InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: TGFB1

Summary

InnateDB Protein

IDBP-52848.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TGFB1

Protein Name

transforming growth factor, beta 1

Synonyms

CED; DPD1; LAP; TGFB; TGFbeta;

Species

Homo sapiens

Ensembl Protein

ENSP00000221930

InnateDB Gene

IDBG-52846 (TGFB1)

Protein Structure

UniProt Annotation

Function

Multifunctional protein that controls proliferation, differentiation and other functions in many cell types. Many cells synthesize TGFB1 and have specific receptors for it. It positively and negatively regulates many other growth factors. It plays an important role in bone remodeling as it is a potent stimulator of osteoblastic bone formation, causing chemotaxis, proliferation and differentiation in committed osteoblasts.

Subcellular Localization

Secreted, extracellular space, extracellular matrix {ECO:0000269PubMed:17827158}.

Disease Associations

Camurati-Engelmann disease (CE) [MIM:131300]: Autosomal dominant disorder characterized by hyperostosis and sclerosis of the diaphyses of long bones. The disease typically presents in early childhood with pain, muscular weakness and waddling gait, and in some cases other features such as exophthalmos, facial paralysis, hearing difficulties and loss of vision. {ECO:0000269PubMed:10973241, ECO:0000269PubMed:11062463, ECO:0000269PubMed:15103729}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Highly expressed in bone. Abundantly expressed in articular cartilage and chondrocytes and is increased in osteoarthritis (OA). Colocalizes with ASPN in chondrocytes within OA lesions of articular cartilage. {ECO:0000269PubMed:11746498, ECO:0000269PubMed:17827158}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 66 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.

Experimentally validated
Total	66 [view]
Protein-Protein	57 [view]
Protein-DNA	5 [view]
Protein-RNA	4 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	7 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001948	glycoprotein binding
GO:0003823	antigen binding
GO:0005114	type II transforming growth factor beta receptor binding
GO:0005125	cytokine activity
GO:0005515	protein binding
GO:0008083	growth factor activity
GO:0019899	enzyme binding
GO:0042803	protein homodimerization activity
GO:0046982	protein heterodimerization activity
GO:0047485	protein N-terminus binding

Biological Process

GO:0000060	protein import into nucleus, translocation
GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0000165	MAPK cascade
GO:0001657	ureteric bud development
GO:0001666	response to hypoxia
GO:0001763	morphogenesis of a branching structure
GO:0001775	cell activation
GO:0001837	epithelial to mesenchymal transition
GO:0001933	negative regulation of protein phosphorylation
GO:0001934	positive regulation of protein phosphorylation
GO:0002028	regulation of sodium ion transport
GO:0002062	chondrocyte differentiation
GO:0002244	hematopoietic progenitor cell differentiation
GO:0002248	connective tissue replacement involved in inflammatory response wound healing
GO:0002460	adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
GO:0002513	tolerance induction to self antigen
GO:0002576	platelet degranulation
GO:0006468	protein phosphorylation
GO:0006611	protein export from nucleus
GO:0006754	ATP biosynthetic process
GO:0006796	phosphate-containing compound metabolic process
GO:0006874	cellular calcium ion homeostasis
GO:0006954	inflammatory response
GO:0007050	cell cycle arrest
GO:0007093	mitotic cell cycle checkpoint
GO:0007173	epidermal growth factor receptor signaling pathway
GO:0007179	transforming growth factor beta receptor signaling pathway
GO:0007182	common-partner SMAD protein phosphorylation
GO:0007183	SMAD protein complex assembly
GO:0007184	SMAD protein import into nucleus
GO:0007406	negative regulation of neuroblast proliferation
GO:0007435	salivary gland morphogenesis
GO:0007492	endoderm development
GO:0007565	female pregnancy
GO:0007568	aging
GO:0007596	blood coagulation
GO:0008156	negative regulation of DNA replication
GO:0008283	cell proliferation
GO:0008284	positive regulation of cell proliferation
GO:0008285	negative regulation of cell proliferation
GO:0008354	germ cell migration
GO:0009314	response to radiation
GO:0009611	response to wounding
GO:0009749	response to glucose
GO:0009817	defense response to fungus, incompatible interaction
GO:0010033	response to organic substance
GO:0010575	positive regulation vascular endothelial growth factor production
GO:0010628	positive regulation of gene expression
GO:0010629	negative regulation of gene expression
GO:0010716	negative regulation of extracellular matrix disassembly
GO:0010718	positive regulation of epithelial to mesenchymal transition
GO:0010742	macrophage derived foam cell differentiation
GO:0010763	positive regulation of fibroblast migration
GO:0010800	positive regulation of peptidyl-threonine phosphorylation
GO:0010862	positive regulation of pathway-restricted SMAD protein phosphorylation
GO:0010936	negative regulation of macrophage cytokine production
GO:0014070	response to organic cyclic compound
GO:0016049	cell growth
GO:0016202	regulation of striated muscle tissue development
GO:0017015	regulation of transforming growth factor beta receptor signaling pathway
GO:0019048	modulation by virus of host morphology or physiology
GO:0019049	evasion or tolerance of host defenses by virus
GO:0019058	viral life cycle
GO:0022408	negative regulation of cell-cell adhesion
GO:0030168	platelet activation
GO:0030198	extracellular matrix organization
GO:0030214	hyaluronan catabolic process
GO:0030217	T cell differentiation
GO:0030279	negative regulation of ossification
GO:0030308	negative regulation of cell growth
GO:0030334	regulation of cell migration
GO:0030335	positive regulation of cell migration
GO:0030501	positive regulation of bone mineralization
GO:0030512	negative regulation of transforming growth factor beta receptor signaling pathway
GO:0030879	mammary gland development
GO:0031065	positive regulation of histone deacetylation
GO:0031100	organ regeneration
GO:0031334	positive regulation of protein complex assembly
GO:0031536	positive regulation of exit from mitosis
GO:0031663	lipopolysaccharide-mediated signaling pathway
GO:0032270	positive regulation of cellular protein metabolic process
GO:0032355	response to estradiol
GO:0032570	response to progesterone
GO:0032740	positive regulation of interleukin-17 production
GO:0032801	receptor catabolic process
GO:0032930	positive regulation of superoxide anion generation
GO:0032943	mononuclear cell proliferation
GO:0032967	positive regulation of collagen biosynthetic process
GO:0033138	positive regulation of peptidyl-serine phosphorylation
GO:0033280	response to vitamin D
GO:0034616	response to laminar fluid shear stress
GO:0035066	positive regulation of histone acetylation
GO:0035307	positive regulation of protein dephosphorylation
GO:0040007	growth
GO:0042060	wound healing
GO:0042110	T cell activation
GO:0042127	regulation of cell proliferation
GO:0042130	negative regulation of T cell proliferation
GO:0042306	regulation of protein import into nucleus
GO:0042307	positive regulation of protein import into nucleus
GO:0042482	positive regulation of odontogenesis
GO:0042493	response to drug
GO:0042552	myelination
GO:0043011	myeloid dendritic cell differentiation
GO:0043029	T cell homeostasis
GO:0043065	positive regulation of apoptotic process
GO:0043406	positive regulation of MAP kinase activity
GO:0043491	protein kinase B signaling
GO:0043536	positive regulation of blood vessel endothelial cell migration
GO:0043537	negative regulation of blood vessel endothelial cell migration
GO:0043552	positive regulation of phosphatidylinositol 3-kinase activity
GO:0043932	ossification involved in bone remodeling
GO:0045066	regulatory T cell differentiation
GO:0045087	innate immune response
GO:0045216	cell-cell junction organization
GO:0045599	negative regulation of fat cell differentiation
GO:0045662	negative regulation of myoblast differentiation
GO:0045786	negative regulation of cell cycle
GO:0045892	negative regulation of transcription, DNA-templated
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045930	negative regulation of mitotic cell cycle
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0046732	active induction of host immune response by virus
GO:0048298	positive regulation of isotype switching to IgA isotypes
GO:0048535	lymph node development
GO:0048565	digestive tract development
GO:0048642	negative regulation of skeletal muscle tissue development
GO:0048839	inner ear development
GO:0050679	positive regulation of epithelial cell proliferation
GO:0050680	negative regulation of epithelial cell proliferation
GO:0050714	positive regulation of protein secretion
GO:0050765	negative regulation of phagocytosis
GO:0050777	negative regulation of immune response
GO:0050868	negative regulation of T cell activation
GO:0050921	positive regulation of chemotaxis
GO:0051092	positive regulation of NF-kappaB transcription factor activity
GO:0051098	regulation of binding
GO:0051101	regulation of DNA binding
GO:0051152	positive regulation of smooth muscle cell differentiation
GO:0051280	negative regulation of release of sequestered calcium ion into cytosol
GO:0051781	positive regulation of cell division
GO:0051897	positive regulation of protein kinase B signaling
GO:0060312	regulation of blood vessel remodeling
GO:0060325	face morphogenesis
GO:0060364	frontal suture morphogenesis
GO:0060389	pathway-restricted SMAD protein phosphorylation
GO:0060391	positive regulation of SMAD protein import into nucleus
GO:0060744	mammary gland branching involved in thelarche
GO:0060751	branch elongation involved in mammary gland duct branching
GO:0060762	regulation of branching involved in mammary gland duct morphogenesis
GO:0061035	regulation of cartilage development
GO:0070306	lens fiber cell differentiation
GO:0070723	response to cholesterol
GO:0071158	positive regulation of cell cycle arrest
GO:0071363	cellular response to growth factor stimulus
GO:0071407	cellular response to organic cyclic compound
GO:0071549	cellular response to dexamethasone stimulus
GO:0071560	cellular response to transforming growth factor beta stimulus
GO:0085029	extracellular matrix assembly
GO:0090190	positive regulation of branching involved in ureteric bud morphogenesis
GO:0097191	extrinsic apoptotic signaling pathway
GO:1900126	negative regulation of hyaluronan biosynthetic process
GO:1900182	positive regulation of protein localization to nucleus
GO:1901203	positive regulation of extracellular matrix assembly
GO:1901666	positive regulation of NAD+ ADP-ribosyltransferase activity
GO:2000249	regulation of actin cytoskeleton reorganization
GO:2000628	regulation of miRNA metabolic process
GO:2000679	positive regulation of transcription regulatory region DNA binding

Cellular Component

GO:0005576	extracellular region
GO:0005578	proteinaceous extracellular matrix
GO:0005615	extracellular space
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005796	Golgi lumen
GO:0005886	plasma membrane
GO:0005902	microvillus
GO:0009986	cell surface
GO:0030141	secretory granule
GO:0030424	axon
GO:0031012	extracellular matrix
GO:0031093	platelet alpha granule lumen
GO:0043025	neuronal cell body
GO:0072562	blood microparticle

Protein Structure and Domains

PDB ID

InterPro

IPR001111 Transforming growth factor-beta, N-terminal
IPR001839 Transforming growth factor-beta, C-terminal
IPR003939 Transforming growth factor, beta 1
IPR016319 Transforming growth factor-beta
IPR029034 Cystine-knot cytokine

PFAM

PF00688
PF00019

PRINTS

PR01424
PR01423

PIRSF

PIRSF001787

SMART

SM00204

TIGRFAMs

Post-translational Modifications

Modification

Cross-References