Homo sapiens Gene: MTIF2
Summary
InnateDB Gene IDBG-52399.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MTIF2
Gene Name mitochondrial translational initiation factor 2
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000085760
Encoded Proteins
mitochondrial translational initiation factor 2
mitochondrial translational initiation factor 2
mitochondrial translational initiation factor 2
mitochondrial translational initiation factor 2
mitochondrial translational initiation factor 2
mitochondrial translational initiation factor 2
mitochondrial translational initiation factor 2
mitochondrial translational initiation factor 2
mitochondrial translational initiation factor 2
mitochondrial translational initiation factor 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary During the initiation of protein biosynthesis, initiation factor-2 (IF-2) promotes the binding of the initiator tRNA to the small subunit of the ribosome in a GTP-dependent manner. Prokaryotic IF-2 is a single polypeptide, while eukaryotic cytoplasmic IF-2 (eIF-2) is a trimeric protein. Bovine liver mitochondria contain IF-2(mt), an 85-kD monomeric protein that is equivalent to prokaryotic IF-2. The predicted 727-amino acid human protein contains a 29-amino acid presequence. Human IF-2(mt) shares 32 to 38% amino acid sequence identity with yeast IF-2(mt) and several prokaryotic IF-2s, with the greatest degree of conservation in the G domains of the proteins. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
During the initiation of protein biosynthesis, initiation factor-2 (IF-2) promotes the binding of the initiator tRNA to the small subunit of the ribosome in a GTP-dependent manner. Prokaryotic IF-2 is a single polypeptide, while eukaryotic cytoplasmic IF-2 (eIF-2) is a trimeric protein. Bovine liver mitochondria contain IF-2(mt), an 85-kD monomeric protein that is equivalent to prokaryotic IF-2. The predicted 727-amino acid human protein contains a 29-amino acid presequence. Human IF-2(mt) shares 32 to 38%% amino acid sequence identity with yeast IF-2(mt) and several prokaryotic IF-2s, with the greatest degree of conservation in the G domains of the proteins. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:55236595-55269347
Strand Reverse strand
Band p16.1
Transcripts
ENST00000263629 ENSP00000263629
ENST00000366137 ENSP00000393337
ENST00000394600 ENSP00000378099
ENST00000403721 ENSP00000384481
ENST00000404297 ENSP00000383880
ENST00000418823 ENSP00000403492
ENST00000417741
ENST00000446660
ENST00000441307 ENSP00000388640
ENST00000420637 ENSP00000416057
ENST00000417363 ENSP00000399531
ENST00000412530 ENSP00000393025
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
Experimentally validated
Total 5 [view]
Protein-Protein 5 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003743 translation initiation factor activity
GO:0003924 GTPase activity
GO:0005525 GTP binding
GO:0008135 translation factor activity, nucleic acid binding
GO:0043024 ribosomal small subunit binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0001732 formation of translation initiation complex
GO:0006184 GTP catabolic process
GO:0006446 regulation of translational initiation
GO:0007264 small GTPase mediated signal transduction
GO:0032790 ribosome disassembly
Cellular Component
GO:0005622 intracellular
GO:0005739 mitochondrion
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
TNFalpha pathway
REACTOME
Organelle biogenesis and maintenance pathway
Mitochondrial translation pathway
Mitochondrial translation initiation pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL B5MCU1 C9JIY5
UniProt Splice Variant
Entrez Gene 4528
UniGene Hs.149894
RefSeq NM_002453 NM_001005369 XM_006712023 XM_005264335
HUGO HGNC:7441
OMIM 603766
CCDS CCDS1853
HPRD 04792
IMGT
EMBL AC012358
GenPept
RNA Seq Atlas 4528