Homo sapiens Gene: CYP2B6
Summary
InnateDB Gene IDBG-52438.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CYP2B6
Gene Name cytochrome P450, family 2, subfamily B, polypeptide 6
Synonyms CPB6; CYP2B; CYP2B7; CYP2B7P; CYPIIB6; EFVM; IIB1; P450;
Species Homo sapiens
Ensembl Gene ENSG00000197408
Encoded Proteins
cytochrome P450, family 2, subfamily B, polypeptide 6
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene, CYP2B6, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by phenobarbital. The enzyme is known to metabolize some xenobiotics, such as the anti-cancer drugs cyclophosphamide and ifosphamide. Transcript variants for this gene have been described; however, it has not been resolved whether these transcripts are in fact produced by this gene or by a closely related pseudogene, CYP2B7. Both the gene and the pseudogene are located in the middle of a CYP2A pseudogene found in a large cluster of cytochrome P450 genes from the CYP2A, CYP2B and CYP2F subfamilies on chromosome 19q. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:40991299-41018398
Strand Forward strand
Band q13.2
Transcripts
ENST00000324071 ENSP00000324648
ENST00000598834
ENST00000594187
ENST00000593831 ENSP00000470582
ENST00000597612
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 0
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004497 monooxygenase activity
GO:0005506 iron ion binding
GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
GO:0020037 heme binding
Biological Process
GO:0006805 xenobiotic metabolic process
GO:0008202 steroid metabolic process
GO:0017144 drug metabolic process
GO:0042180 cellular ketone metabolic process
GO:0042738 exogenous drug catabolic process
GO:0044281 small molecule metabolic process
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005789 endoplasmic reticulum membrane
Orthologs
No orthologs found for this gene
Pathways
NETPATH
REACTOME
CYP2E1 reactions pathway
Cytochrome P450 - arranged by substrate type pathway
Fatty acids pathway
Xenobiotics pathway
Metabolism pathway
Biological oxidations pathway
Phase 1 - Functionalization of compounds pathway
KEGG
Arachidonic acid metabolism pathway
Retinol metabolism pathway
Metabolism of xenobiotics by cytochrome P450 pathway
Drug metabolism pathway
INOH
Tryptophan degradation pathway
PID BIOCARTA
PID NCI
Cross-References
SwissProt P20813
TrEMBL F2X1B0 Q9UNX8
UniProt Splice Variant
Entrez Gene 1555
UniGene Hs.1360
RefSeq NM_000767 XM_006723051
HUGO HGNC:2615
OMIM 123930
CCDS CCDS12570
HPRD 00477
IMGT
EMBL AC023172 AF081569 AF182277 DQ298753 HQ291562 HQ291563 HQ291564 HQ291565 HQ291566 M29874 X13494
GenPept AAA52144 AAD25924 AAF13602 AAF32444 ABB84469 AEA03271 AEA03272 AEA03273 AEA03274 AEA03275
RNA Seq Atlas 1555