Homo sapiens Gene: TGFB1
Summary
InnateDB Gene IDBG-52846.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TGFB1
Gene Name transforming growth factor, beta 1
Synonyms CED; DPD1; LAP; TGFB; TGFbeta;
Species Homo sapiens
Ensembl Gene ENSG00000105329
Encoded Proteins
transforming growth factor, beta 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation from Orthologs
Summary
[Mus musculus] Epithelial cell-derived cytokine Tgfb1 has a central role in the generation of the pulmonary immune response by enhancing the chemoactivity of type 2 innate lymphoid cells.
Entrez Gene
Summary This gene encodes a member of the transforming growth factor beta (TGFB) family of cytokines, which are multifunctional peptides that regulate proliferation, differentiation, adhesion, migration, and other functions in many cell types. Many cells have TGFB receptors, and the protein positively and negatively regulates many other growth factors. The secreted protein is cleaved into a latency-associated peptide (LAP) and a mature TGFB1 peptide, and is found in either a latent form composed of a TGFB1 homodimer, a LAP homodimer, and a latent TGFB1-binding protein, or in an active form composed of a TGFB1 homodimer. The mature peptide may also form heterodimers with other TGFB family members. This gene is frequently upregulated in tumor cells, and mutations in this gene result in Camurati-Engelmann disease.[provided by RefSeq, Oct 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:41301587-41353911
Strand Reverse strand
Band q13.2
Transcripts
ENST00000221930 ENSP00000221930
ENST00000600196
ENST00000597453
ENST00000598758 ENSP00000472767
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 66 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.
Experimentally validated
Total 66 [view]
Protein-Protein 57 [view]
Protein-DNA 5 [view]
Protein-RNA 4 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 7 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001948 glycoprotein binding
GO:0003823 antigen binding
GO:0005114 type II transforming growth factor beta receptor binding
GO:0005125 cytokine activity
GO:0005515 protein binding
GO:0008083 growth factor activity
GO:0019899 enzyme binding
GO:0042803 protein homodimerization activity
GO:0046982 protein heterodimerization activity
GO:0047485 protein N-terminus binding
Biological Process
GO:0000060 protein import into nucleus, translocation
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0000165 MAPK cascade
GO:0001657 ureteric bud development
GO:0001666 response to hypoxia
GO:0001763 morphogenesis of a branching structure
GO:0001775 cell activation
GO:0001837 epithelial to mesenchymal transition
GO:0001933 negative regulation of protein phosphorylation
GO:0001934 positive regulation of protein phosphorylation
GO:0002028 regulation of sodium ion transport
GO:0002062 chondrocyte differentiation
GO:0002244 hematopoietic progenitor cell differentiation
GO:0002248 connective tissue replacement involved in inflammatory response wound healing
GO:0002460 adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
GO:0002513 tolerance induction to self antigen
GO:0002576 platelet degranulation
GO:0006468 protein phosphorylation
GO:0006611 protein export from nucleus
GO:0006754 ATP biosynthetic process
GO:0006796 phosphate-containing compound metabolic process
GO:0006874 cellular calcium ion homeostasis
GO:0006954 inflammatory response
GO:0007050 cell cycle arrest
GO:0007093 mitotic cell cycle checkpoint
GO:0007173 epidermal growth factor receptor signaling pathway
GO:0007179 transforming growth factor beta receptor signaling pathway
GO:0007182 common-partner SMAD protein phosphorylation
GO:0007183 SMAD protein complex assembly
GO:0007184 SMAD protein import into nucleus
GO:0007406 negative regulation of neuroblast proliferation
GO:0007435 salivary gland morphogenesis
GO:0007492 endoderm development
GO:0007565 female pregnancy
GO:0007568 aging
GO:0007596 blood coagulation
GO:0008156 negative regulation of DNA replication
GO:0008283 cell proliferation
GO:0008284 positive regulation of cell proliferation
GO:0008285 negative regulation of cell proliferation
GO:0008354 germ cell migration
GO:0009314 response to radiation
GO:0009611 response to wounding
GO:0009749 response to glucose
GO:0009817 defense response to fungus, incompatible interaction
GO:0010033 response to organic substance
GO:0010575 positive regulation vascular endothelial growth factor production
GO:0010628 positive regulation of gene expression
GO:0010629 negative regulation of gene expression
GO:0010716 negative regulation of extracellular matrix disassembly
GO:0010718 positive regulation of epithelial to mesenchymal transition
GO:0010742 macrophage derived foam cell differentiation
GO:0010763 positive regulation of fibroblast migration
GO:0010800 positive regulation of peptidyl-threonine phosphorylation
GO:0010862 positive regulation of pathway-restricted SMAD protein phosphorylation
GO:0010936 negative regulation of macrophage cytokine production
GO:0014070 response to organic cyclic compound
GO:0016049 cell growth
GO:0016202 regulation of striated muscle tissue development
GO:0017015 regulation of transforming growth factor beta receptor signaling pathway
GO:0019048 modulation by virus of host morphology or physiology
GO:0019049 evasion or tolerance of host defenses by virus
GO:0019058 viral life cycle
GO:0022408 negative regulation of cell-cell adhesion
GO:0030168 platelet activation
GO:0030198 extracellular matrix organization
GO:0030214 hyaluronan catabolic process
GO:0030217 T cell differentiation
GO:0030279 negative regulation of ossification
GO:0030308 negative regulation of cell growth
GO:0030334 regulation of cell migration
GO:0030335 positive regulation of cell migration
GO:0030501 positive regulation of bone mineralization
GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway
GO:0030879 mammary gland development
GO:0031065 positive regulation of histone deacetylation
GO:0031100 organ regeneration
GO:0031334 positive regulation of protein complex assembly
GO:0031536 positive regulation of exit from mitosis
GO:0031663 lipopolysaccharide-mediated signaling pathway
GO:0032270 positive regulation of cellular protein metabolic process
GO:0032355 response to estradiol
GO:0032570 response to progesterone
GO:0032740 positive regulation of interleukin-17 production
GO:0032801 receptor catabolic process
GO:0032930 positive regulation of superoxide anion generation
GO:0032943 mononuclear cell proliferation
GO:0032967 positive regulation of collagen biosynthetic process
GO:0033138 positive regulation of peptidyl-serine phosphorylation
GO:0033280 response to vitamin D
GO:0034616 response to laminar fluid shear stress
GO:0035066 positive regulation of histone acetylation
GO:0035307 positive regulation of protein dephosphorylation
GO:0040007 growth
GO:0042060 wound healing
GO:0042110 T cell activation
GO:0042127 regulation of cell proliferation
GO:0042130 negative regulation of T cell proliferation
GO:0042306 regulation of protein import into nucleus
GO:0042307 positive regulation of protein import into nucleus
GO:0042482 positive regulation of odontogenesis
GO:0042493 response to drug
GO:0042552 myelination
GO:0043011 myeloid dendritic cell differentiation
GO:0043029 T cell homeostasis
GO:0043065 positive regulation of apoptotic process
GO:0043406 positive regulation of MAP kinase activity
GO:0043491 protein kinase B signaling
GO:0043536 positive regulation of blood vessel endothelial cell migration
GO:0043537 negative regulation of blood vessel endothelial cell migration
GO:0043552 positive regulation of phosphatidylinositol 3-kinase activity
GO:0043932 ossification involved in bone remodeling
GO:0045066 regulatory T cell differentiation
GO:0045087 innate immune response
GO:0045216 cell-cell junction organization
GO:0045599 negative regulation of fat cell differentiation
GO:0045662 negative regulation of myoblast differentiation
GO:0045786 negative regulation of cell cycle
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045930 negative regulation of mitotic cell cycle
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0046732 active induction of host immune response by virus
GO:0048298 positive regulation of isotype switching to IgA isotypes
GO:0048535 lymph node development
GO:0048565 digestive tract development
GO:0048642 negative regulation of skeletal muscle tissue development
GO:0048839 inner ear development
GO:0050679 positive regulation of epithelial cell proliferation
GO:0050680 negative regulation of epithelial cell proliferation
GO:0050714 positive regulation of protein secretion
GO:0050765 negative regulation of phagocytosis
GO:0050777 negative regulation of immune response
GO:0050868 negative regulation of T cell activation
GO:0050921 positive regulation of chemotaxis
GO:0051092 positive regulation of NF-kappaB transcription factor activity
GO:0051098 regulation of binding
GO:0051101 regulation of DNA binding
GO:0051152 positive regulation of smooth muscle cell differentiation
GO:0051280 negative regulation of release of sequestered calcium ion into cytosol
GO:0051781 positive regulation of cell division
GO:0051897 positive regulation of protein kinase B signaling
GO:0060312 regulation of blood vessel remodeling
GO:0060325 face morphogenesis
GO:0060364 frontal suture morphogenesis
GO:0060389 pathway-restricted SMAD protein phosphorylation
GO:0060391 positive regulation of SMAD protein import into nucleus
GO:0060744 mammary gland branching involved in thelarche
GO:0060751 branch elongation involved in mammary gland duct branching
GO:0060762 regulation of branching involved in mammary gland duct morphogenesis
GO:0061035 regulation of cartilage development
GO:0070306 lens fiber cell differentiation
GO:0070723 response to cholesterol
GO:0071158 positive regulation of cell cycle arrest
GO:0071363 cellular response to growth factor stimulus
GO:0071407 cellular response to organic cyclic compound
GO:0071549 cellular response to dexamethasone stimulus
GO:0071560 cellular response to transforming growth factor beta stimulus
GO:0085029 extracellular matrix assembly
GO:0090190 positive regulation of branching involved in ureteric bud morphogenesis
GO:0097191 extrinsic apoptotic signaling pathway
GO:1900126 negative regulation of hyaluronan biosynthetic process
GO:1900182 positive regulation of protein localization to nucleus
GO:1901203 positive regulation of extracellular matrix assembly
GO:1901666 positive regulation of NAD+ ADP-ribosyltransferase activity
GO:2000249 regulation of actin cytoskeleton reorganization
GO:2000628 regulation of miRNA metabolic process
GO:2000679 positive regulation of transcription regulatory region DNA binding
Cellular Component
GO:0005576 extracellular region
GO:0005578 proteinaceous extracellular matrix
GO:0005615 extracellular space
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005796 Golgi lumen
GO:0005886 plasma membrane
GO:0005902 microvillus
GO:0009986 cell surface
GO:0030141 secretory granule
GO:0030424 axon
GO:0031012 extracellular matrix
GO:0031093 platelet alpha granule lumen
GO:0043025 neuronal cell body
GO:0072562 blood microparticle
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
TGF_beta_Receptor pathway
REACTOME
SMAD4 MH2 Domain Mutants in Cancer pathway
Developmental Biology pathway
Influenza Infection pathway
Loss of Function of SMAD4 in Cancer pathway
Loss of Function of SMAD2/3 in Cancer pathway
Elastic fibre formation pathway
Extracellular matrix organization pathway
Molecules associated with elastic fibres pathway
Signaling by TGF-beta Receptor Complex in Cancer pathway
Syndecan interactions pathway
Platelet degranulation pathway
Platelet activation, signaling and aggregation pathway
TGFBR2 MSI Frameshift Mutants in Cancer pathway
Signal Transduction pathway
SMAD2/3 MH2 Domain Mutants in Cancer pathway
Loss of Function of TGFBR2 in Cancer pathway
SMAD2/3 Phosphorylation Motif Mutants in Cancer pathway
ECM proteoglycans pathway
Non-integrin membrane-ECM interactions pathway
Downregulation of TGF-beta receptor signaling pathway
Response to elevated platelet cytosolic Ca2+ pathway
TGFBR1 KD Mutants in Cancer pathway
Loss of Function of TGFBR1 in Cancer pathway
TGFBR1 LBD Mutants in Cancer pathway
Transcriptional regulation of white adipocyte differentiation pathway
TGFBR2 Kinase Domain Mutants in Cancer pathway
TGF-beta receptor signaling activates SMADs pathway
Host Interactions with Influenza Factors pathway
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) pathway
Disease pathway
Influenza Virus Induced Apoptosis pathway
Hemostasis pathway
Signaling by TGF-beta Receptor Complex pathway
KEGG
MAPK signaling pathway pathway
Cytokine-cytokine receptor interaction pathway
Cell cycle pathway
Endocytosis pathway
TGF-beta signaling pathway pathway
Osteoclast differentiation pathway
Intestinal immune network for IgA production pathway
Leishmaniasis pathway
Chagas disease (American trypanosomiasis) pathway
Malaria pathway
Toxoplasmosis pathway
Amoebiasis pathway
Pathways in cancer pathway
Colorectal cancer pathway
Renal cell carcinoma pathway
Pancreatic cancer pathway
Chronic myeloid leukemia pathway
Hypertrophic cardiomyopathy (HCM) pathway
Dilated cardiomyopathy pathway
INOH
GPCR signaling pathway
TGF-beta signaling pathway
BMP2 signaling pathway
PID BIOCARTA
Cell cycle: g1/s check point [Biocarta view]
Tgf beta signaling pathway [Biocarta view]
Ctcf: first multivalent nuclear factor [Biocarta view]
Signal transduction through il1r [Biocarta view]
Alk in cardiac myocytes [Biocarta view]
Nfkb activation by nontypeable hemophilus influenzae [Biocarta view]
PID NCI
Syndecan-2-mediated signaling events
RXR and RAR heterodimerization with other nuclear receptor
IL27-mediated signaling events
Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
ALK1 signaling events
IL12 signaling mediated by STAT4
AP-1 transcription factor network
Syndecan-1-mediated signaling events
Regulation of Telomerase
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.611591 Hs.645227
RefSeq NM_000660
HUGO
OMIM
CCDS CCDS33031
HPRD 01821
IMGT
EMBL
GenPept
RNA Seq Atlas