Homo sapiens Gene: PROZ | |||||||||||||||||||
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Summary | |||||||||||||||||||
InnateDB Gene | IDBG-52386.5 | ||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||
Gene Symbol | PROZ | ||||||||||||||||||
Gene Name | protein Z, vitamin K-dependent plasma glycoprotein | ||||||||||||||||||
Synonyms | PZ | ||||||||||||||||||
Species | Homo sapiens | ||||||||||||||||||
Ensembl Gene | ENSG00000126231 | ||||||||||||||||||
Encoded Proteins |
protein Z, vitamin K-dependent plasma glycoprotein
protein Z, vitamin K-dependent plasma glycoprotein
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Protein Structure | |||||||||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||
Entrez Gene | |||||||||||||||||||
Summary |
This gene encodes a liver vitamin K-dependent glycoprotein that is synthesized in the liver and secreted into the plasma. The encoded protein plays a role in regulating blood coagulation by complexing with protein Z-dependent protease inhibitor to directly inhibit activated factor X at the phospholipid surface. Deficiencies in this protein are associated with an increased risk of ischemic arterial diseases and fetal loss. Mutations in this gene are the cause of protein Z deficiency. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2012] |
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Gene Information | |||||||||||||||||||
Type | Protein coding | ||||||||||||||||||
Genomic Location | Chromosome 13:113158654-113172383 | ||||||||||||||||||
Strand | Forward strand | ||||||||||||||||||
Band | q34 | ||||||||||||||||||
Transcripts |
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Interactions | |||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
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Gene Ontology | |||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||||||||||||
Species
Mus musculus
Bos taurus
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Gene ID
Gene Order
Not yet available
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Pathways | |||||||||||||||||||
NETPATH | |||||||||||||||||||
REACTOME |
Gamma-carboxylation of protein precursors pathway
Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus pathway
Removal of aminoterminal propeptides from gamma-carboxylated proteins pathway
Gamma-carboxylation, transport, and amino-terminal cleavage of proteins pathway
Post-translational protein modification pathway
PTM: gamma carboxylation, hypusine formation and arylsulfatase activation pathway
Metabolism of proteins pathway
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KEGG | |||||||||||||||||||
INOH | |||||||||||||||||||
PID NCI | |||||||||||||||||||
Cross-References | |||||||||||||||||||
SwissProt | P22891 | ||||||||||||||||||
TrEMBL | B0YJC6 | ||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||
Entrez Gene | 8858 | ||||||||||||||||||
UniGene | Hs.1011 | ||||||||||||||||||
RefSeq | NM_001256134 NM_003891 | ||||||||||||||||||
HUGO | HGNC:9460 | ||||||||||||||||||
OMIM | 176895 | ||||||||||||||||||
CCDS | CCDS58300 CCDS9531 | ||||||||||||||||||
HPRD | |||||||||||||||||||
IMGT | |||||||||||||||||||
EMBL | AB033749 AF440358 AL137002 BC074906 BC074907 CH471085 EF445049 M55670 M55671 M59303 | ||||||||||||||||||
GenPept | AAA36499 AAA36500 AAA36501 AAH74906 AAH74907 AAL27631 ACA06105 ACA06106 BAA85763 BAA85764 CAI41388 CAI41389 EAX09186 EAX09187 | ||||||||||||||||||
RNA Seq Atlas | 8858 | ||||||||||||||||||