Homo sapiens Gene: DHX8
Summary
InnateDB Gene IDBG-52812.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DHX8
Gene Name DEAH (Asp-Glu-Ala-His) box polypeptide 8
Synonyms DDX8; HRH1; PRP22; PRPF22;
Species Homo sapiens
Ensembl Gene ENSG00000067596
Encoded Proteins
DEAH (Asp-Glu-Ala-His) box polypeptide 8
DEAH (Asp-Glu-Ala-His) box polypeptide 8
DEAH (Asp-Glu-Ala-His) box polypeptide 8
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, which is highly homologous to yeast Prp22. This protein facilitates nuclear export of spliced mRNA by releasing the RNA from the spliceosome. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:43483865-43544463
Strand Forward strand
Band q21.31
Transcripts
ENST00000262415 ENSP00000262415
ENST00000540306 ENSP00000437886
ENST00000592258 ENSP00000467834
ENST00000587574 ENSP00000465178
ENST00000587044
ENST00000589898 ENSP00000466900
ENST00000605777 ENSP00000474654
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 50 experimentally validated interaction(s) in this database.
Experimentally validated
Total 50 [view]
Protein-Protein 49 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003676 nucleic acid binding
GO:0003723 RNA binding
GO:0004004 ATP-dependent RNA helicase activity
GO:0004386 helicase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008026 ATP-dependent helicase activity
GO:0042802 identical protein binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0000398 mRNA splicing, via spliceosome
GO:0006200 ATP catabolic process
GO:0006396 RNA processing
GO:0006810 transport
GO:0008380 RNA splicing
Cellular Component
GO:0005634 nucleus
GO:0005681 spliceosomal complex
GO:0071013 catalytic step 2 spliceosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
KEGG
Spliceosome pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.463105 Hs.666018 Hs.737257
RefSeq NM_004941 XM_005257113 XM_005257114
HUGO
OMIM
CCDS CCDS11464
HPRD 02672
IMGT
EMBL
GenPept
RNA Seq Atlas