Homo sapiens Gene: CD86
Summary
InnateDB Gene IDBG-52336.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CD86
Gene Name CD86 molecule
Synonyms B7-2; B7.2; B70; CD28LG2; LAB72;
Species Homo sapiens
Ensembl Gene ENSG00000114013
Encoded Proteins
CD86 molecule
CD86 molecule
CD86 molecule
CD86 molecule
CD86 molecule
CD86 molecule
CD86 molecule
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation from Orthologs
Summary
[Mus musculus] Tmem126a upregulates genes involved in antigen presentation; such as Icam1, MHC II, Cd86 and Cd40, via the Tlr4 signal transduction pathway.
Entrez Gene
Summary This gene encodes a type I membrane protein that is a member of the immunoglobulin superfamily. This protein is expressed by antigen-presenting cells, and it is the ligand for two proteins at the cell surface of T cells, CD28 antigen and cytotoxic T-lymphocyte-associated protein 4. Binding of this protein with CD28 antigen is a costimulatory signal for activation of the T-cell. Binding of this protein with cytotoxic T-lymphocyte-associated protein 4 negatively regulates T-cell activation and diminishes the immune response. Alternative splicing results in several transcript variants encoding different isoforms.[provided by RefSeq, May 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:122055366-122121139
Strand Forward strand
Band q13.33
Transcripts
ENST00000330540 ENSP00000332049
ENST00000264468 ENSP00000264468
ENST00000393627 ENSP00000377248
ENST00000469710 ENSP00000418988
ENST00000493101 ENSP00000420230
ENST00000478390
ENST00000483949
ENST00000482356 ENSP00000419116
ENST00000478741 ENSP00000417195
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 10 [view]
Protein-Protein 10 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004872 receptor activity
GO:0005102 receptor binding
GO:0005515 protein binding
GO:0015026 coreceptor activity
Biological Process
GO:0001878 response to yeast
GO:0002224 toll-like receptor signaling pathway
GO:0002309 T cell proliferation involved in immune response
GO:0002668 negative regulation of T cell anergy
GO:0006955 immune response
GO:0007173 epidermal growth factor receptor signaling pathway
GO:0007267 cell-cell signaling
GO:0007568 aging
GO:0008284 positive regulation of cell proliferation
GO:0008543 fibroblast growth factor receptor signaling pathway
GO:0016032 viral process
GO:0031295 T cell costimulation
GO:0032496 response to lipopolysaccharide
GO:0034341 response to interferon-gamma
GO:0038095 Fc-epsilon receptor signaling pathway
GO:0042102 positive regulation of T cell proliferation
GO:0042104 positive regulation of activated T cell proliferation
GO:0042110 T cell activation
GO:0042113 B cell activation
GO:0042493 response to drug
GO:0043011 myeloid dendritic cell differentiation
GO:0043017 positive regulation of lymphotoxin A biosynthetic process
GO:0045086 positive regulation of interleukin-2 biosynthetic process
GO:0045087 innate immune response
GO:0045404 positive regulation of interleukin-4 biosynthetic process
GO:0045630 positive regulation of T-helper 2 cell differentiation
GO:0045893 positive regulation of transcription, DNA-templated
GO:0048011 neurotrophin TRK receptor signaling pathway
GO:0048015 phosphatidylinositol-mediated signaling
GO:0051607 defense response to virus
GO:0071222 cellular response to lipopolysaccharide
GO:0071248 cellular response to metal ion
GO:0071345 cellular response to cytokine stimulus
Cellular Component
GO:0005886 plasma membrane
GO:0009897 external side of plasma membrane
GO:0009986 cell surface
GO:0016021 integral component of membrane
GO:0043231 intracellular membrane-bounded organelle
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Gene ID
Gene Order
Method
Confidence
Comments
Low
Tentative data, uncurated. RBBH derived.
Pathways
NETPATH
TCR pathway
REACTOME
Signaling by FGFR in disease pathway
Signalling by NGF pathway
Signaling by EGFR in Cancer pathway
PI3K/AKT activation pathway
Downstream signaling of activated FGFR pathway
PI-3K cascade pathway
PI3K events in ERBB2 signaling pathway
DAP12 signaling pathway
Signaling by EGFR pathway
Role of LAT2/NTAL/LAB on calcium mobilization pathway
Constitutive PI3K/AKT Signaling in Cancer pathway
Innate Immune System pathway
Signaling by ERBB4 pathway
Signaling by SCF-KIT pathway
Fc epsilon receptor (FCERI) signaling pathway
Signal Transduction pathway
CD28 co-stimulation pathway
CD28 dependent Vav1 pathway pathway
Adaptive Immune System pathway
Immune System pathway
Downstream signal transduction pathway
NGF signalling via TRKA from the plasma membrane pathway
PI3K/AKT Signaling in Cancer pathway
Signaling by FGFR pathway
CD28 dependent PI3K/Akt signaling pathway
PIP3 activates AKT signaling pathway
Signaling by PDGF pathway
Signaling by ERBB2 pathway
Costimulation by the CD28 family pathway
Signaling by the B Cell Receptor (BCR) pathway
GAB1 signalosome pathway
CTLA4 inhibitory signaling pathway
Downstream signaling events of B Cell Receptor (BCR) pathway
Disease pathway
PI3K events in ERBB4 signaling pathway
DAP12 interactions pathway
KEGG
Cell adhesion molecules (CAMs) pathway
Toll-like receptor signaling pathway pathway
Intestinal immune network for IgA production pathway
Type I diabetes mellitus pathway
Autoimmune thyroid disease pathway
Systemic lupus erythematosus pathway
Allograft rejection pathway
Graft-versus-host disease pathway
Viral myocarditis pathway
INOH
GPCR signaling pathway
CD4 T cell receptor signaling pathway
PID BIOCARTA
The co-stimulatory signal during t-cell activation [Biocarta view]
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.171182 Hs.601198
RefSeq NM_001206924 NM_001206925 NM_006889 NM_175862 NM_176892 XM_005247905
HUGO
OMIM
CCDS CCDS3009 CCDS43138 CCDS56272 CCDS56273 CCDS74991
HPRD 03011
IMGT
EMBL
GenPept
RNA Seq Atlas