Version 5.4
Homo sapiens Gene: MTIF2
Summary
InnateDB Gene IDBG-52399.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MTIF2
Gene Name mitochondrial translational initiation factor 2
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000085760
Encoded Proteins
IDBP-52401
mitochondrial translational initiation factor 2
IDBP-376252
mitochondrial translational initiation factor 2
IDBP-241248
mitochondrial translational initiation factor 2
IDBP-293292
mitochondrial translational initiation factor 2
IDBP-293288
mitochondrial translational initiation factor 2
IDBP-376244
mitochondrial translational initiation factor 2
IDBP-376254
mitochondrial translational initiation factor 2
IDBP-376257
mitochondrial translational initiation factor 2
IDBP-376259
mitochondrial translational initiation factor 2
IDBP-376260
mitochondrial translational initiation factor 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary During the initiation of protein biosynthesis, initiation factor-2 (IF-2) promotes the binding of the initiator tRNA to the small subunit of the ribosome in a GTP-dependent manner. Prokaryotic IF-2 is a single polypeptide, while eukaryotic cytoplasmic IF-2 (eIF-2) is a trimeric protein. Bovine liver mitochondria contain IF-2(mt), an 85-kD monomeric protein that is equivalent to prokaryotic IF-2. The predicted 727-amino acid human protein contains a 29-amino acid presequence. Human IF-2(mt) shares 32 to 38% amino acid sequence identity with yeast IF-2(mt) and several prokaryotic IF-2s, with the greatest degree of conservation in the G domains of the proteins. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
During the initiation of protein biosynthesis, initiation factor-2 (IF-2) promotes the binding of the initiator tRNA to the small subunit of the ribosome in a GTP-dependent manner. Prokaryotic IF-2 is a single polypeptide, while eukaryotic cytoplasmic IF-2 (eIF-2) is a trimeric protein. Bovine liver mitochondria contain IF-2(mt), an 85-kD monomeric protein that is equivalent to prokaryotic IF-2. The predicted 727-amino acid human protein contains a 29-amino acid presequence. Human IF-2(mt) shares 32 to 38%% amino acid sequence identity with yeast IF-2(mt) and several prokaryotic IF-2s, with the greatest degree of conservation in the G domains of the proteins. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:55236595-55269347
Strand Reverse strand
Band p16.1
Transcripts
ENST00000263629 ENSP00000263629
ENST00000366137 ENSP00000393337
ENST00000394600 ENSP00000378099
ENST00000403721 ENSP00000384481
ENST00000404297 ENSP00000383880
ENST00000418823 ENSP00000403492
ENST00000417741
ENST00000446660
ENST00000441307 ENSP00000388640
ENST00000420637 ENSP00000416057
ENST00000417363 ENSP00000399531
ENST00000412530 ENSP00000393025
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
Experimentally validated
Total 5 [view]
Protein-Protein 5 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003743 translation initiation factor activity
GO:0003924 GTPase activity
GO:0005525 GTP binding
GO:0008135 translation factor activity, nucleic acid binding
GO:0043024 ribosomal small subunit binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0001732 formation of translation initiation complex
GO:0006184 GTP catabolic process
GO:0006446 regulation of translational initiation
GO:0007264 small GTPase mediated signal transduction
GO:0032790 ribosome disassembly
Cellular Component
GO:0005622 intracellular
GO:0005739 mitochondrion
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000020459
View Gene Order
ENSBTAG00000015481
Not yet available
Pathways
NETPATH
NetPath_9
TNFalpha pathway
REACTOME
REACT_200751
Organelle biogenesis and maintenance pathway
REACT_267673
Mitochondrial translation pathway
REACT_267680
Mitochondrial translation initiation pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.149894
RefSeq NM_001005369 NM_002453 XM_005264335 XM_006712023
HUGO
OMIM
CCDS CCDS1853
HPRD 04792
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca