Version 5.4
Homo sapiens Protein: PCYT1B
Summary
InnateDB Protein IDBP-53006.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PCYT1B
Protein Name phosphate cytidylyltransferase 1, choline, beta
Synonyms CCTB; CTB;
Species Homo sapiens
Ensembl Protein ENSP00000368439
InnateDB Gene IDBG-53002 (PCYT1B)
Protein Structure
UniProt Annotation
Function Controls phosphatidylcholine synthesis.
Subcellular Localization Endoplasmic reticulum.
Disease Associations
Tissue Specificity Highly expressed in testis, placenta, brain, ovary and fetus.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
Experimentally validated
Total 7 [view]
Protein-Protein 7 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0004105 choline-phosphate cytidylyltransferase activity
Biological Process
GO:0001541 ovarian follicle development
GO:0006644 phospholipid metabolic process
GO:0006656 phosphatidylcholine biosynthetic process
GO:0006657 CDP-choline pathway
GO:0007283 spermatogenesis
GO:0009058 biosynthetic process
GO:0044281 small molecule metabolic process
GO:0046474 glycerophospholipid biosynthetic process
Cellular Component
GO:0005737 cytoplasm
GO:0005789 endoplasmic reticulum membrane
Protein Structure and Domains
PDB ID
InterPro IPR004821 Cytidyltransferase-like domain
PFAM PF01467
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9Y5K3
PhosphoSite PhosphoSite-Q9Y5K3
TrEMBL
UniProt Splice Variant
Entrez Gene 9468
UniGene Hs.660708
RefSeq NP_004836
HUGO HGNC:8755
OMIM 604926
CCDS CCDS14213
HPRD 05376
IMGT
EMBL AC079168 AF052510 AF148464 AK296333 AK315323 BC045634 CH471074 EU181262
GenPept AAC39754 AAD35088 AAH45634 ABW03924 BAG37725 BAG59022 EAW99021

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca