Homo sapiens Gene: CSF1R
Summary
InnateDB Gene IDBG-53268.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CSF1R
Gene Name colony stimulating factor 1 receptor
Synonyms C-FMS; CD115; CSF-1R; CSFR; FIM2; FMS; HDLS; M-CSF-R;
Species Homo sapiens
Ensembl Gene ENSG00000182578
Encoded Proteins
colony stimulating factor 1 receptor
colony stimulating factor 1 receptor
colony stimulating factor 1 receptor
colony stimulating factor 1 receptor
colony stimulating factor 1 receptor
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation from Orthologs
Summary
[Mus musculus] Prostaglandin E2 transactivates Csf1r and synergizes with its signalling at Mapk1/Mapk3 level in promoting macrophage migration.
Entrez Gene
Summary The protein encoded by this gene is the receptor for colony stimulating factor 1, a cytokine which controls the production, differentiation, and function of macrophages. This receptor mediates most if not all of the biological effects of this cytokine. Ligand binding activates the receptor kinase through a process of oligomerization and transphosphorylation. The encoded protein is a tyrosine kinase transmembrane receptor and member of the CSF1/PDGF receptor family of tyrosine-protein kinases. Mutations in this gene have been associated with a predisposition to myeloid malignancy. The first intron of this gene contains a transcriptionally inactive ribosomal protein L7 processed pseudogene oriented in the opposite direction. [provided by RefSeq, Jul 2008]
The protein encoded by this gene is the receptor for colony stimulating factor 1, a cytokine which controls the production, differentiation, and function of macrophages. This receptor mediates most if not all of the biological effects of this cytokine. Ligand binding activates the receptor kinase through a process of oligomerization and transphosphorylation. The encoded protein is a tyrosine kinase transmembrane receptor and member of the CSF1/PDGF receptor family of tyrosine-protein kinases. Mutations in this gene have been associated with a predisposition to myeloid malignancy. The first intron of this gene contains a transcriptionally inactive ribosomal protein L7 processed pseudogene oriented in the opposite direction. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:150053291-150113372
Strand Reverse strand
Band q32
Transcripts
ENST00000286301 ENSP00000286301
ENST00000504875 ENSP00000422212
ENST00000509861
ENST00000515068 ENSP00000427545
ENST00000515239
ENST00000513609
ENST00000502660
ENST00000511344 ENSP00000421174
ENST00000543093 ENSP00000445282
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 44 experimentally validated interaction(s) in this database.
They are also associated with 19 interaction(s) predicted by orthology.
Experimentally validated
Total 44 [view]
Protein-Protein 35 [view]
Protein-DNA 9 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 19 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0005011 macrophage colony-stimulating factor receptor activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0019903 protein phosphatase binding
GO:0019955 cytokine binding
GO:0042803 protein homodimerization activity
Biological Process
GO:0001934 positive regulation of protein phosphorylation
GO:0006468 protein phosphorylation
GO:0006954 inflammatory response
GO:0007165 signal transduction
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
GO:0007275 multicellular organismal development
GO:0008283 cell proliferation
GO:0008284 positive regulation of cell proliferation
GO:0008360 regulation of cell shape
GO:0018108 peptidyl-tyrosine phosphorylation
GO:0019221 cytokine-mediated signaling pathway
GO:0030097 hemopoiesis
GO:0030224 monocyte differentiation
GO:0030225 macrophage differentiation
GO:0030316 osteoclast differentiation
GO:0030335 positive regulation of cell migration
GO:0031529 ruffle organization
GO:0036006 cellular response to macrophage colony-stimulating factor stimulus
GO:0038145 macrophage colony-stimulating factor signaling pathway
GO:0042517 positive regulation of tyrosine phosphorylation of Stat3 protein
GO:0045087 innate immune response
GO:0045124 regulation of bone resorption
GO:0045217 cell-cell junction maintenance
GO:0046488 phosphatidylinositol metabolic process
GO:0046777 protein autophosphorylation
GO:0048015 phosphatidylinositol-mediated signaling
GO:0060603 mammary gland duct morphogenesis
GO:0061098 positive regulation of protein tyrosine kinase activity
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0071345 cellular response to cytokine stimulus
GO:0071902 positive regulation of protein serine/threonine kinase activity
GO:0090197 positive regulation of chemokine secretion
GO:2000147 positive regulation of cell motility
GO:2000249 regulation of actin cytoskeleton reorganization
Cellular Component
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0009986 cell surface
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0043235 receptor complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
KEGG
Cytokine-cytokine receptor interaction pathway
Endocytosis pathway
Osteoclast differentiation pathway
Hematopoietic cell lineage pathway
Pathways in cancer pathway
INOH
PID BIOCARTA
Mets affect on macrophage differentiation [Biocarta view]
PID NCI
Integrins in angiogenesis
Signaling events mediated by PTP1B
C-MYB transcription factor network
Signaling events mediated by TCPTP
Cross-References
SwissProt
TrEMBL D6RGW1
UniProt Splice Variant
Entrez Gene 1436
UniGene Hs.586219
RefSeq NM_001288705 NM_005211
HUGO HGNC:2433
OMIM 164770
CCDS CCDS4302
HPRD 01269
IMGT
EMBL AC011382
GenPept
RNA Seq Atlas 1436