InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CYP2B6

Summary

InnateDB Protein

IDBP-52440.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CYP2B6

Protein Name

cytochrome P450, family 2, subfamily B, polypeptide 6

Synonyms

CPB6; CYP2B; CYP2B7; CYP2B7P; CYPIIB6; EFVM; IIB1; P450;

Species

Homo sapiens

Ensembl Protein

ENSP00000324648

InnateDB Gene

IDBG-52438 (CYP2B6)

Protein Structure

UniProt Annotation

Function

Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Acts as a 1,4-cineole 2-exo-monooxygenase. {ECO:0000269PubMed:11695850, ECO:0000269PubMed:20061448, ECO:0000269PubMed:21875942, ECO:0000269PubMed:22909231}.

Subcellular Localization

Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.

Disease Associations

Tissue Specificity

Expressed in liver, lung and heart right ventricle. {ECO:0000269PubMed:10768437}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	0
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004497	monooxygenase activity
GO:0005506	iron ion binding
GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
GO:0016712	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
GO:0020037	heme binding

Biological Process

GO:0006805	xenobiotic metabolic process
GO:0008202	steroid metabolic process
GO:0017144	drug metabolic process
GO:0042180	cellular ketone metabolic process
GO:0042738	exogenous drug catabolic process
GO:0044281	small molecule metabolic process
GO:0055114	oxidation-reduction process

Cellular Component

GO:0005789

endoplasmic reticulum membrane

Protein Structure and Domains

PDB ID

InterPro

IPR001128 Cytochrome P450
IPR002401 Cytochrome P450, E-class, group I
IPR002403 Cytochrome P450, E-class, group IV
IPR008067 Cytochrome P450, E-class, group I, CYP2A-like
IPR008068 Cytochrome P450, E-class, group I, CYP2B-like

PFAM

PF00067

PRINTS

PR00385
PR00463
PR00465
PR01684
PR01685

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P20813