InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: CYP2F1

Summary

InnateDB Gene

IDBG-52537.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CYP2F1

Gene Name

cytochrome P450, family 2, subfamily F, polypeptide 1

Synonyms

C2F1; CYP2F

Species

Homo sapiens

Ensembl Gene

ENSG00000197446

Encoded Proteins

IDBP-52539

cytochrome P450, family 2, subfamily F, polypeptide 1

IDBP-587884

cytochrome P450, family 2, subfamily F, polypeptide 1

IDBP-766008

IDBP-761555

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is known to dehydrogenate 3-methylindole, an endogenous toxin derived from the fermentation of tryptophan, as well as xenobiotic substrates such as naphthalene and ethoxycoumarin. This gene is part of a large cluster of cytochrome P450 genes from the CYP2A, CYP2B and CYP2F subfamilies on chromosome 19q. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 19:41114432-41128366

Strand

Forward strand

Band

q13.2

Transcripts

ENST00000331105	ENSP00000333534
ENST00000439903	ENSP00000443424
ENST00000526093
ENST00000531409
ENST00000532164	ENSP00000471416
ENST00000534009	ENSP00000470136

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004497	monooxygenase activity
GO:0005506	iron ion binding
GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
GO:0016712	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
GO:0019825	oxygen binding
GO:0020037	heme binding
GO:0070330	aromatase activity

Biological Process

GO:0006805	xenobiotic metabolic process
GO:0009636	response to toxic substance
GO:0018931	naphthalene metabolic process
GO:0018979	trichloroethylene metabolic process
GO:0044281	small molecule metabolic process
GO:0055114	oxidation-reduction process

Cellular Component

GO:0005789	endoplasmic reticulum membrane
GO:0043231	intracellular membrane-bounded organelle

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000052974

View Gene Order

ENSBTAG00000046805

Not yet available

Pathways

NETPATH

REACTOME

REACT_13814

Fatty acids pathway

REACT_13797

CYP2E1 reactions pathway

REACT_13543

Xenobiotics pathway

REACT_13567

Cytochrome P450 - arranged by substrate type pathway

REACT_111217

Metabolism pathway

REACT_13433

Biological oxidations pathway

REACT_13705

Phase 1 - Functionalization of compounds pathway

KEGG

hsa00980

Metabolism of xenobiotics by cytochrome P450 pathway

INOH

INOH website

Tryptophan degradation pathway

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.558318

RefSeq

NM_000774 XM_006723053

HUGO

OMIM

CCDS

CCDS12572

HPRD

00490

IMGT

EMBL

GenPept

RNA Seq Atlas