Version 5.4
Homo sapiens Gene: PCYT1B
Summary
InnateDB Gene IDBG-53002.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PCYT1B
Gene Name phosphate cytidylyltransferase 1, choline, beta
Synonyms CCTB; CTB
Species Homo sapiens
Ensembl Gene ENSG00000102230
Encoded Proteins
IDBP-53004
phosphate cytidylyltransferase 1, choline, beta
IDBP-53006
phosphate cytidylyltransferase 1, choline, beta
IDBP-53008
phosphate cytidylyltransferase 1, choline, beta
IDBP-594936
phosphate cytidylyltransferase 1, choline, beta
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene belongs to the cytidylyltransferase family. It is involved in the regulation of phosphatidylcholine biosynthesis. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome X:24558087-24672677
Strand Reverse strand
Band p22.11
Transcripts
ENST00000379145 ENSP00000368440
ENST00000379144 ENSP00000368439
ENST00000356768 ENSP00000349211
ENST00000496020 ENSP00000436562
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
Experimentally validated
Total 7 [view]
Protein-Protein 7 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0004105 choline-phosphate cytidylyltransferase activity
Biological Process
GO:0001541 ovarian follicle development
GO:0006644 phospholipid metabolic process
GO:0006656 phosphatidylcholine biosynthetic process
GO:0006657 CDP-choline pathway
GO:0007283 spermatogenesis
GO:0009058 biosynthetic process
GO:0044281 small molecule metabolic process
GO:0046474 glycerophospholipid biosynthetic process
Cellular Component
GO:0005737 cytoplasm
GO:0005789 endoplasmic reticulum membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000035246
View Gene Order
ENSBTAG00000016107
Not yet available
Pathways
NETPATH
REACTOME
REACT_121238
Synthesis of PC pathway
REACT_22258
Metabolism of lipids and lipoproteins pathway
REACT_121401
Glycerophospholipid biosynthesis pathway
REACT_120870
Phospholipid metabolism pathway
REACT_111217
Metabolism pathway
KEGG
hsa00564
Glycerophospholipid metabolism pathway
INOH
PID NCI
Cross-References
SwissProt Q9Y5K3
TrEMBL
UniProt Splice Variant
Entrez Gene 9468
UniGene Hs.660708
RefSeq NM_001163265 NM_001163264 NM_004845
HUGO HGNC:8755
OMIM 604926
CCDS CCDS55391 CCDS14213 CCDS55392
HPRD 05376
IMGT
EMBL AC079168 AF052510 AF148464 AK296333 AK315323 BC045634 CH471074 EU181262
GenPept AAC39754 AAD35088 AAH45634 ABW03924 BAG37725 BAG59022 EAW99021
RNA Seq Atlas 9468

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca