Version 5.4
Homo sapiens Gene: RPS6
Summary
InnateDB Gene IDBG-52818.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RPS6
Gene Name ribosomal protein S6
Synonyms S6
Species Homo sapiens
Ensembl Gene ENSG00000137154
Encoded Proteins
IDBP-52820
ribosomal protein S6
IDBP-52822
ribosomal protein S6
IDBP-52824
ribosomal protein S6
IDBP-52826
ribosomal protein S6
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a cytoplasmic ribosomal protein that is a component of the 40S subunit. The protein belongs to the S6E family of ribosomal proteins. It is the major substrate of protein kinases in the ribosome, with subsets of five C-terminal serine residues phosphorylated by different protein kinases. Phosphorylation is induced by a wide range of stimuli, including growth factors, tumor-promoting agents, and mitogens. Dephosphorylation occurs at growth arrest. The protein may contribute to the control of cell growth and proliferation through the selective translation of particular classes of mRNA. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 9:19375715-19380254
Strand Reverse strand
Band p22.1
Transcripts
ENST00000380394 ENSP00000369757
ENST00000380384 ENSP00000369745
ENST00000315377 ENSP00000369743
ENST00000380381 ENSP00000369741
ENST00000498815
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 201 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.
Experimentally validated
Total 201 [view]
Protein-Protein 198 [view]
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 7 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003735 structural constituent of ribosome
GO:0005515 protein binding
GO:0019901 protein kinase binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0000028 ribosomal small subunit assembly
GO:0000082 G1/S transition of mitotic cell cycle
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
GO:0001890 placenta development
GO:0002309 T cell proliferation involved in immune response
GO:0006364 rRNA processing
GO:0006412 translation
GO:0006413 translational initiation
GO:0006414 translational elongation
GO:0006415 translational termination
GO:0006614 SRP-dependent cotranslational protein targeting to membrane
GO:0006924 activation-induced cell death of T cells
GO:0007067 mitotic nuclear division
GO:0007093 mitotic cell cycle checkpoint
GO:0007369 gastrulation
GO:0008286 insulin receptor signaling pathway
GO:0010467 gene expression
GO:0016032 viral process
GO:0016070 RNA metabolic process
GO:0016071 mRNA metabolic process
GO:0019058 viral life cycle
GO:0019083 viral transcription
GO:0022605 oogenesis stage
GO:0031929 TOR signaling
GO:0033077 T cell differentiation in thymus
GO:0042274 ribosomal small subunit biogenesis
GO:0042593 glucose homeostasis
GO:0043065 positive regulation of apoptotic process
GO:0043066 negative regulation of apoptotic process
GO:0044267 cellular protein metabolic process
GO:0048821 erythrocyte development
Cellular Component
GO:0005622 intracellular
GO:0005634 nucleus
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005840 ribosome
GO:0005844 polysome
GO:0015935 small ribosomal subunit
GO:0016020 membrane
GO:0022627 cytosolic small ribosomal subunit
GO:0030425 dendrite
GO:0030529 ribonucleoprotein complex
GO:0036464 cytoplasmic ribonucleoprotein granule
GO:0044297 cell body
GO:0048471 perinuclear region of cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000028495
View Gene Order
ENSBTAG00000005315
Not yet available
Pathways
NETPATH
NetPath_6
KitReceptor pathway
NetPath_12
BCR pathway
NetPath_14
IL2 pathway
NetPath_22
Leptin pathway
NetPath_23
TSH pathway
NetPath_24
TSLP pathway
NetPath_25
FSH pathway
NetPath_56
Prolactin pathway
NetPath_147
IL11 pathway
REACTOME
REACT_79
L13a-mediated translational silencing of Ceruloplasmin expression pathway
REACT_6772
S6K1 signalling pathway
REACT_6754
S6K1-mediated signalling pathway
REACT_6838
mTOR signalling pathway
REACT_976
PI3K Cascade pathway
REACT_498
Signaling by Insulin receptor pathway
REACT_150203
IRS-related events triggered by IGF1R pathway
REACT_150359
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) pathway
REACT_75768
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) pathway
REACT_75822
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) pathway
REACT_2085
GTP hydrolysis and joining of the 60S ribosomal subunit pathway
REACT_1979
Translation initiation complex formation pathway
REACT_1258
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S pathway
REACT_1797
Formation of a pool of free 40S subunits pathway
REACT_1079
Formation of the ternary complex, and subsequently, the 43S complex pathway
REACT_931
Ribosomal scanning and start codon recognition pathway
REACT_1986
Eukaryotic Translation Termination pathway
REACT_1404
Peptide chain elongation pathway
REACT_1477
Eukaryotic Translation Elongation pathway
REACT_115902
SRP-dependent cotranslational protein targeting to membrane pathway
REACT_9491
Viral mRNA Translation pathway
REACT_2159
Eukaryotic Translation Initiation pathway
REACT_6167
Influenza Infection pathway
REACT_456
PKB-mediated events pathway
REACT_75886
Nonsense-Mediated Decay (NMD) pathway
REACT_6964
mTORC1-mediated signalling pathway
REACT_6152
Influenza Viral RNA Transcription and Replication pathway
REACT_1014
Translation pathway
REACT_111102
Signal Transduction pathway
REACT_332
IRS-mediated signalling pathway
REACT_17015
Metabolism of proteins pathway
REACT_1195
Insulin receptor signalling cascade pathway
REACT_2099
Cap-dependent Translation Initiation pathway
REACT_762
IRS-related events pathway
REACT_150210
IGF1R signaling cascade pathway
REACT_6145
Influenza Life Cycle pathway
REACT_71
Gene Expression pathway
REACT_116125
Disease pathway
KEGG
hsa04150
mTOR signaling pathway pathway
hsa03010
Ribosome pathway
hsa04910
Insulin signaling pathway pathway
INOH
INOH website
Insulin receptor signaling pathway
PID NCI
erbb1_downstream_pathway
ErbB1 downstream signaling
il2_pi3kpathway
IL2 signaling events mediated by PI3K
Cross-References
SwissProt P62753
TrEMBL A2A3R5 A2A3R6 A2A3R7
UniProt Splice Variant
Entrez Gene 6194
UniGene Hs.620064
RefSeq NM_001010
HUGO HGNC:10429
OMIM 180460
CCDS CCDS6492
HPRD
IMGT
EMBL AB062123 AK291517 AK311861 AL391834 BC000524 BC009427 BC027620 BC071907 BC071908 BC094826 CH471071 J03537 M20020 M77232 X67309
GenPept AAA60287 AAA60288 AAA60289 AAH00524 AAH09427 AAH27620 AAH71907 AAH71908 AAH94826 BAB93455 BAF84206 BAG34802 CAA47719 EAW58635 EAW58640 EAW58641 EAW58643
RNA Seq Atlas 6194

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca