InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: F10

Summary

InnateDB Gene

IDBG-52275.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

F10

Gene Name

coagulation factor X

Synonyms

FX; FXA

Species

Homo sapiens

Ensembl Gene

ENSG00000126218

Encoded Proteins

IDBP-52277

coagulation factor X

IDBP-52279

coagulation factor X

IDBP-293459

coagulation factor X

IDBP-293456

coagulation factor X

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes the vitamin K-dependent coagulation factor X of the blood coagulation cascade. This factor undergoes multiple processing steps before its preproprotein is converted to a mature two-chain form by the excision of the tripeptide RKR. Two chains of the factor are held together by 1 or more disulfide bonds; the light chain contains 2 EGF-like domains, while the heavy chain contains the catalytic domain which is structurally homologous to those of the other hemostatic serine proteases. The mature factor is activated by the cleavage of the activation peptide by factor IXa (in the intrisic pathway), or by factor VIIa (in the extrinsic pathway). The activated factor then converts prothrombin to thrombin in the presence of factor Va, Ca+2, and phospholipid during blood clotting. Mutations of this gene result in factor X deficiency, a hemorrhagic condition of variable severity. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 13:113122814-113149529

Strand

Forward strand

Band

q34

Transcripts

ENST00000375559	ENSP00000364709
ENST00000375551	ENSP00000364701
ENST00000409306	ENSP00000387092
ENST00000410083	ENSP00000386320
ENST00000477269
ENST00000483537
ENST00000498455

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 16 experimentally validated interaction(s) in this database.

Experimentally validated
Total	16 [view]
Protein-Protein	15 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0004252	serine-type endopeptidase activity
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0005543	phospholipid binding

Biological Process

GO:0006508	proteolysis
GO:0007596	blood coagulation
GO:0007597	blood coagulation, intrinsic pathway
GO:0007598	blood coagulation, extrinsic pathway
GO:0017187	peptidyl-glutamic acid carboxylation
GO:0030335	positive regulation of cell migration
GO:0043687	post-translational protein modification
GO:0044267	cellular protein metabolic process
GO:0051897	positive regulation of protein kinase B signaling

Cellular Component

GO:0005576	extracellular region
GO:0005788	endoplasmic reticulum lumen
GO:0005796	Golgi lumen
GO:0005886	plasma membrane
GO:0016020	membrane
GO:0031233	intrinsic to external side of plasma membrane
GO:0043231	intracellular membrane-bounded organelle