Homo sapiens Gene: ADCY5
InnateDB Gene IDBG-52972.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ADCY5
Gene Name adenylate cyclase 5
Synonyms AC5; FDFM
Species Homo sapiens
Ensembl Gene ENSG00000173175
Encoded Proteins
adenylate cyclase 5
adenylate cyclase 5
adenylate cyclase 5
adenylate cyclase 5
adenylate cyclase 5
adenylate cyclase 5
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the membrane-bound adenylyl cyclase enzymes. Adenylyl cyclases mediate G protein-coupled receptor signaling through the synthesis of the second messenger cAMP. Activity of the encoded protein is stimulated by the Gs alpha subunit of G protein-coupled receptors and is inhibited by protein kinase A, calcium and Gi alpha subunits. Single nucleotide polymorphisms in this gene may be associated with low birth weight and type 2 diabetes. Alternatively spliced transcript variants that encode different isoforms have been observed for this gene. [provided by RefSeq, Dec 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:123282296-123449758
Strand Reverse strand
Band q21.1
ENST00000309879 ENSP00000308685
ENST00000462833 ENSP00000419361
ENST00000491190 ENSP00000418537
ENST00000466617 ENSP00000420082
ENST00000483566 ENSP00000420252
ENST00000476455 ENSP00000417789
Number of Interactions This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.
Experimentally validated
Total 14 [view]
Protein-Protein 14 [view]
Protein-DNA 0
Protein-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0004016 adenylate cyclase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008179 adenylate cyclase binding
GO:0016849 phosphorus-oxygen lyase activity
GO:0046872 metal ion binding
GO:0046982 protein heterodimerization activity
Biological Process
GO:0001973 adenosine receptor signaling pathway
GO:0006112 energy reserve metabolic process
GO:0006171 cAMP biosynthetic process
GO:0006833 water transport
GO:0007165 signal transduction
GO:0007173 epidermal growth factor receptor signaling pathway
GO:0007189 adenylate cyclase-activating G-protein coupled receptor signaling pathway
GO:0007191 adenylate cyclase-activating dopamine receptor signaling pathway
GO:0007193 adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
GO:0007195 adenylate cyclase-inhibiting dopamine receptor signaling pathway
GO:0007202 activation of phospholipase C activity
GO:0007268 synaptic transmission
GO:0007626 locomotory behavior
GO:0008543 fibroblast growth factor receptor signaling pathway
GO:0009190 cyclic nucleotide biosynthetic process
GO:0034199 activation of protein kinase A activity
GO:0035556 intracellular signal transduction
GO:0044281 small molecule metabolic process
GO:0045087 innate immune response
GO:0048011 neurotrophin TRK receptor signaling pathway
GO:0050885 neuromuscular process controlling balance
GO:0055085 transmembrane transport
GO:0071377 cellular response to glucagon stimulus
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0072372 primary cilium
Mus musculus
Bos taurus
Gene ID
Gene Order
Not yet available
PKA activation pathway
PKA-mediated phosphorylation of CREB pathway
Calmodulin induced events pathway
CaM pathway pathway
DAG and IP3 signaling pathway
DAP12 signaling pathway
DAP12 interactions pathway
Vasopressin regulates renal water homeostasis via Aquaporins pathway
PLC-gamma1 signalling pathway
EGFR interacts with phospholipase C-gamma pathway
Signaling by EGFR pathway
G alpha (i) signalling events pathway
G alpha (s) signalling events pathway
G alpha (z) signalling events pathway
Adenylate cyclase activating pathway pathway
Adenylate cyclase inhibitory pathway pathway
PLC beta mediated events pathway
Opioid Signalling pathway
PLCG1 events in ERBB2 signaling pathway
Signaling by ERBB2 pathway
Phospholipase C-mediated cascade pathway
Signaling by FGFR pathway
Downstream signal transduction pathway
Signaling by PDGF pathway
GABA B receptor activation pathway
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion pathway
Adrenaline,noradrenaline inhibits insulin secretion pathway
Regulation of insulin secretion pathway
PKA activation in glucagon signalling pathway
Glucagon signaling in metabolic regulation pathway
Integration of energy metabolism pathway
Signaling by FGFR in disease pathway
Transmembrane transport of small molecules pathway
Signalling by NGF pathway
Signaling by Hedgehog pathway
Signaling by EGFR in Cancer pathway
Downstream signaling of activated FGFR pathway
Neuronal System pathway
Signaling by GPCR pathway
Innate Immune System pathway
GABA receptor activation pathway
Activation of GABAB receptors pathway
Signal Transduction pathway
GPCR downstream signaling pathway
Hedgehog 'off' state pathway
G-protein mediated events pathway
Immune System pathway
NGF signalling via TRKA from the plasma membrane pathway
Transmission across Chemical Synapses pathway
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell pathway
Metabolism pathway
Inhibition of adenylate cyclase pathway pathway
Ca-dependent events pathway
Aquaporin-mediated transport pathway
Disease pathway
GnRH signaling pathway pathway
Gap junction pathway
Purine metabolism pathway
Melanogenesis pathway
Parkinson's disease pathway
Vascular smooth muscle contraction pathway
Chemokine signaling pathway pathway
Progesterone-mediated oocyte maturation pathway
Dilated cardiomyopathy pathway
Oocyte meiosis pathway
Gastric acid secretion pathway
Pancreatic secretion pathway
Salivary secretion pathway
Bile secretion pathway
GPCR Adenosine A2A receptor signaling pathway pathway
Purine nucleotides nucleosides metabolism pathway
GPCR Dopamine D1like receptor signaling pathway pathway
GPCR signaling pathway
UniProt Splice Variant
Entrez Gene
UniGene Hs.593292 Hs.729601
RefSeq NM_001199642 NM_183357
HPRD 08973
RNA Seq Atlas