Version 5.4
| Homo sapiens Gene: PROZ | |||||||||||||||||||
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| Summary | |||||||||||||||||||
| InnateDB Gene | IDBG-52386.5 | ||||||||||||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||
| Gene Symbol | PROZ | ||||||||||||||||||
| Gene Name | protein Z, vitamin K-dependent plasma glycoprotein | ||||||||||||||||||
| Synonyms | PZ; | ||||||||||||||||||
| Species | Homo sapiens | ||||||||||||||||||
| Ensembl Gene | ENSG00000126231 | ||||||||||||||||||
| Encoded Proteins |
protein Z, vitamin K-dependent plasma glycoprotein
protein Z, vitamin K-dependent plasma glycoprotein
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| Protein Structure |
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| Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||
| Entrez Gene | |||||||||||||||||||
| Summary |
This gene encodes a liver vitamin K-dependent glycoprotein that is synthesized in the liver and secreted into the plasma. The encoded protein plays a role in regulating blood coagulation by complexing with protein Z-dependent protease inhibitor to directly inhibit activated factor X at the phospholipid surface. Deficiencies in this protein are associated with an increased risk of ischemic arterial diseases and fetal loss. Mutations in this gene are the cause of protein Z deficiency. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2012] |
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| Gene Information | |||||||||||||||||||
| Type | Protein coding | ||||||||||||||||||
| Genomic Location | Chromosome 13:113158654-113172383 | ||||||||||||||||||
| Strand | Forward strand | ||||||||||||||||||
| Band | q34 | ||||||||||||||||||
| Transcripts |
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| Interactions | |||||||||||||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
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| Gene Ontology | |||||||||||||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||||||||||||||
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Species
Mus musculus
Bos taurus
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Gene ID
Gene Order
Method
Confidence
Comments
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Not yet available
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
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| Pathways | |||||||||||||||||||
| NETPATH | |||||||||||||||||||
| REACTOME |
Post-translational protein modification pathway
Gamma-carboxylation, transport, and amino-terminal cleavage of proteins pathway
PTM: gamma carboxylation, hypusine formation and arylsulfatase activation pathway
Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus pathway
Metabolism of proteins pathway
Removal of aminoterminal propeptides from gamma-carboxylated proteins pathway
Gamma-carboxylation of protein precursors pathway
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| KEGG | |||||||||||||||||||
| INOH | |||||||||||||||||||
| PID BIOCARTA | |||||||||||||||||||
| PID NCI | |||||||||||||||||||
| Cross-References | |||||||||||||||||||
| SwissProt | P22891 | ||||||||||||||||||
| TrEMBL | B0YJC6 | ||||||||||||||||||
| UniProt Splice Variant | |||||||||||||||||||
| Entrez Gene | 8858 | ||||||||||||||||||
| UniGene | Hs.1011 | ||||||||||||||||||
| RefSeq | NM_001256134 NM_003891 | ||||||||||||||||||
| HUGO | HGNC:9460 | ||||||||||||||||||
| OMIM | 176895 | ||||||||||||||||||
| CCDS | CCDS58300 CCDS9531 | ||||||||||||||||||
| HPRD | 07182 | ||||||||||||||||||
| IMGT | |||||||||||||||||||
| EMBL | AB033749 AF440358 AL137002 BC074906 BC074907 CH471085 EF445049 M55670 M55671 M59303 | ||||||||||||||||||
| GenPept | AAA36499 AAA36500 AAA36501 AAH74906 AAH74907 AAL27631 ACA06105 ACA06106 BAA85763 BAA85764 CAI41388 CAI41389 EAX09186 EAX09187 | ||||||||||||||||||
| RNA Seq Atlas | 8858 | ||||||||||||||||||