InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: CYP2B6

Summary

InnateDB Gene

IDBG-52438.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CYP2B6

Gene Name

cytochrome P450, family 2, subfamily B, polypeptide 6

Synonyms

CPB6; CYP2B; CYP2B7; CYP2B7P; CYPIIB6; EFVM; IIB1; P450

Species

Homo sapiens

Ensembl Gene

ENSG00000197408

Encoded Proteins

IDBP-52440

cytochrome P450, family 2, subfamily B, polypeptide 6

IDBP-765205

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene, CYP2B6, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by phenobarbital. The enzyme is known to metabolize some xenobiotics, such as the anti-cancer drugs cyclophosphamide and ifosphamide. Transcript variants for this gene have been described; however, it has not been resolved whether these transcripts are in fact produced by this gene or by a closely related pseudogene, CYP2B7. Both the gene and the pseudogene are located in the middle of a CYP2A pseudogene found in a large cluster of cytochrome P450 genes from the CYP2A, CYP2B and CYP2F subfamilies on chromosome 19q. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 19:40991299-41018398

Strand

Forward strand

Band

q13.2

Transcripts

ENST00000324071	ENSP00000324648
ENST00000598834
ENST00000594187
ENST00000593831	ENSP00000470582
ENST00000597612

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	0
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004497	monooxygenase activity
GO:0005506	iron ion binding
GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
GO:0016712	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
GO:0020037	heme binding

Biological Process

GO:0006805	xenobiotic metabolic process
GO:0008202	steroid metabolic process
GO:0017144	drug metabolic process
GO:0042180	cellular ketone metabolic process
GO:0042738	exogenous drug catabolic process
GO:0044281	small molecule metabolic process
GO:0055114	oxidation-reduction process

Cellular Component

GO:0005789

endoplasmic reticulum membrane

Orthologs

No orthologs found for this gene

Pathways

NETPATH

REACTOME

REACT_13814

Fatty acids pathway

REACT_13797

CYP2E1 reactions pathway

REACT_13543

Xenobiotics pathway

REACT_13567

Cytochrome P450 - arranged by substrate type pathway

REACT_111217

Metabolism pathway

REACT_13433

Biological oxidations pathway

REACT_13705

Phase 1 - Functionalization of compounds pathway

KEGG

hsa00590

Arachidonic acid metabolism pathway

hsa00830

Retinol metabolism pathway

hsa00980

Metabolism of xenobiotics by cytochrome P450 pathway

hsa00982

Drug metabolism pathway

INOH

INOH website

Tryptophan degradation pathway

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.1360

RefSeq

NM_000767 XM_006723051

HUGO

OMIM

CCDS

CCDS12570

HPRD

00477

IMGT

EMBL

GenPept

RNA Seq Atlas