InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: F7

Summary

InnateDB Gene

IDBG-52192.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Gene Name

coagulation factor VII (serum prothrombin conversion accelerator)

Synonyms

SPCA

Species

Homo sapiens

Ensembl Gene

ENSG00000057593

Encoded Proteins

IDBP-52194

coagulation factor VII (serum prothrombin conversion accelerator)

IDBP-52196

coagulation factor VII (serum prothrombin conversion accelerator)

IDBP-374149

coagulation factor VII (serum prothrombin conversion accelerator)

IDBP-585494

coagulation factor VII (serum prothrombin conversion accelerator)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes coagulation factor VII which is a vitamin K-dependent factor essential for hemostasis. This factor circulates in the blood in a zymogen form, and is converted to an active form by either factor IXa, factor Xa, factor XIIa, or thrombin by minor proteolysis. Upon activation of the factor VII, a heavy chain containing a catalytic domain and a light chain containing 2 EGF-like domains are generated, and two chains are held together by a disulfide bond. In the presence of factor III and calcium ions, the activated factor then further activates the coagulation cascade by converting factor IX to factor IXa and/or factor X to factor Xa. Defects in this gene can cause coagulopathy. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, May 2012]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 13:113105788-113120681

Strand

Forward strand

Band

q34

Transcripts

ENST00000346342	ENSP00000329546
ENST00000375581	ENSP00000364731
ENST00000444337	ENSP00000387669
ENST00000479674
ENST00000473085
ENST00000541084	ENSP00000442051

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.

Experimentally validated
Total	15 [view]
Protein-Protein	14 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001948	glycoprotein binding
GO:0003824	catalytic activity
GO:0004175	endopeptidase activity
GO:0004252	serine-type endopeptidase activity
GO:0005102	receptor binding
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0008236	serine-type peptidase activity

Biological Process

GO:0002690	positive regulation of leukocyte chemotaxis
GO:0006508	proteolysis
GO:0007596	blood coagulation
GO:0007598	blood coagulation, extrinsic pathway
GO:0007623	circadian rhythm
GO:0009725	response to hormone
GO:0010641	positive regulation of platelet-derived growth factor receptor signaling pathway
GO:0014070	response to organic cyclic compound
GO:0017187	peptidyl-glutamic acid carboxylation
GO:0030194	positive regulation of blood coagulation
GO:0030335	positive regulation of cell migration
GO:0031100	organ regeneration
GO:0031667	response to nutrient levels
GO:0032571	response to vitamin K
GO:0043627	response to estrogen
GO:0043687	post-translational protein modification
GO:0044267	cellular protein metabolic process
GO:0050927	positive regulation of positive chemotaxis
GO:0051897	positive regulation of protein kinase B signaling
GO:0060416	response to growth hormone

Cellular Component

GO:0005576	extracellular region
GO:0005615	extracellular space
GO:0005788	endoplasmic reticulum lumen
GO:0005796	Golgi lumen
GO:0005886	plasma membrane
GO:0031982	vesicle