Version 5.4
Homo sapiens Gene: ADCY5
Summary
InnateDB Gene IDBG-52972.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ADCY5
Gene Name adenylate cyclase 5
Synonyms AC5; FDFM
Species Homo sapiens
Ensembl Gene ENSG00000173175
Encoded Proteins
IDBP-52974
adenylate cyclase 5
IDBP-485073
adenylate cyclase 5
IDBP-478180
adenylate cyclase 5
IDBP-482872
adenylate cyclase 5
IDBP-474726
adenylate cyclase 5
IDBP-483875
adenylate cyclase 5
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the membrane-bound adenylyl cyclase enzymes. Adenylyl cyclases mediate G protein-coupled receptor signaling through the synthesis of the second messenger cAMP. Activity of the encoded protein is stimulated by the Gs alpha subunit of G protein-coupled receptors and is inhibited by protein kinase A, calcium and Gi alpha subunits. Single nucleotide polymorphisms in this gene may be associated with low birth weight and type 2 diabetes. Alternatively spliced transcript variants that encode different isoforms have been observed for this gene. [provided by RefSeq, Dec 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:123282296-123449758
Strand Reverse strand
Band q21.1
Transcripts
ENST00000309879 ENSP00000308685
ENST00000462833 ENSP00000419361
ENST00000491190 ENSP00000418537
ENST00000478092
ENST00000474577
ENST00000466617 ENSP00000420082
ENST00000468683
ENST00000483566 ENSP00000420252
ENST00000476455 ENSP00000417789
ENST00000470367
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.
Experimentally validated
Total 14 [view]
Protein-Protein 14 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0004016 adenylate cyclase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008179 adenylate cyclase binding
GO:0016849 phosphorus-oxygen lyase activity
GO:0046872 metal ion binding
GO:0046982 protein heterodimerization activity
Biological Process
GO:0001973 adenosine receptor signaling pathway
GO:0006112 energy reserve metabolic process
GO:0006171 cAMP biosynthetic process
GO:0006833 water transport
GO:0007165 signal transduction
GO:0007173 epidermal growth factor receptor signaling pathway
GO:0007189 adenylate cyclase-activating G-protein coupled receptor signaling pathway
GO:0007191 adenylate cyclase-activating dopamine receptor signaling pathway
GO:0007193 adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
GO:0007195 adenylate cyclase-inhibiting dopamine receptor signaling pathway
GO:0007202 activation of phospholipase C activity
GO:0007268 synaptic transmission
GO:0007626 locomotory behavior
GO:0008543 fibroblast growth factor receptor signaling pathway
GO:0009190 cyclic nucleotide biosynthetic process
GO:0034199 activation of protein kinase A activity
GO:0035556 intracellular signal transduction
GO:0044281 small molecule metabolic process
GO:0045087 innate immune response
GO:0048011 neurotrophin TRK receptor signaling pathway
GO:0050885 neuromuscular process controlling balance
GO:0055085 transmembrane transport
GO:0071377 cellular response to glucagon stimulus
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0072372 primary cilium
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000022840
View Gene Order
ENSBTAG00000018777
Not yet available
Pathways
NETPATH
REACTOME
REACT_15530
PKA activation pathway
REACT_15497
PKA-mediated phosphorylation of CREB pathway
REACT_9000
Calmodulin induced events pathway
REACT_9053
CaM pathway pathway
REACT_111064
DAG and IP3 signaling pathway
REACT_147814
DAP12 signaling pathway
REACT_147694
DAP12 interactions pathway
REACT_24023
Vasopressin regulates renal water homeostasis via Aquaporins pathway
REACT_12079
PLC-gamma1 signalling pathway
REACT_12478
EGFR interacts with phospholipase C-gamma pathway
REACT_9417
Signaling by EGFR pathway
REACT_19231
G alpha (i) signalling events pathway
REACT_19327
G alpha (s) signalling events pathway
REACT_19333
G alpha (z) signalling events pathway
REACT_15312
Adenylate cyclase activating pathway pathway
REACT_15333
Adenylate cyclase inhibitory pathway pathway
REACT_15426
PLC beta mediated events pathway
REACT_15295
Opioid Signalling pathway
REACT_115720
PLCG1 events in ERBB2 signaling pathway
REACT_115755
Signaling by ERBB2 pathway
REACT_21310
Phospholipase C-mediated cascade pathway
REACT_9470
Signaling by FGFR pathway
REACT_17025
Downstream signal transduction pathway
REACT_16888
Signaling by PDGF pathway
REACT_25031
GABA B receptor activation pathway
REACT_18274
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion pathway
REACT_18339
Adrenaline,noradrenaline inhibits insulin secretion pathway
REACT_18325
Regulation of insulin secretion pathway
REACT_1946
PKA activation in glucagon signalling pathway
REACT_1665
Glucagon signaling in metabolic regulation pathway
REACT_1505
Integration of energy metabolism pathway
REACT_120736
Signaling by FGFR in disease pathway
REACT_15518
Transmembrane transport of small molecules pathway
REACT_11061
Signalling by NGF pathway
REACT_228134
Signaling by Hedgehog pathway
REACT_115871
Signaling by EGFR in Cancer pathway
REACT_21272
Downstream signaling of activated FGFR pathway
REACT_13685
Neuronal System pathway
REACT_14797
Signaling by GPCR pathway
REACT_6802
Innate Immune System pathway
REACT_25199
GABA receptor activation pathway
REACT_25330
Activation of GABAB receptors pathway
REACT_111102
Signal Transduction pathway
REACT_19184
GPCR downstream signaling pathway
REACT_267634
Hedgehog 'off' state pathway
REACT_15526
G-protein mediated events pathway
REACT_6900
Immune System pathway
REACT_12056
NGF signalling via TRKA from the plasma membrane pathway
REACT_13477
Transmission across Chemical Synapses pathway
REACT_15370
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell pathway
REACT_111217
Metabolism pathway
REACT_25282
Inhibition of adenylate cyclase pathway pathway
REACT_15307
Ca-dependent events pathway
REACT_23887
Aquaporin-mediated transport pathway
REACT_116125
Disease pathway
KEGG
hsa04912
GnRH signaling pathway pathway
hsa04540
Gap junction pathway
hsa00230
Purine metabolism pathway
hsa04916
Melanogenesis pathway
hsa05012
Parkinson's disease pathway
hsa04270
Vascular smooth muscle contraction pathway
hsa04062
Chemokine signaling pathway pathway
hsa04914
Progesterone-mediated oocyte maturation pathway
hsa05414
Dilated cardiomyopathy pathway
hsa04114
Oocyte meiosis pathway
hsa04971
Gastric acid secretion pathway
hsa04972
Pancreatic secretion pathway
hsa04970
Salivary secretion pathway
hsa04976
Bile secretion pathway
INOH
INOH website
GPCR Adenosine A2A receptor signaling pathway pathway
INOH website
Purine nucleotides nucleosides metabolism pathway
INOH website
GPCR Dopamine D1like receptor signaling pathway pathway
INOH website
GPCR signaling pathway
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.593292 Hs.729601
RefSeq NM_001199642 NM_183357
HUGO
OMIM
CCDS CCDS3022 CCDS56274
HPRD 08973
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca