Homo sapiens Gene: F10
Summary
InnateDB Gene IDBG-52275.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol F10
Gene Name coagulation factor X
Synonyms FX; FXA;
Species Homo sapiens
Ensembl Gene ENSG00000126218
Encoded Proteins
coagulation factor X
coagulation factor X
coagulation factor X
coagulation factor X
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes the vitamin K-dependent coagulation factor X of the blood coagulation cascade. This factor undergoes multiple processing steps before its preproprotein is converted to a mature two-chain form by the excision of the tripeptide RKR. Two chains of the factor are held together by 1 or more disulfide bonds; the light chain contains 2 EGF-like domains, while the heavy chain contains the catalytic domain which is structurally homologous to those of the other hemostatic serine proteases. The mature factor is activated by the cleavage of the activation peptide by factor IXa (in the intrisic pathway), or by factor VIIa (in the extrinsic pathway). The activated factor then converts prothrombin to thrombin in the presence of factor Va, Ca+2, and phospholipid during blood clotting. Mutations of this gene result in factor X deficiency, a hemorrhagic condition of variable severity. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 13:113122814-113149529
Strand Forward strand
Band q34
Transcripts
ENST00000375559 ENSP00000364709
ENST00000375551 ENSP00000364701
ENST00000409306 ENSP00000387092
ENST00000410083 ENSP00000386320
ENST00000477269
ENST00000483537
ENST00000498455
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 16 experimentally validated interaction(s) in this database.
Experimentally validated
Total 16 [view]
Protein-Protein 15 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0004252 serine-type endopeptidase activity
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0005543 phospholipid binding
Biological Process
GO:0006508 proteolysis
GO:0007596 blood coagulation
GO:0007597 blood coagulation, intrinsic pathway
GO:0007598 blood coagulation, extrinsic pathway
GO:0017187 peptidyl-glutamic acid carboxylation
GO:0030335 positive regulation of cell migration
GO:0043687 post-translational protein modification
GO:0044267 cellular protein metabolic process
GO:0051897 positive regulation of protein kinase B signaling
Cellular Component
GO:0005576 extracellular region
GO:0005788 endoplasmic reticulum lumen
GO:0005796 Golgi lumen
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0031233 intrinsic to external side of plasma membrane
GO:0043231 intracellular membrane-bounded organelle
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Not yet available
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Pathways
NETPATH
REACTOME
Post-translational protein modification pathway
Gamma-carboxylation, transport, and amino-terminal cleavage of proteins pathway
Formation of Fibrin Clot (Clotting Cascade) pathway
PTM: gamma carboxylation, hypusine formation and arylsulfatase activation pathway
Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus pathway
Metabolism of proteins pathway
Intrinsic Pathway pathway
Common Pathway pathway
Extrinsic Pathway pathway
Removal of aminoterminal propeptides from gamma-carboxylated proteins pathway
Gamma-carboxylation of protein precursors pathway
Hemostasis pathway
KEGG
Complement and coagulation cascades pathway
INOH
PID BIOCARTA
Extrinsic prothrombin activation pathway [Biocarta view]
Intrinsic prothrombin activation pathway [Biocarta view]
PID NCI
Beta2 integrin cell surface interactions
Cross-References
SwissProt
TrEMBL Q5JVE8
UniProt Splice Variant
Entrez Gene 2159
UniGene Hs.361463 Hs.702204
RefSeq XM_005268298 NM_000504
HUGO HGNC:3528
OMIM 613872
CCDS CCDS9530
HPRD 01966
IMGT
EMBL AL137002
GenPept
RNA Seq Atlas 2159