Version 5.4
Homo sapiens Gene: LAMP1
Summary
InnateDB Gene IDBG-53125.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol LAMP1
Gene Name lysosomal-associated membrane protein 1
Synonyms CD107a; LAMPA; LGP120
Species Homo sapiens
Ensembl Gene ENSG00000185896
Encoded Proteins
IDBP-53127
lysosomal-associated membrane protein 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a member of a family of membrane glycoproteins. This glycoprotein provides selectins with carbohydrate ligands. It may also play a role in tumor cell metastasis. [provided by RefSeq, Jul 2008]
The protein encoded by this gene is a member of a family of membrane glycoproteins. This glycoprotein provides selectins with carbohydrate ligands. It may also play a role in tumor cell metastasis. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 13:113297241-113323672
Strand Forward strand
Band q34
Transcripts
ENST00000332556 ENSP00000333298
ENST00000472564
ENST00000471046
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 26 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated
Total 26 [view]
Protein-Protein 24 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0019899 enzyme binding
GO:0019904 protein domain specific binding
Biological Process
GO:0006914 autophagy
GO:0008626 granzyme-mediated apoptotic signaling pathway
GO:0043323 positive regulation of natural killer cell degranulation
GO:0045954 positive regulation of natural killer cell mediated cytotoxicity
GO:0048102 autophagic cell death
GO:0050821 protein stabilization
GO:0072594 establishment of protein localization to organelle
GO:0090160 Golgi to lysosome transport
GO:1902513 regulation of organelle transport along microtubule
Cellular Component
GO:0005737 cytoplasm
GO:0005764 lysosome
GO:0005765 lysosomal membrane
GO:0005768 endosome
GO:0005770 late endosome
GO:0005771 multivesicular body
GO:0005773 vacuole
GO:0005887 integral component of plasma membrane
GO:0009897 external side of plasma membrane
GO:0009986 cell surface
GO:0010008 endosome membrane
GO:0016020 membrane
GO:0030425 dendrite
GO:0031410 cytoplasmic vesicle
GO:0031982 vesicle
GO:0042383 sarcolemma
GO:0042470 melanosome
GO:0043025 neuronal cell body
GO:0044194 cytolytic granule
GO:0061474 phagolysosome membrane
GO:0070062 extracellular vesicular exosome
GO:0097208 alveolar lamellar body
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000031447
View Gene Order
ENSBTAG00000010242
Not yet available
Pathways
NETPATH
REACTOME
KEGG
hsa04142
Lysosome pathway
hsa04145
Phagosome pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.494419 Hs.707264
RefSeq NM_005561
HUGO
OMIM
CCDS CCDS41909
HPRD 01076
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca