Homo sapiens Gene: PROZ
Summary
InnateDB Gene IDBG-52386.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PROZ
Gene Name protein Z, vitamin K-dependent plasma glycoprotein
Synonyms PZ;
Species Homo sapiens
Ensembl Gene ENSG00000126231
Encoded Proteins
protein Z, vitamin K-dependent plasma glycoprotein
protein Z, vitamin K-dependent plasma glycoprotein
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a liver vitamin K-dependent glycoprotein that is synthesized in the liver and secreted into the plasma. The encoded protein plays a role in regulating blood coagulation by complexing with protein Z-dependent protease inhibitor to directly inhibit activated factor X at the phospholipid surface. Deficiencies in this protein are associated with an increased risk of ischemic arterial diseases and fetal loss. Mutations in this gene are the cause of protein Z deficiency. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 13:113158654-113172383
Strand Forward strand
Band q34
Transcripts
ENST00000375547 ENSP00000364697
ENST00000342783 ENSP00000344458
ENST00000493630
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 0
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0004252 serine-type endopeptidase activity
GO:0005509 calcium ion binding
GO:0005515 protein binding
Biological Process
GO:0006508 proteolysis
GO:0007596 blood coagulation
GO:0017187 peptidyl-glutamic acid carboxylation
GO:0043687 post-translational protein modification
GO:0044267 cellular protein metabolic process
Cellular Component
GO:0005576 extracellular region
GO:0005788 endoplasmic reticulum lumen
GO:0005796 Golgi lumen
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Not yet available
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Pathways
NETPATH
REACTOME
Post-translational protein modification pathway
Gamma-carboxylation, transport, and amino-terminal cleavage of proteins pathway
PTM: gamma carboxylation, hypusine formation and arylsulfatase activation pathway
Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus pathway
Metabolism of proteins pathway
Removal of aminoterminal propeptides from gamma-carboxylated proteins pathway
Gamma-carboxylation of protein precursors pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt P22891
TrEMBL B0YJC6
UniProt Splice Variant
Entrez Gene 8858
UniGene Hs.1011
RefSeq NM_001256134 NM_003891
HUGO HGNC:9460
OMIM 176895
CCDS CCDS58300 CCDS9531
HPRD 07182
IMGT
EMBL AB033749 AF440358 AL137002 BC074906 BC074907 CH471085 EF445049 M55670 M55671 M59303
GenPept AAA36499 AAA36500 AAA36501 AAH74906 AAH74907 AAL27631 ACA06105 ACA06106 BAA85763 BAA85764 CAI41388 CAI41389 EAX09186 EAX09187
RNA Seq Atlas 8858