Version 5.4
Mus musculus Gene: Proz
Summary
InnateDB Gene IDBG-134381.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Proz
Gene Name protein Z, vitamin K-dependent plasma glycoprotein
Synonyms 1300015B06Rik
Species Mus musculus
Ensembl Gene ENSMUSG00000031445
Encoded Proteins
IDBP-134383
protein Z, vitamin K-dependent plasma glycoprotein
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000126231:
This gene encodes a liver vitamin K-dependent glycoprotein that is synthesized in the liver and secreted into the plasma. The encoded protein plays a role in regulating blood coagulation by complexing with protein Z-dependent protease inhibitor to directly inhibit activated factor X at the phospholipid surface. Deficiencies in this protein are associated with an increased risk of ischemic arterial diseases and fetal loss. Mutations in this gene are the cause of protein Z deficiency. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:13060908-13075006
Strand Forward strand
Band A1.1
Transcripts
ENSMUST00000033822 ENSMUSP00000033822
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0004252 serine-type endopeptidase activity
GO:0005509 calcium ion binding
GO:0005515 protein binding
Biological Process
GO:0006508 proteolysis
GO:0007596 blood coagulation
Cellular Component
GO:0005576 extracellular region
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000126231
View Gene Order
ENSBTAG00000019440
Not yet available
Pathways
NETPATH
REACTOME
REACT_245393
Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus pathway
REACT_247926
Metabolism of proteins pathway
REACT_236283
Post-translational protein modification pathway
REACT_235159
Gamma-carboxylation, transport, and amino-terminal cleavage of proteins pathway
REACT_254191
Gamma-carboxylation of protein precursors pathway
REACT_229541
PTM: gamma carboxylation, hypusine formation and arylsulfatase activation pathway
REACT_255710
Removal of aminoterminal propeptides from gamma-carboxylated proteins pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_1050
Gamma-carboxylation of protein precursors pathway
REACT_1906
Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus pathway
REACT_733
Removal of aminoterminal propeptides from gamma-carboxylated proteins pathway
REACT_1132
Gamma-carboxylation, transport, and amino-terminal cleavage of proteins pathway
REACT_22161
Post-translational protein modification pathway
REACT_1069
PTM: gamma carboxylation, hypusine formation and arylsulfatase activation pathway
REACT_17015
Metabolism of proteins pathway
REACT_212120
Gamma-carboxylation of protein precursors pathway
REACT_216886
Removal of aminoterminal propeptides from gamma-carboxylated proteins pathway
REACT_216819
Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus pathway
REACT_213782
Metabolism of proteins pathway
REACT_214405
Post-translational protein modification pathway
REACT_201970
Gamma-carboxylation, transport, and amino-terminal cleavage of proteins pathway
REACT_206715
PTM: gamma carboxylation, hypusine formation and arylsulfatase activation pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.441140
RefSeq NM_025834
OMIM
CCDS CCDS22105
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca