Homo sapiens Gene: PPY
Summary
InnateDB Gene IDBG-53161.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PPY
Gene Name pancreatic polypeptide
Synonyms PNP;
Species Homo sapiens
Ensembl Gene ENSG00000108849
Encoded Proteins
pancreatic polypeptide
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene belongs to the NPY family and it encodes a protein that is synthesized as a 95 aa polypeptide precursor in the pancreatic islets of Langerhans. It is cleaved into two peptide products; the active hormone of 36 aa and an icosapeptide of unknown function. The hormone acts as a regulator of pancreatic and gastrointestinal functions and may be important in the regulation of food intake. Plasma level of this hormone has been shown to be reduced in conditions associated with increased food intake and elevated in anorexia nervosa. In addition, infusion of this hormone in obese rodents has shown to decrease weight gain. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:43940804-43942468
Strand Reverse strand
Band q21.31
Transcripts
ENST00000225992 ENSP00000225992
ENST00000587926
ENST00000591228 ENSP00000466009
ENST00000591703 ENSP00000466546
ENST00000587006 ENSP00000465711
ENST00000587070
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0001664 G-protein coupled receptor binding
GO:0005102 receptor binding
GO:0005179 hormone activity
Biological Process
GO:0007586 digestion
GO:0009306 protein secretion
Cellular Component
GO:0005576 extracellular region
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Class A/1 (Rhodopsin-like receptors) pathway
Signaling by GPCR pathway
Peptide ligand-binding receptors pathway
Signal Transduction pathway
GPCR downstream signaling pathway
G alpha (i) signalling events pathway
GPCR ligand binding pathway
KEGG
INOH
GPCR signaling pathway
PID BIOCARTA
PID NCI
Cross-References
SwissProt P01298
TrEMBL K7EKP2 K7EML0
UniProt Splice Variant
Entrez Gene 5539
UniGene Hs.558368 Hs.743907
RefSeq NM_002722
HUGO HGNC:9327
OMIM 167780
CCDS CCDS11472
HPRD
IMGT
EMBL AC007993 BC032225 BC040033 M11726 M15788 X00491
GenPept AAA60156 AAA60161 AAH32225 AAH40033 CAA25161
RNA Seq Atlas 5539