InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: CSF1R

Summary

InnateDB Gene

IDBG-646265.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CSF1R

Gene Name

macrophage colony-stimulating factor 1 receptor precursor

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000012771

Encoded Proteins

IDBP-699053

macrophage colony-stimulating factor 1 receptor

IDBP-699057

macrophage colony-stimulating factor 1 receptor

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation from Orthologs

Summary

PMID 25757564

[Mus musculus] Prostaglandin E2 transactivates Csf1r and synergizes with its signalling at Mapk1/Mapk3 level in promoting macrophage migration.

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000182578:
The protein encoded by this gene is the receptor for colony stimulating factor 1, a cytokine which controls the production, differentiation, and function of macrophages. This receptor mediates most if not all of the biological effects of this cytokine. Ligand binding activates the receptor kinase through a process of oligomerization and transphosphorylation. The encoded protein is a tyrosine kinase transmembrane receptor and member of the CSF1/PDGF receptor family of tyrosine-protein kinases. Mutations in this gene have been associated with a predisposition to myeloid malignancy. The first intron of this gene contains a transcriptionally inactive ribosomal protein L7 processed pseudogene oriented in the opposite direction. [provided by RefSeq, Jul 2008]
The protein encoded by this gene is the receptor for colony stimulating factor 1, a cytokine which controls the production, differentiation, and function of macrophages. This receptor mediates most if not all of the biological effects of this cytokine. Ligand binding activates the receptor kinase through a process of oligomerization and transphosphorylation. The encoded protein is a tyrosine kinase transmembrane receptor and member of the CSF1/PDGF receptor family of tyrosine-protein kinases. Mutations in this gene have been associated with a predisposition to myeloid malignancy. The first intron of this gene contains a transcriptionally inactive ribosomal protein L7 processed pseudogene oriented in the opposite direction. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 7:63379475-63410973

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000042906	ENSBTAP00000040510
ENSBTAT00000016977	ENSBTAP00000016977

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 33 interaction(s) predicted by orthology.

Predicted by orthology
Total	33 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0004672	protein kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0004714	transmembrane receptor protein tyrosine kinase activity
GO:0005011	macrophage colony-stimulating factor receptor activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016301	kinase activity
GO:0016740	transferase activity
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0019903	protein phosphatase binding
GO:0019955	cytokine binding
GO:0042803	protein homodimerization activity

Biological Process

GO:0001934	positive regulation of protein phosphorylation
GO:0006468	protein phosphorylation
GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway
GO:0008283	cell proliferation
GO:0008284	positive regulation of cell proliferation
GO:0008360	regulation of cell shape
GO:0016310	phosphorylation
GO:0018108	peptidyl-tyrosine phosphorylation
GO:0019221	cytokine-mediated signaling pathway
GO:0030097	hemopoiesis
GO:0030316	osteoclast differentiation
GO:0030335	positive regulation of cell migration
GO:0031529	ruffle organization
GO:0036006	cellular response to macrophage colony-stimulating factor stimulus
GO:0038145	macrophage colony-stimulating factor signaling pathway
GO:0042517	positive regulation of tyrosine phosphorylation of Stat3 protein
GO:0045217	cell-cell junction maintenance
GO:0046488	phosphatidylinositol metabolic process
GO:0046777	protein autophosphorylation
GO:0048015	phosphatidylinositol-mediated signaling
GO:0061098	positive regulation of protein tyrosine kinase activity
GO:0070374	positive regulation of ERK1 and ERK2 cascade
GO:0071345	cellular response to cytokine stimulus
GO:0071902	positive regulation of protein serine/threonine kinase activity
GO:0090197	positive regulation of chemokine secretion
GO:2000147	positive regulation of cell motility
GO:2000249	regulation of actin cytoskeleton reorganization