
GO:0043687 post-translational protein modification
GO:0044267 cellular protein metabolic process
GO:0050927 positive regulation of positive chemotaxis
GO:0051897 positive regulation of protein kinase B signaling
GO:0060416 response to growth hormone
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005788 endoplasmic reticulum lumen
GO:0005796 Golgi lumen
GO:0005886 plasma membrane
GO:0031982 vesicle
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Circadian Clock pathway
Post-translational protein modification pathway
Gamma-carboxylation, transport, and amino-terminal cleavage of proteins pathway
Formation of Fibrin Clot (Clotting Cascade) pathway
PTM: gamma carboxylation, hypusine formation and arylsulfatase activation pathway
BMAL1:CLOCK,NPAS2 activates circadian gene expression pathway
Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus pathway
Metabolism of proteins pathway
Extrinsic Pathway pathway
Removal of aminoterminal propeptides from gamma-carboxylated proteins pathway
Gamma-carboxylation of protein precursors pathway
Hemostasis pathway
KEGG
Complement and coagulation cascades pathway
INOH
PID BIOCARTA
Extrinsic prothrombin activation pathway [Biocarta view]
PID NCI
Cross-References
SwissProt P08709
TrEMBL A3RKG7 Q9UMU6
UniProt Splice Variant
Entrez Gene 2155
UniGene Hs.36989
RefSeq NM_000131 NM_019616 NM_001267554
HUGO HGNC:3544
OMIM 613878
CCDS CCDS9528 CCDS9529 CCDS73602
HPRD 01965
IMGT
EMBL AF466933 AL137002 AY212252 BC130468 DQ142911 EF421855 EF445049 EU557239 J02933 M13232 U14580
GenPept AAA51983 AAA88040 AAA88041 AAC50211 AAI30469 AAL66184 AAP33841 ABD17891 ABN79862 ACA06107 ACA06108 ACB87203 CAI41381 CAI41382
RNA Seq Atlas 2155