Homo sapiens Gene: NBR1
Summary
InnateDB Gene IDBG-52662.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NBR1
Gene Name neighbor of BRCA1 gene 1
Synonyms 1A1-3B; IAI3B; M17S2;
Species Homo sapiens
Ensembl Gene ENSG00000188554
Encoded Proteins
neighbor of BRCA1 gene 1
neighbor of BRCA1 gene 1
neighbor of BRCA1 gene 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene was originally identified as an ovarian tumor antigen monitored in ovarian cancer. The encoded protein contains a B-box/coiled coil motif, which is present in many genes with transformation potential, but the function of this protein is unknown. This gene is located on a region of chromosome 17q21.1 that is in close proximity to tumor suppressor gene BRCA1. Three alternatively spliced variants encoding the same protein have been identified for this gene. [provided by RefSeq, Jul 2008]
The protein encoded by this gene was originally identified as an ovarian tumor antigen monitored in ovarian cancer. The encoded protein contains a B-box/coiled-coil motif, which is present in many genes with transformation potential. It functions as a specific autophagy receptor for the selective autophagic degradation of peroxisomes by forming intracellular inclusions with ubiquitylated autophagic substrates. This gene is located on a region of chromosome 17q21.1 that is in close proximity to the BRCA1 tumor suppressor gene. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Apr 2014]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:43170481-43211689
Strand Forward strand
Band q21.31
Transcripts
ENST00000341165 ENSP00000343479
ENST00000422280 ENSP00000411250
ENST00000542611 ENSP00000437545
ENST00000592304
ENST00000585505
ENST00000586650 ENSP00000466071
ENST00000590996 ENSP00000466667
ENST00000589872 ENSP00000467816
ENST00000617399
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 200 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.
Experimentally validated
Total 200 [view]
Protein-Protein 192 [view]
Protein-DNA 8 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 9 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0043130 ubiquitin binding
GO:0051019 mitogen-activated protein kinase binding
Biological Process
GO:0016236 macroautophagy
GO:0030500 regulation of bone mineralization
GO:0032872 regulation of stress-activated MAPK cascade
GO:0045668 negative regulation of osteoblast differentiation
GO:0051259 protein oligomerization
Cellular Component
GO:0000407 pre-autophagosomal structure
GO:0005764 lysosome
GO:0005770 late endosome
GO:0005776 autophagic vacuole
GO:0005829 cytosol
GO:0016020 membrane
GO:0031410 cytoplasmic vesicle
GO:0031430 M band
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Cross-References
SwissProt
TrEMBL B7Z5R6
UniProt Splice Variant
Entrez Gene 4077
UniGene Hs.277721
RefSeq NM_001291572 NM_001291571 NM_005899 NM_031858 NM_031862
HUGO HGNC:6746
OMIM 166945
CCDS CCDS45694
HPRD 01326
IMGT
EMBL AC060780 AC109326 AK299328
GenPept BAH13002
RNA Seq Atlas 4077