Homo sapiens Gene: CYP2F1
Summary
InnateDB Gene IDBG-52537.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CYP2F1
Gene Name cytochrome P450, family 2, subfamily F, polypeptide 1
Synonyms C2F1; CYP2F;
Species Homo sapiens
Ensembl Gene ENSG00000197446
Encoded Proteins
cytochrome P450, family 2, subfamily F, polypeptide 1
cytochrome P450, family 2, subfamily F, polypeptide 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is known to dehydrogenate 3-methylindole, an endogenous toxin derived from the fermentation of tryptophan, as well as xenobiotic substrates such as naphthalene and ethoxycoumarin. This gene is part of a large cluster of cytochrome P450 genes from the CYP2A, CYP2B and CYP2F subfamilies on chromosome 19q. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:41114432-41128366
Strand Forward strand
Band q13.2
Transcripts
ENST00000331105 ENSP00000333534
ENST00000439903 ENSP00000443424
ENST00000526093
ENST00000531409
ENST00000532164 ENSP00000471416
ENST00000534009 ENSP00000470136
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0004497 monooxygenase activity
GO:0005506 iron ion binding
GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
GO:0019825 oxygen binding
GO:0020037 heme binding
GO:0070330 aromatase activity
Biological Process
GO:0006805 xenobiotic metabolic process
GO:0009636 response to toxic substance
GO:0018931 naphthalene metabolic process
GO:0018979 trichloroethylene metabolic process
GO:0044281 small molecule metabolic process
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005789 endoplasmic reticulum membrane
GO:0043231 intracellular membrane-bounded organelle
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
CYP2E1 reactions pathway
Cytochrome P450 - arranged by substrate type pathway
Fatty acids pathway
Xenobiotics pathway
Metabolism pathway
Biological oxidations pathway
Phase 1 - Functionalization of compounds pathway
KEGG
Metabolism of xenobiotics by cytochrome P450 pathway
INOH
Tryptophan degradation pathway
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene 1572
UniGene Hs.558318
RefSeq NM_000774 XM_006723053
HUGO HGNC:2632
OMIM 124070
CCDS CCDS12572
HPRD 00490
IMGT
EMBL
GenPept
RNA Seq Atlas 1572