InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: NBR1

Summary

InnateDB Gene

IDBG-52662.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NBR1

Gene Name

neighbor of BRCA1 gene 1

Synonyms

1A1-3B; IAI3B; M17S2

Species

Homo sapiens

Ensembl Gene

ENSG00000188554

Encoded Proteins

IDBP-52664

neighbor of BRCA1 gene 1

IDBP-379319

neighbor of BRCA1 gene 1

IDBP-595135

neighbor of BRCA1 gene 1

IDBP-764743

IDBP-760617

IDBP-763987

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The protein encoded by this gene was originally identified as an ovarian tumor antigen monitored in ovarian cancer. The encoded protein contains a B-box/coiled coil motif, which is present in many genes with transformation potential, but the function of this protein is unknown. This gene is located on a region of chromosome 17q21.1 that is in close proximity to tumor suppressor gene BRCA1. Three alternatively spliced variants encoding the same protein have been identified for this gene. [provided by RefSeq, Jul 2008]
The protein encoded by this gene was originally identified as an ovarian tumor antigen monitored in ovarian cancer. The encoded protein contains a B-box/coiled-coil motif, which is present in many genes with transformation potential. It functions as a specific autophagy receptor for the selective autophagic degradation of peroxisomes by forming intracellular inclusions with ubiquitylated autophagic substrates. This gene is located on a region of chromosome 17q21.1 that is in close proximity to the BRCA1 tumor suppressor gene. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Apr 2014]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 17:43170481-43211689

Strand

Forward strand

Band

q21.31

Transcripts

ENST00000341165	ENSP00000343479
ENST00000422280	ENSP00000411250
ENST00000542611	ENSP00000437545
ENST00000592304
ENST00000585505
ENST00000586650	ENSP00000466071
ENST00000590996	ENSP00000466667
ENST00000589872	ENSP00000467816
ENST00000617399

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 200 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.

Experimentally validated
Total	200 [view]
Protein-Protein	192 [view]
Protein-DNA	8 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	9 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0043130	ubiquitin binding
GO:0051019	mitogen-activated protein kinase binding

Biological Process

GO:0016236	macroautophagy
GO:0030500	regulation of bone mineralization
GO:0032872	regulation of stress-activated MAPK cascade
GO:0045668	negative regulation of osteoblast differentiation
GO:0051259	protein oligomerization

Cellular Component

GO:0000407	pre-autophagosomal structure
GO:0005764	lysosome
GO:0005770	late endosome
GO:0005776	autophagic vacuole
GO:0005829	cytosol
GO:0016020	membrane
GO:0031410	cytoplasmic vesicle
GO:0031430	M band
GO:0070062	extracellular vesicular exosome

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000017119

View Gene Order

ENSBTAG00000001632

Not yet available

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.277721

RefSeq

NM_001291571 NM_001291572 NM_005899 NM_031858 NM_031862

HUGO

OMIM

CCDS

CCDS45694

HPRD

01326

IMGT

EMBL

GenPept

RNA Seq Atlas