InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: DHX8

Summary

InnateDB Protein

IDBP-52814.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

DHX8

Protein Name

DEAH (Asp-Glu-Ala-His) box polypeptide 8

Synonyms

DDX8; HRH1; PRP22; PRPF22;

Species

Homo sapiens

Ensembl Protein

ENSP00000262415

InnateDB Gene

IDBG-52812 (DHX8)

Protein Structure

UniProt Annotation

Function

Facilitates nuclear export of spliced mRNA by releasing the RNA from the spliceosome. {ECO:0000269PubMed:8608946}.

Subcellular Localization

Nucleus.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 50 experimentally validated interaction(s) in this database.

Experimentally validated
Total	50 [view]
Protein-Protein	49 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003676	nucleic acid binding
GO:0004004	ATP-dependent RNA helicase activity
GO:0004386	helicase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0042802	identical protein binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0000398	mRNA splicing, via spliceosome
GO:0006200	ATP catabolic process
GO:0006396	RNA processing
GO:0008380	RNA splicing

Cellular Component

GO:0005634	nucleus
GO:0005681	spliceosomal complex
GO:0071013	catalytic step 2 spliceosome

Protein Structure and Domains

PDB ID

InterPro

IPR001650 Helicase, C-terminal
IPR003029 Ribosomal protein S1, RNA-binding domain
IPR007502 Helicase-associated domain
IPR011545 DEAD/DEAH box helicase domain
IPR011709 Domain of unknown function DUF1605
IPR012340 Nucleic acid-binding, OB-fold
IPR014001 Helicase, superfamily 1/2, ATP-binding domain
IPR022967 RNA-binding domain, S1
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF00271
PF00575
PF04408
PF00270
PF07717

PRINTS

PIRSF

SMART

SM00490
SM00847
SM00487
SM00316

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q14562